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Front Immunol:免疫复合物介导的膜性增生性肾小球肾炎和C3肾小球疾病患者血清FHR-5水平及CFHR5基因变异

2022-01-14 从医路漫漫 MedSci原创

膜性增生性肾小球肾炎和C3肾小球
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因子H相关蛋白5(FHR-5)是补体因子H蛋白家族的成员。由于与替代途径的主要补体调节因子H的同源性，它也可能与肾脏疾病的发病机制有关，在肾脏疾病中，因子H和替代途径失调起作用。

背景：因子H相关蛋白5(FHR-5)是补体因子H蛋白家族的成员。由于与替代途径的主要补体调节因子H的同源性，它也可能与肾脏疾病的发病机制有关，在肾脏疾病中，因子H和替代途径失调起作用。在此，我们首次报道了免疫复合物介导的膜增生性肾炎(IC-MPGN)和补体C3肾小球病变(C3G)患者CFHR5和血清FHR-5水平的变化以及临床、遗传学、补体和随访资料。

方法：共120例经组织学证实为IC-MPGN/C3G的患者纳入研究。ELISA法检测血清FHR-5水平，Sanger测序分析CFHR5基因，筛选出的突变体作为重组蛋白进行ELISA和表面等离子共振(SPR)研究。采用自制ELISA法检测FHR-5血清水平。用1mg /ml的市售单克隆小鼠抗人FHR-5 (IgG1，克隆#390513,R&D Systems，明尼阿波利斯，明尼苏达州，美国)包被磷酸盐缓冲盐水(PBS)过夜，次日用PBS和2%的牛血清白蛋白(BSA)阻断。血清在含1% BSA和0.05% Tween-20的PBS中按1:100稀释，加入平板中[1 h，室温(RT)]。采用山羊抗人FHR-5 IgG (Cat。编号:AF3845，研发系统，明尼阿波利斯，明尼苏达州，美国)。样品浓度根据2倍稀释系列重组人FHR-5蛋白(R&D Systems，明尼阿波利斯，明尼苏达州，美国)的标准曲线确定。试验间和试验内的差异分别为11.8%和7.8%。经Western blot (WB)检测，FHR-5 ELISA的特异性得到证实，单克隆抗FHR-5作为捕获抗体，未检测到FHR-5以外的FHR。

结果：14例患者(12.6%)观察到8个CFHR5外显子变异。患者血清FHR-5水平低于对照组。初诊时血清FHR-5浓度较低与随访期间肾脏存活率较好有关；此外，它与补体过度激活的迹象和有临床意义的簇有明显的相关性。

表1 有无CFHR5变异的患者的临床特征。

表2在14例C3G/IC-MPGN患者中发现CFHR5基因变异。

图1 C3肾小球病(C3G)/免疫复合物介导的膜增生性肾小球肾炎(IC-MPGN)患者和健康人群中因子H相关蛋白5 (FHR-5)的水平。用Kruskal-Wallis检验确定1p值。*p < 0.05。

图2 错义和移码CFHR5变异的定位及血清H因子相关蛋白5(FHR-5)水平。

结论：FHR-5蛋白可能在IC-MPGN/C3G的发病机制中起微调作用。

原文出处：Garam N,  Cserhalmi M,  Prohászka Z,et al.CFHR5FHR-5 Serum Levels and  Genetic Variations in Patients With Immune Complex-Mediated Membranoproliferative Glomerulonephritis and C3-Glomerulopathy.Front Immunol 2021;12

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    2022-03-24 yang0210

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    #疾病患者#

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    2022-08-31 meichuangyi

    #肾小球疾病#

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  4. 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createdName=hmwwww, createdTime=Thu Dec 29 02:43:55 CST 2022, time=2022-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694148, encodeId=5dbd1694148f3, content=<a href='/topic/show?id=595d8253132' target=_blank style='color:#2F92EE;'>#肾小球疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82531, encryptionId=595d8253132, topicName=肾小球疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=610229571547, createdName=meichuangyi, createdTime=Wed Aug 31 20:43:55 CST 2022, time=2022-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757340, encodeId=68241e57340da, content=<a href='/topic/show?id=2f354231613' target=_blank style='color:#2F92EE;'>#增生性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42316, encryptionId=2f354231613, topicName=增生性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f7c37300907, createdName=ms7514935887898259, createdTime=Tue Jul 19 18:43:55 CST 2022, time=2022-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314203, encodeId=fd1a1314203ec, content=<a href='/topic/show?id=b5e641e1279' target=_blank style='color:#2F92EE;'>#基因变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41712, encryptionId=b5e641e1279, topicName=基因变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512d422, createdName=canlab, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342949, encodeId=17831342949d4, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522260, encodeId=4c4c152226069, content=<a href='/topic/show?id=83732900161' target=_blank style='color:#2F92EE;'>#免疫复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29001, encryptionId=83732900161, topicName=免疫复合物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=311711435936, createdName=zhaohui6735, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532314, encodeId=5acc15323141b, content=<a href='/topic/show?id=10b5825e4aa' target=_blank style='color:#2F92EE;'>#肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82574, encryptionId=10b5825e4aa, topicName=肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84df12331144, createdName=villahu, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537631, encodeId=636e153e63111, content=<a href='/topic/show?id=19c182535f1' target=_blank style='color:#2F92EE;'>#肾小球肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82535, encryptionId=19c182535f1, topicName=肾小球肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=132d12890104, createdName=qindq, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=)]
    2022-07-19 ms7514935887898259

    #增生性#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1910668, encodeId=ce8c191066823, content=<a href='/topic/show?id=b45b426195e' target=_blank style='color:#2F92EE;'>#复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42619, encryptionId=b45b426195e, topicName=复合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Thu Mar 24 04:43:55 CST 2022, time=2022-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799199, encodeId=d7711e99199bc, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Thu Dec 29 02:43:55 CST 2022, time=2022-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694148, encodeId=5dbd1694148f3, content=<a href='/topic/show?id=595d8253132' target=_blank style='color:#2F92EE;'>#肾小球疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82531, encryptionId=595d8253132, topicName=肾小球疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=610229571547, createdName=meichuangyi, createdTime=Wed Aug 31 20:43:55 CST 2022, time=2022-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757340, encodeId=68241e57340da, content=<a href='/topic/show?id=2f354231613' target=_blank style='color:#2F92EE;'>#增生性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42316, encryptionId=2f354231613, topicName=增生性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f7c37300907, createdName=ms7514935887898259, createdTime=Tue Jul 19 18:43:55 CST 2022, time=2022-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314203, encodeId=fd1a1314203ec, content=<a href='/topic/show?id=b5e641e1279' target=_blank style='color:#2F92EE;'>#基因变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41712, encryptionId=b5e641e1279, topicName=基因变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512d422, createdName=canlab, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342949, encodeId=17831342949d4, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522260, encodeId=4c4c152226069, content=<a href='/topic/show?id=83732900161' target=_blank style='color:#2F92EE;'>#免疫复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29001, encryptionId=83732900161, topicName=免疫复合物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=311711435936, createdName=zhaohui6735, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532314, encodeId=5acc15323141b, content=<a href='/topic/show?id=10b5825e4aa' target=_blank style='color:#2F92EE;'>#肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82574, encryptionId=10b5825e4aa, topicName=肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84df12331144, createdName=villahu, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537631, encodeId=636e153e63111, content=<a href='/topic/show?id=19c182535f1' target=_blank style='color:#2F92EE;'>#肾小球肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82535, encryptionId=19c182535f1, topicName=肾小球肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=132d12890104, createdName=qindq, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=)]
    2022-01-16 canlab

    #基因变异#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1910668, encodeId=ce8c191066823, content=<a href='/topic/show?id=b45b426195e' target=_blank style='color:#2F92EE;'>#复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42619, encryptionId=b45b426195e, topicName=复合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Thu Mar 24 04:43:55 CST 2022, time=2022-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799199, encodeId=d7711e99199bc, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Thu Dec 29 02:43:55 CST 2022, time=2022-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694148, encodeId=5dbd1694148f3, content=<a href='/topic/show?id=595d8253132' target=_blank style='color:#2F92EE;'>#肾小球疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82531, encryptionId=595d8253132, topicName=肾小球疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=610229571547, createdName=meichuangyi, createdTime=Wed Aug 31 20:43:55 CST 2022, time=2022-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757340, encodeId=68241e57340da, content=<a href='/topic/show?id=2f354231613' target=_blank style='color:#2F92EE;'>#增生性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42316, encryptionId=2f354231613, topicName=增生性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f7c37300907, createdName=ms7514935887898259, createdTime=Tue Jul 19 18:43:55 CST 2022, time=2022-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314203, encodeId=fd1a1314203ec, content=<a href='/topic/show?id=b5e641e1279' target=_blank style='color:#2F92EE;'>#基因变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41712, encryptionId=b5e641e1279, topicName=基因变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512d422, createdName=canlab, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342949, encodeId=17831342949d4, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522260, encodeId=4c4c152226069, content=<a href='/topic/show?id=83732900161' target=_blank style='color:#2F92EE;'>#免疫复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29001, encryptionId=83732900161, topicName=免疫复合物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=311711435936, createdName=zhaohui6735, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532314, encodeId=5acc15323141b, content=<a href='/topic/show?id=10b5825e4aa' target=_blank style='color:#2F92EE;'>#肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82574, encryptionId=10b5825e4aa, topicName=肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84df12331144, createdName=villahu, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537631, encodeId=636e153e63111, content=<a href='/topic/show?id=19c182535f1' target=_blank style='color:#2F92EE;'>#肾小球肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82535, encryptionId=19c182535f1, topicName=肾小球肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=132d12890104, createdName=qindq, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=)]
    2022-01-16 12498dabm77暂无昵称

    #变异#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1910668, encodeId=ce8c191066823, content=<a href='/topic/show?id=b45b426195e' target=_blank style='color:#2F92EE;'>#复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42619, encryptionId=b45b426195e, topicName=复合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Thu Mar 24 04:43:55 CST 2022, time=2022-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799199, encodeId=d7711e99199bc, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Thu Dec 29 02:43:55 CST 2022, time=2022-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694148, encodeId=5dbd1694148f3, content=<a href='/topic/show?id=595d8253132' target=_blank style='color:#2F92EE;'>#肾小球疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82531, encryptionId=595d8253132, topicName=肾小球疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=610229571547, createdName=meichuangyi, createdTime=Wed Aug 31 20:43:55 CST 2022, time=2022-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757340, encodeId=68241e57340da, content=<a href='/topic/show?id=2f354231613' target=_blank style='color:#2F92EE;'>#增生性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42316, encryptionId=2f354231613, topicName=增生性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f7c37300907, createdName=ms7514935887898259, createdTime=Tue Jul 19 18:43:55 CST 2022, time=2022-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314203, encodeId=fd1a1314203ec, content=<a href='/topic/show?id=b5e641e1279' target=_blank style='color:#2F92EE;'>#基因变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41712, encryptionId=b5e641e1279, topicName=基因变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512d422, createdName=canlab, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342949, encodeId=17831342949d4, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522260, encodeId=4c4c152226069, content=<a href='/topic/show?id=83732900161' target=_blank style='color:#2F92EE;'>#免疫复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29001, encryptionId=83732900161, topicName=免疫复合物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=311711435936, createdName=zhaohui6735, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532314, encodeId=5acc15323141b, content=<a href='/topic/show?id=10b5825e4aa' target=_blank style='color:#2F92EE;'>#肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82574, encryptionId=10b5825e4aa, topicName=肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84df12331144, createdName=villahu, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537631, encodeId=636e153e63111, content=<a href='/topic/show?id=19c182535f1' target=_blank style='color:#2F92EE;'>#肾小球肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82535, encryptionId=19c182535f1, topicName=肾小球肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=132d12890104, createdName=qindq, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=)]
    2022-01-16 zhaohui6735

    #免疫复合物#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1910668, encodeId=ce8c191066823, content=<a href='/topic/show?id=b45b426195e' target=_blank style='color:#2F92EE;'>#复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42619, encryptionId=b45b426195e, topicName=复合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Thu Mar 24 04:43:55 CST 2022, time=2022-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799199, encodeId=d7711e99199bc, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Thu Dec 29 02:43:55 CST 2022, time=2022-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694148, encodeId=5dbd1694148f3, content=<a href='/topic/show?id=595d8253132' target=_blank style='color:#2F92EE;'>#肾小球疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82531, encryptionId=595d8253132, topicName=肾小球疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=610229571547, createdName=meichuangyi, createdTime=Wed Aug 31 20:43:55 CST 2022, time=2022-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757340, encodeId=68241e57340da, content=<a href='/topic/show?id=2f354231613' target=_blank style='color:#2F92EE;'>#增生性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42316, encryptionId=2f354231613, topicName=增生性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f7c37300907, createdName=ms7514935887898259, createdTime=Tue Jul 19 18:43:55 CST 2022, time=2022-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314203, encodeId=fd1a1314203ec, content=<a href='/topic/show?id=b5e641e1279' target=_blank style='color:#2F92EE;'>#基因变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41712, encryptionId=b5e641e1279, topicName=基因变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512d422, createdName=canlab, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342949, encodeId=17831342949d4, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522260, encodeId=4c4c152226069, content=<a href='/topic/show?id=83732900161' target=_blank style='color:#2F92EE;'>#免疫复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29001, encryptionId=83732900161, topicName=免疫复合物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=311711435936, createdName=zhaohui6735, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532314, encodeId=5acc15323141b, content=<a href='/topic/show?id=10b5825e4aa' target=_blank style='color:#2F92EE;'>#肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82574, encryptionId=10b5825e4aa, topicName=肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84df12331144, createdName=villahu, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537631, encodeId=636e153e63111, content=<a href='/topic/show?id=19c182535f1' target=_blank style='color:#2F92EE;'>#肾小球肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82535, encryptionId=19c182535f1, topicName=肾小球肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=132d12890104, createdName=qindq, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=)]
    2022-01-16 villahu

    #肾炎#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1910668, encodeId=ce8c191066823, content=<a href='/topic/show?id=b45b426195e' target=_blank style='color:#2F92EE;'>#复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42619, encryptionId=b45b426195e, topicName=复合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Thu Mar 24 04:43:55 CST 2022, time=2022-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799199, encodeId=d7711e99199bc, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Thu Dec 29 02:43:55 CST 2022, time=2022-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694148, encodeId=5dbd1694148f3, content=<a href='/topic/show?id=595d8253132' target=_blank style='color:#2F92EE;'>#肾小球疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82531, encryptionId=595d8253132, topicName=肾小球疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=610229571547, createdName=meichuangyi, createdTime=Wed Aug 31 20:43:55 CST 2022, time=2022-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757340, encodeId=68241e57340da, content=<a href='/topic/show?id=2f354231613' target=_blank style='color:#2F92EE;'>#增生性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42316, encryptionId=2f354231613, topicName=增生性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f7c37300907, createdName=ms7514935887898259, createdTime=Tue Jul 19 18:43:55 CST 2022, time=2022-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314203, encodeId=fd1a1314203ec, content=<a href='/topic/show?id=b5e641e1279' target=_blank style='color:#2F92EE;'>#基因变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41712, encryptionId=b5e641e1279, topicName=基因变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512d422, createdName=canlab, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342949, encodeId=17831342949d4, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522260, encodeId=4c4c152226069, content=<a href='/topic/show?id=83732900161' target=_blank style='color:#2F92EE;'>#免疫复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29001, encryptionId=83732900161, topicName=免疫复合物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=311711435936, createdName=zhaohui6735, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532314, encodeId=5acc15323141b, content=<a href='/topic/show?id=10b5825e4aa' target=_blank style='color:#2F92EE;'>#肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82574, encryptionId=10b5825e4aa, topicName=肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84df12331144, createdName=villahu, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537631, encodeId=636e153e63111, content=<a href='/topic/show?id=19c182535f1' target=_blank style='color:#2F92EE;'>#肾小球肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82535, encryptionId=19c182535f1, topicName=肾小球肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=132d12890104, createdName=qindq, createdTime=Sun Jan 16 13:43:55 CST 2022, time=2022-01-16, status=1, ipAttribution=)]
    2022-01-16 qindq

    #肾小球肾炎#

    0