Neurology:无症状心肌梗塞与缺血性卒中的关系

2021-06-09 MedSci原创 MedSci原创

在基于社区的样本中,研究人员发现无症状MI与缺血性卒中之间存在关联。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在验证一个假设,即无症状MI是缺血性卒中的危险因素。研究人员在血管健康研究中评估了无症状MI与随后发生的缺血性卒中之间的关联。

心血管健康研究前瞻性招募了65岁以上的社区居民,研究人员纳入了没有卒中或MI的参与者。该研究的暴露因素为无症状和临床症状明显的、明显的MI。无症状MI被定义为心电图显示Q波的MI,且没有临床症状。

该研究的主要结局是缺血性卒中事件,次要结局是缺血性卒中亚型:非腔隙性、腔隙性和其他/未知类型卒中。在调整基线人口统计学和血管危险因素后,研究人员使用Cox比例风险分析对随时间变化的MI状态(无症状、明显或无MI)与卒中之间的关联进行了建模分析。

MI与卒中的关系

在4224名参与者中,362名(8.6%)参与者在9.8年的中位随访期间发生了无症状MI,421名 (10.0%)参与者发生了明显的MI,377名(8.9%)参与者发生了缺血性卒中。在调整人口统计学和合并症后,无症状MI与随后的缺血性卒中独立相关(HR为1.51;95%CI为1.03-2.21)。明显MI与短期(HR为80;95%CI为53-119)和长期(HR为1.60;95%CI为1.04-2.44)缺血性卒中相关。在次要分析中,无症状MI与卒中之间的关联仅限于非腔隙性缺血性卒中(HR为2.40;95%CI为1.36-4.22)。

由此可见,在基于社区的样本中,研究人员发现无症状MI与缺血性卒中之间存在关联。

原始出处:

Alexander E. Merkler.et al.Silent Myocardial Infarction and Subsequent Ischemic Stroke in the Cardiovascular Health Study.Neurology.2021.https://doi.org/10.1212/WNL.0000000000012249

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    2022-01-26 zhaojie88
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    2021-06-09 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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