Copper-Catalyzed Lactamization of (E)-2-(2-Bromophenyl)-3-arylacrylamides for the Synthesis of (E)-3-Arylideneindolin-2-ones

Luo, X; Zhang, QZ; Jiang, Y; Wang, CX; Song, XH; Li, JH; Yan, QF; Chan, ASC; Zou, Y

Zou, Y (corresponding author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China.; Zou, Y (corresponding author), Guangdong Prov Key Lab Chiral Mol & Drug Discover, Guangzhou 510000, Peoples R China.

JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (9): 6698

Abstract

A copper-catalyzed, ligand-free intramolecular C-N coupling of (E)-2-(2-bromophenyl)-3-arylacrylamides has been developed. This protocol provides an e......

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