BMJ Open:肥胖与慢性鼻窦炎伴鼻息肉的关系

2021-06-20 AlexYang MedSci原创

肥胖是一个迅速增长的全球健康问题。全球有超过19亿人归类为超重,超过6.5亿人归类为肥胖。与肥胖有关的疾病包括哮喘、心血管疾病和糖尿病。由于慢性炎症,某些类型的癌症也与肥胖症有关。有报告表明,肥胖有可

肥胖是一个迅速增长的全球健康问题。全球有超过19亿人归类为超重,超过6.5亿人归类为肥胖。与肥胖有关的疾病包括哮喘、血管疾病和糖尿病。由于慢性炎症,某些类型的癌症也与肥胖症有关。有报告表明,肥胖有可能导致慢性炎症性疾病。然而,关于肥胖对鼻窦炎症性疾病的影响仍有争议。

近期,有研究人员对全国范围内的韩国国民健康和营养调查数据进行了横断面分析,评估肥胖与有鼻息肉的慢性鼻窦炎(CRSwNP)或无鼻息肉的慢性鼻窦炎(CRSsNP)之间的关系

研究的设计是健康调查数据的回顾性横断面分析。总共有32384名参与者,年龄在19岁及以上,他们均具有CRS和肥胖症的数据。CRSwNP或CRSsNP的诊断由训练有素的耳鼻喉科医生通过鼻窦内窥镜检查和病史调查进行。分别用身体质量指数(BMI)和腰围(WC)诊断全身性肥胖和中心性肥胖。

研究人员根据BMI和WC,采用多变量逻辑回归分析来阐明CRSwNP或CRSsNP与肥胖的关系,并招募了非肥胖者作为对照。结果发现,CRSwNP的患病率在全身性(OR,1.438;95% CI,1.170至1.768;P<0.001)和中心性(OR,1.251;95% CI,1.031至1.520;P=0.033)肥胖组均比对照组高。CRSsNP的患病率与肥胖没有关系。在逻辑回归分析中,嗅觉功能障碍(OR,1.329;95% CI,1.137至1.553;p<0.001)和脓性分泌物(OR,1.383;95% CI,1.193至1.603;p<0.001)在中心性肥胖组的发病率高于对照组。

CRSwNP和CRSsNP在肥胖人群中的患病率

综上所述,他们证明了CRSwNP与全身性肥胖和中心性肥胖之间存在关联。为了更好地了解CRSwNP的发病机理,有必要进一步调查这种关联的机制

原始出处:

Jae-Sung Nam, Yun Ho Roh, Wasan Almazouq Fahad et al. Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study. BMJ Open. May 2021

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    2022-05-24 feather89
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    2022-03-05 gaoxiaoe
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