Stroke:谵妄对脑出血患者预后的影响

2021-10-06 MedSci原创 MedSci原创

大多数ICH患者的急性谵妄会在出院后消退,这与持续性谵妄患者相比具有更好的结局。谵妄对结局的影响可以通过急性后康复进一步减轻。

谵妄预示着脑出血(ICH)患者更差的预后,但尚不清楚症状缓解或急性期后治疗强度是否可以减轻其影响。

近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在探讨与出院前谵妄缓解相关的结局差异,以及出院后急性期潜在的介导作用。

研究人员对2年期间连续就诊的ICH患者进行了单中心队列研究。根据DSM-5标准诊断谵妄,并根据出院时谵妄状态进一步分类为持续性或消退两类。研究人员使用针对已知的ICH预测因子进行调整的Logistic回归模型确定了谵妄对不良的3个月结局(改良Rankin量表评分为4-6)的影响,然后使用介导分析通过急性出院后地区评估了谵妄的间接影响。

在590名患者(平均年龄为70.5±15.5岁,52%为男性,83%为白人)中,59%(n=348)患者在住院期间出现谵妄。年龄较大和ICH严重程度较高是谵妄的危险因素,但只有年龄较小才能预测谵妄消退,75%(161/215)的谵妄ICH幸存者发生这种情况。谵妄与不良结局密切相关,但持续性谵妄的患者比谵妄得到缓解的患者表现更差(调整比值比[OR]为7.3[95%CI为3.3-16.3])(调整OR为3.1[95%CI为1.8-5.5])。与专业治疗机构相比,谵妄患者出院接受住院康复治疗的可能性较小(调整后的OR为0.31[95%CI为0.17–0.59]),并且急性期后治疗场所在一定程度上调节了ICH幸存者谵妄与功能结局之间的关系,导致谵妄的影响降低了25%(无介导因素:调整后的OR为3.0[95%CI为1.7-5.6];有介导因素:调整后的OR为2.3[95%CI为1.2-4.3])。

由此可见,大多数ICH患者的急性谵妄会在出院后消退,这与持续性谵妄患者相比具有更好的结局。谵妄对结局的影响可以通过急性后康复进一步减轻。

原始出处:

Michael E. Reznik.et al.Impact of Delirium on Outcomes After Intracerebral Hemorrhage.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.034023

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    2021-10-07 老龙一点

    学习

    0

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    2021-10-07 李晓红

    谵妄可以通过康复解决

    0

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    2021-10-07 159jWWA9638

    0

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