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J Periodontol：牙周膜来源的间充质干细胞通过旁分泌途径调节嗜中性粒细胞的反应

2019-01-24 lishiting MedSci原创

PDLSCsHL-60免疫反应
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间充质干细胞可以分化为不同的间充质细胞系，并调节免疫反应。这篇研究的目的是为了评估牙周膜来源的间充质干细胞(PDLSCs)是否可通过旁分泌途径调节嗜中性粒细胞的反应。

间充质干细胞可以分化为不同的间充质细胞系，并调节免疫反应。这篇研究的目的是为了评估牙周膜来源的间充质干细胞(PDLSCs)是否可通过旁分泌途径调节嗜中性粒细胞的反应。研究将富含CD105的PDLSCs培养24小时并施以牙龈卟啉单胞菌蛋白提取物(PgPE) (0 or 2ug/ml)刺激3小时。清洗细胞并再培养18小时后收集和储存上浮物。随后，对人前髓细胞性白血病来源的可分化为嗜中性粒细胞的HL-60细胞(HL60D)施以PDLSCs上浮物刺激，检测HL60D的活性和功能反应。结果显示，施以PgPE刺激会诱导PDLSCs分泌更多的炎症标记物和细胞因子，包括RANTES， 嗜酸细胞活化趋化因子， 干扰素(IFN)-γ-诱导蛋白10 (IP-10)， 单核细胞趋化蛋白-1 (MCP-1)， IFN-γ， 白细胞介素(IL)-6， IL-8和IL-1ra (p < 0.05)。当暴露于施加PgPE的PDLSCs上浮物时，HL-60D的募集率上调4.7 ± 1.09倍。存在PMA刺激的HL-60D情况下，施加PgPE的PDLSCs上浮物促进细胞内活性氧(ROS)产物上调1.78 ± 1.0

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    2019-07-04 feather89

    #PE#

    0

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    2019-12-29 h.y200607_23674418

    #间充质干细#

    0

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    2020-01-05 xqptu

    #牙周膜#

    0

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    2019-10-24 ms6829001416292975

    #嗜中性粒细胞#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1727855, encodeId=340f1e2785522, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Jul 04 19:01:00 CST 2019, time=2019-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815434, encodeId=3264181543422, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sun Dec 29 19:01:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755913, encodeId=3b491e55913ad, content=<a href='/topic/show?id=30f46e536d7' target=_blank style='color:#2F92EE;'>#牙周膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67536, encryptionId=30f46e536d7, topicName=牙周膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a6e37060729, createdName=xqptu, createdTime=Sun Jan 05 06:01:00 CST 2020, time=2020-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028994, encodeId=716520289945c, content=<a href='/topic/show?id=89a440214c2' target=_blank style='color:#2F92EE;'>#嗜中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40214, encryptionId=89a440214c2, topicName=嗜中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/F82CC4A89F97BD21D3DDB7AD5F2AD09D/100, createdBy=52952500022, createdName=ms6829001416292975, createdTime=Thu Oct 24 11:01:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682499, encodeId=46b61682499e7, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Thu Jun 13 14:01:00 CST 2019, time=2019-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296691, encodeId=bb5312966918f, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Sat Jan 26 11:01:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451102, encodeId=d478145110255, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Jan 26 11:01:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629918, encodeId=bc5016299187a, content=<a href='/topic/show?id=cb9c5881310' target=_blank style='color:#2F92EE;'>#旁分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58813, encryptionId=cb9c5881310, topicName=旁分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=422221388033, createdName=lfcmxl, createdTime=Sat Jan 26 11:01:00 CST 2019, time=2019-01-26, status=1, ipAttribution=)]
    2019-06-13 gwc392

    #分泌#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1727855, encodeId=340f1e2785522, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Jul 04 19:01:00 CST 2019, time=2019-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815434, encodeId=3264181543422, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sun Dec 29 19:01:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755913, encodeId=3b491e55913ad, content=<a href='/topic/show?id=30f46e536d7' target=_blank style='color:#2F92EE;'>#牙周膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67536, encryptionId=30f46e536d7, topicName=牙周膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a6e37060729, createdName=xqptu, createdTime=Sun Jan 05 06:01:00 CST 2020, time=2020-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028994, encodeId=716520289945c, content=<a href='/topic/show?id=89a440214c2' target=_blank style='color:#2F92EE;'>#嗜中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40214, encryptionId=89a440214c2, topicName=嗜中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/F82CC4A89F97BD21D3DDB7AD5F2AD09D/100, createdBy=52952500022, createdName=ms6829001416292975, createdTime=Thu Oct 24 11:01:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682499, encodeId=46b61682499e7, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Thu Jun 13 14:01:00 CST 2019, time=2019-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296691, encodeId=bb5312966918f, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Sat Jan 26 11:01:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451102, encodeId=d478145110255, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Jan 26 11:01:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629918, encodeId=bc5016299187a, content=<a href='/topic/show?id=cb9c5881310' target=_blank style='color:#2F92EE;'>#旁分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58813, encryptionId=cb9c5881310, topicName=旁分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=422221388033, createdName=lfcmxl, createdTime=Sat Jan 26 11:01:00 CST 2019, time=2019-01-26, status=1, ipAttribution=)]
    2019-01-26 yykkxiaodou

    #中性粒细胞#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1727855, encodeId=340f1e2785522, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Jul 04 19:01:00 CST 2019, time=2019-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815434, encodeId=3264181543422, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sun Dec 29 19:01:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755913, encodeId=3b491e55913ad, content=<a href='/topic/show?id=30f46e536d7' target=_blank style='color:#2F92EE;'>#牙周膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67536, encryptionId=30f46e536d7, topicName=牙周膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a6e37060729, createdName=xqptu, createdTime=Sun Jan 05 06:01:00 CST 2020, time=2020-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028994, encodeId=716520289945c, content=<a href='/topic/show?id=89a440214c2' target=_blank style='color:#2F92EE;'>#嗜中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40214, encryptionId=89a440214c2, topicName=嗜中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/F82CC4A89F97BD21D3DDB7AD5F2AD09D/100, createdBy=52952500022, createdName=ms6829001416292975, createdTime=Thu Oct 24 11:01:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682499, encodeId=46b61682499e7, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Thu Jun 13 14:01:00 CST 2019, time=2019-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296691, encodeId=bb5312966918f, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Sat Jan 26 11:01:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451102, encodeId=d478145110255, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Jan 26 11:01:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629918, encodeId=bc5016299187a, content=<a href='/topic/show?id=cb9c5881310' target=_blank style='color:#2F92EE;'>#旁分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58813, encryptionId=cb9c5881310, topicName=旁分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=422221388033, createdName=lfcmxl, createdTime=Sat Jan 26 11:01:00 CST 2019, time=2019-01-26, status=1, ipAttribution=)]
    2019-01-26 医者仁心

    #牙周#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1727855, encodeId=340f1e2785522, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Jul 04 19:01:00 CST 2019, time=2019-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815434, encodeId=3264181543422, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sun Dec 29 19:01:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755913, encodeId=3b491e55913ad, content=<a href='/topic/show?id=30f46e536d7' target=_blank style='color:#2F92EE;'>#牙周膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67536, encryptionId=30f46e536d7, topicName=牙周膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a6e37060729, createdName=xqptu, createdTime=Sun Jan 05 06:01:00 CST 2020, time=2020-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028994, encodeId=716520289945c, content=<a href='/topic/show?id=89a440214c2' target=_blank style='color:#2F92EE;'>#嗜中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40214, encryptionId=89a440214c2, topicName=嗜中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/F82CC4A89F97BD21D3DDB7AD5F2AD09D/100, createdBy=52952500022, createdName=ms6829001416292975, createdTime=Thu Oct 24 11:01:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682499, encodeId=46b61682499e7, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Thu Jun 13 14:01:00 CST 2019, time=2019-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296691, encodeId=bb5312966918f, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Sat Jan 26 11:01:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451102, encodeId=d478145110255, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Jan 26 11:01:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629918, encodeId=bc5016299187a, content=<a href='/topic/show?id=cb9c5881310' target=_blank style='color:#2F92EE;'>#旁分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58813, encryptionId=cb9c5881310, topicName=旁分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=422221388033, createdName=lfcmxl, createdTime=Sat Jan 26 11:01:00 CST 2019, time=2019-01-26, status=1, ipAttribution=)]
    2019-01-26 lfcmxl

    #旁分泌#

    0

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本研究旨在分析在牙周炎的氧化微环境中Nrf2介导的牙周膜干细胞抗凋亡（PDLSCs）的机制。使用H2O2治疗PDLSCs创建氧化应激模型。采用实时PCR，Western印迹法、TUNEL染色、荧光分析法和传递遗传学来确定氧化应激和细胞凋亡的程度以及转录因子NF-E2相关因子2（Nrf2）的功能。结果表明，H2O2处理后，氧化应激的作用十分明显，活性氧和丙二醛（MDA）的水平升高。暴露与H2O2后，