J Rheumatol:全身型幼年特发性关节炎疾病活动性的测量项目核心集

2017-08-14 xiangting MedSci原创

目前还没有关于全身型幼年特发性关节炎(sJIA)的标准化疾病活动性评估工具。这项研究旨在为sJIA开发一套疾病活动性测量集。

目前还没有关于全身型幼年特发性关节炎(sJIA)的标准化疾病活动性评估工具。这项研究旨在为sJIA开发一套疾病活动性测量集。

对从加拿大3家机构招募的sJIA患者进行了验证研究。疾病活动性评分是基于调查问卷,临床因素和实验室检查的。医师的整体评估是标准。确定了每个项目与标准的关联强度。然后对国际专家进行了调查以确定前10大项目。最后使用专家的回答来产生一套拟议的疾病活动测量核心集。

共招收了57名受试者,其中26名为中或重度活动性,31名为轻度活动性或不活动。与标准最相关的项目是活动性关节数目(r = 0.79),父母对疾病活动总体评估(r = 0.53),红细胞沉降率(ESR; r = 0.62)和C-反应蛋白(CRP ; r = 0.61)。国际专家的回应率为82%(154/187)。投票数最多的项目,按照降序排列依次是活动性关节数目、前2周发热天数、患者和家长对疾病活动的整体评估、sJIA皮疹、ESR、CRP和血红蛋白水平。

这项研究提出了一套用于测量sJIA疾病活动性的项目核心集。未来的研究应该在国际背景下进一步验证这套核心集。

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    2017-08-16 lmm397

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