Eur Heart J:预防心血管病,应从口腔健康开始

2019-04-12 xujing 中国循环杂志

近期,《欧洲心脏杂志》一项韩国近25万人的前瞻性研究证实,牙周病、龋齿较多或掉牙更多的人,心血管事件风险更高。而且,口腔炎症性疾病增加心血管事件风险影响,超过了传统心血管危险因素的作用。该研究还发现,更好的口腔健康行为有预防心血管病作用:每天多刷一次牙则使心血管事件风险降低9%,每年洗牙一次以上则使风险降低 14%。

近期,《欧洲心脏杂志》一项韩国近25万人的前瞻性研究证实,牙周病、龋齿较多或掉牙更多的人,血管事件风险更高。而且,口腔炎症性疾病增加血管事件风险影响,超过了传统心血管危险因素的作用。该研究还发现,更好的口腔健康行为有预防心血管病作用:每天多刷一次牙则使心血管事件风险降低9%,每年洗牙一次以上则使风险降低 14%。

《欧洲心脏杂志》同期刊发的述评则称,预防心血管病,应从口腔健康开始。述评称,已有证据显示,炎症在动脉粥样硬化中起着重要作用。

以慢性炎症为特征的疾病,包括类风湿性关节炎、银屑病、口腔炎症性疾病、慢性肠道疾病等,与心血管事件的风险增加有关。其中,口腔炎性疾病与心血管疾病风险之间的关系备受关注。作者认为,口腔疾病在普通人群中非常普遍,全球39亿人都有一定程度的口腔疾病,其患病率明显高于其他常见的心血管危险因素,如糖尿病。如果可以证明口腔炎症与动脉粥样硬化的因果关系,那么在普通人群中,可能从改善的口腔健康中获得心血管方面的益处是巨大的,同时大大降低医疗成本。

之前有研究证明,治疗牙周炎和牙龈疾病可降低全身的炎症水平,并改善内皮细胞功能。也有研究证实,治疗牙周炎和牙龈疾病改善了代谢,并防止了2型糖尿病患者的肾功能恶化。述评指出,口腔炎症患者的全身炎症负荷是升高的,口腔疾病与心血管疾病的关系可能还在于全身氧化应激的增加。

原始出处:

Masi S1,, D'Aiuto F, Deanfield J.Cardiovascular prevention starts from your mouth.Eur Heart J. 2019 Apr 7;40(14):1146-1148.

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    2019-04-14 zhaojie88
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    2019-04-14 slcumt

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