Ann Rheum Dis:基线超声检查是幼年特发性关节炎(JIA)患者复发的可能预测指标

2018-02-09 xiangting MedSci原创

US异常是个体患者复发的强有力预测指标。无论如何治疗,US阳性患者与US阴性患者相比,急性发作的风险几乎高出4倍。

这项研究旨在探讨幼年特发性关节炎(JIA)患者中关节超声检查与临床检查的相关性,并评估临床无活动患者由超声检测的滑膜炎是否能够预测关节炎急性发作。

纳入88例连续性JIA患者,其中46例患者(52%)为持续性少关节炎,15例(17%)为延伸性少关节炎,15例(17%)为类风湿因子阴性多关节炎,12例(14%)为其他形式的JIA,全部临床不活动至少3个月。这些患者接受44个关节的超声(US)评估。在研究开始时筛查关节是否存在关节滑膜增生、关节积液和能量多普勒(PD)信号。临床随访4年。

20/88(22.7%)例患者和38/3872(0.98%)关节的US异常。延伸性少关节炎和类风湿因子阴性多关节炎在US阳性患者中比US阴性患者中更频繁(35.0%vs 11.8%,30.0%vs 13.2%,P=0.005)。在4年的随访期间,41/88(46.6%)例患者出现急性发作; 基线时26/68(38.2%)例为US阴性,15/20(75%)为US阳性。US检查异常,在校正治疗变动后,显著增加急性发作的风险(OR=3.8,95%CI 1.2至11.5)。灰度和PD异常的组合对复发显示出比单独灰度(33%,6/18)更高的预测价值(65%,13/20)。

US异常是个体患者复发的强有力预测指标。无论如何治疗,US阳性患者与US阴性患者相比,急性发作的风险几乎高出4倍。如果US异常,无论国际风湿病联盟和Wallace分类如何,都应仔细对患者进行随访。

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    2018-02-11 lmm397
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  5. [GetPortalCommentsPageByObjectIdResponse(id=2012576, encodeId=858320125e602, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Sep 17 10:34:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894652, encodeId=07bc1894652eb, content=<a href='/topic/show?id=e45b6e859f3' target=_blank style='color:#2F92EE;'>#特发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67859, encryptionId=e45b6e859f3, topicName=特发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Sat Jan 05 23:34:00 CST 2019, time=2019-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265634, encodeId=b58412656349c, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sun Feb 11 07:34:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1284298, encodeId=a98c1284298b9, content=<a href='/topic/show?id=d27a9280461' target=_blank style='color:#2F92EE;'>#超声检查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92804, encryptionId=d27a9280461, topicName=超声检查)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=649f191, createdName=zzc2211, createdTime=Sun Feb 11 07:34:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407020, encodeId=c5ab140e020a1, content=<a href='/topic/show?id=fa7c100231a5' target=_blank style='color:#2F92EE;'>#预测指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100231, encryptionId=fa7c100231a5, topicName=预测指标)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10c72588657, createdName=anminleiryan, createdTime=Sun Feb 11 07:34:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454999, encodeId=d1be145499964, content=<a href='/topic/show?id=923a10296b9' target=_blank style='color:#2F92EE;'>#JIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10296, encryptionId=923a10296b9, topicName=JIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c48e5623632, createdName=lujian, createdTime=Sun Feb 11 07:34:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286585, encodeId=e7f12865851a, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2emBzjO0FtqTJ05AqrEEdRmp6tmlsLXqpzfxWdtgbbgPGWRHagoK9fLTd3IayRPgkJVIVBWtdlmnkBhOIR4cFM/0, createdBy=e8d51649330, createdName=飘飘爱, createdTime=Fri Feb 09 19:12:15 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
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    2018-02-11 lujian
  7. [GetPortalCommentsPageByObjectIdResponse(id=2012576, encodeId=858320125e602, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Sep 17 10:34:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894652, encodeId=07bc1894652eb, content=<a href='/topic/show?id=e45b6e859f3' target=_blank style='color:#2F92EE;'>#特发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67859, encryptionId=e45b6e859f3, topicName=特发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Sat Jan 05 23:34:00 CST 2019, time=2019-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265634, encodeId=b58412656349c, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sun Feb 11 07:34:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1284298, encodeId=a98c1284298b9, content=<a href='/topic/show?id=d27a9280461' target=_blank style='color:#2F92EE;'>#超声检查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92804, encryptionId=d27a9280461, topicName=超声检查)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=649f191, createdName=zzc2211, createdTime=Sun Feb 11 07:34:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407020, encodeId=c5ab140e020a1, content=<a href='/topic/show?id=fa7c100231a5' target=_blank style='color:#2F92EE;'>#预测指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100231, encryptionId=fa7c100231a5, topicName=预测指标)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10c72588657, createdName=anminleiryan, createdTime=Sun Feb 11 07:34:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454999, encodeId=d1be145499964, content=<a href='/topic/show?id=923a10296b9' target=_blank style='color:#2F92EE;'>#JIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10296, encryptionId=923a10296b9, topicName=JIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c48e5623632, createdName=lujian, createdTime=Sun Feb 11 07:34:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286585, encodeId=e7f12865851a, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2emBzjO0FtqTJ05AqrEEdRmp6tmlsLXqpzfxWdtgbbgPGWRHagoK9fLTd3IayRPgkJVIVBWtdlmnkBhOIR4cFM/0, createdBy=e8d51649330, createdName=飘飘爱, createdTime=Fri Feb 09 19:12:15 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-02-09 飘飘爱

    很好

    0

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