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BMJ：警惕抗抑郁症药物导致患者体重增加风险

2018-05-28 zhangfan MedSci原创

抗抑郁药物体重增加肥胖
关注

研究认为，抗抑郁药的广泛使用可能导致患者体重增加，在临床应用过程中应适当予以关注

近日研究人员考察了抗抑郁药处方与体重增加的长期相关性

136762名男性以及157957名女性参与研究，接受3次及以上体重指数测量。研究的主要终点为抑郁症治疗处方、体重增加5%事件、超重及肥胖。采用泊松模型评估抑郁症处方与体重增加之间的关系，并调整年龄、性别、抑郁病情、共病、抗癫痫药物或抗精神病药物的重复使用、戒断、吸烟和饮食等因素。

参与研究的人群中，男性17803人 (13.0%)以及女性35307 (22.4%)接受抗抑郁药物治疗，患者平均年龄51.5岁。随访1836452个患者年，非抑郁症治疗人群每100患者年中，体重增加5%以上事件发生8.1起，抑郁患者为11.2起（rr=1.21， 95% CI 1.19-1.22， P<0.001)，研究开始后第2年，抗抑郁治疗人群的体重增加事件增加为每100患者年27例。基线体重正常人群，抗抑郁治疗导致超重或肥胖的比值比为1.29；对于基线超重人群，抗抑郁治疗导致肥胖的比值比为1.29。

研究认为，抗抑郁药的广泛使用可能导致患者体重增加，在临床应用过程中应适当予以关注。

原始出处：


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    2019-03-22 gaoxiaoe

    #BMJ#

    0

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    2018-06-09 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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    2018-06-04 yfjms

    学习

    0

  4. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon May 28 11:02:40 CST 2018, time=2018-05-28, status=1, ipAttribution=)]
    2018-06-01 溜溜梅不酸

    学习了谢谢分享

    0

  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon May 28 11:02:40 CST 2018, time=2018-05-28, status=1, ipAttribution=)]
    2018-05-30 839640778

    #体重增加#

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon May 28 11:02:40 CST 2018, time=2018-05-28, status=1, ipAttribution=)]
    2018-05-30 wushaoling

    #抗抑郁#

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon May 28 11:02:40 CST 2018, time=2018-05-28, status=1, ipAttribution=)]
    2018-05-29 baihao215

    具体药物应该罗列出来的

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon May 28 11:02:40 CST 2018, time=2018-05-28, status=1, ipAttribution=)]
    2018-05-28 惠映实验室

    学习了.谢谢分享.

    0

  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon May 28 11:02:40 CST 2018, time=2018-05-28, status=1, ipAttribution=)]
    2018-05-28 清风拂面

    谢谢分享学习

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon May 28 11:02:40 CST 2018, time=2018-05-28, status=1, ipAttribution=)]
    2018-05-28 明月清辉

    谢谢分享.学习了

    0

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    对于妊娠期药物的使用是有争议的，某些抗抑郁药在怀孕早期使用和出生缺陷的之间可能存在的相关性发表在BMJ杂志上。作者报告了一些没有联系的药物，他们测试了，但使用特定的选择性血清素再摄取抑制剂（SSRIs）时会增加风险。    Patrick O’Brien博士，英国皇家妇产科学院发言人（RCOG）说：    “这项研究探讨了在怀孕的

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根据哥伦比亚大学医学中心的哥伦比亚大学梅尔曼学院公共卫生学院和纽约州立精神病研究所的研究员介绍，通常用抗忧郁药治疗产妇精神障碍后可引发风险较低的某些妊娠并发症，包括早产和通过剖腹产分娩。然而，这些药物 ——选择性血清素再吸收抑制剂（SSRIs）—— 可导致新生儿问题的风险增加。研究结果在线发表在美国精神病学杂志上。“据我们所知，在怀孕期间服用抗抑郁药风险较低的早产之间的关联是一个新的发现，”艾伦·

Am J Med：抗抑郁药物与因低钠血症住院是否相关？

2018年1月，发表在《Am J Med》的一项研究由瑞典科学家进行的病例对照研究，考察了选择性5-羟色胺再摄取抑制剂（SSRIs）和其他抗抑郁药物与因低钠血症住院之间的相关性。

JAMA Pediatrics：孕期服用抗抑郁药易导致儿童自闭症

导致民众患自闭症谱系障碍(ASD)的风险因素十分复杂的，且十分庞大。这研究探究加拿大女性孕期服用抗抑郁药物对儿童患自闭症谱系障碍的影响。怀孕期间使用抗抑郁药对孕妇和孩子的影响仍然争论补休。医生也不清楚是否应该为孕妇开具抗抑郁药。若开具抗抑郁药物，可能胎儿有不利影响，如果不开具则对母亲有不利影响。在美国，有1/10的孕妇服用抗抑郁药物。面对孕妇普遍使用抗抑郁药物，研究人员认为他们有必要进行深入了解。

BMJ：服用抗抑郁药物增加儿童自杀和攻击风险

目的该研究的目的是探究选择性5 -羟色胺和5 -羟色胺-去甲肾上腺素再摄取抑制剂对民众的危害。 设计该研究为系统综述和荟萃分析。 主要结果研究人员关注的主要结果为服药民众的死亡率和自杀倾向。次要结果为民众的暴力倾向和和失静症的发生率。 数据来源数据来源于欧洲和英国的药品监管机构对度洛西汀、氟西汀、帕罗西汀、舍曲林、文拉法辛的一些临床研究报告和总结试验及相关药品网站的相关信息。所选取的研究必须为选择

JAMA：妊娠后期使用抗抑郁药物轻度增加新生儿持续肺动脉高压的风险（Medicaid研究）

    重要性  妊娠期间选择5-羟色胺再摄取抑制剂（SSRI）抗抑郁药与新生儿持续性肺动脉高血压（PPHN）之间的联系，自从2006年美国食品与药品管理局发布公共健康咨询开始就存在争议了。    意义  考察妊娠后期暴露于不同的抗抑郁药物后PPHN的风险。    设计  队列研究嵌套在2000-2010年美