Desymmetrization of pibrentasvir for efficient prodrug synthesis

Voight, EA; Greszler, SN; Hartung, J; Ji, JG; Klix, RC; Randolph, JT; Shelat, BH; Waters, JE; DeGoey, DA

Voight, EA (corresponding author), Drug Discovery Sci & Technol, 1 North Waukegan Rd, N Chicago, IL 60064 USA.

CHEMICAL SCIENCE, 2021; 12 (29): 10076

Abstract

A novel and practical desymmetrization tactic is described to access a new class of pibrentasvir prodrugs. The homotopic benzimidazoles of pibrentasvi......

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