ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells

Bergaggio, E; Tai, WT; Aroldi, A; Mecca, C; Landoni, E; Nüesch, M; Mota, I; Metovic, J; Molinaro, L; Ma, LY; Alvarado, D; Ambrogio, C; Voena, C; Blasco, RB; Li, TQ; Klein, D; Irvine, DJ; Papotti, M; Savoldo, B; Dotti, G; Chiarle, R

Chiarle, R (通讯作者)，Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA.;Chiarle, R (通讯作者)，Harvard Med Sch, Boston, MA 02115 USA.;Chiarle, R (通讯作者)，Univ Torino, Dept Mol Biotechnol & Hlth Sci, I-10126 Turin, Italy.

CANCER CELL, 2023; 41 (12):

Abstract

Selection of the best tumor antigen is critical for the therapeutic success of chimeric antigen receptor (CAR) T cells in hematologic malignancies and......

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