J Clin Endocrinol Metab:激素治疗有益于绝经后女性的骨骼健康

2016-11-29 MedSci MedSci原创

骨质疏松症是一种渐进性疾病,骨骼变得更弱,更易折断。近日,发表于Journal of Clinical Endocrinology & Metabolism的一项新的研究表明,激素治疗可以改善骨质疏松症女性的骨健康。研究共纳入了1279名女性,年龄在50-80岁,将其分为三组:22%的女性接受绝经后激素疗法(MHT),30%的女性治疗前得益于MHT,48%的女性从未接受过MHT。科学家们使

骨质疏松症是一种渐进性疾病,骨骼变得更弱,更易折断。近日,发表于Journal of Clinical Endocrinology & Metabolism的一项新的研究表明,激素治疗可以改善骨质疏松症女性的骨健康。

研究共纳入了1279名女性,年龄在50-80岁,将其分为三组:22%的女性接受绝经后激素疗法(MHT),30%的女性治疗前得益于MHT,48%的女性从未接受过MHT。

科学家们使用双重X射线吸收测定(DXA)扫描患者腰椎,股骨颈和髋部来评估其骨矿物质密度。基于扫描的结果对参与者的骨小梁进行评分。骨小梁评分通常用于预测绝经后妇女的骨折风险。

研究中考虑的主要变量是年龄和体重指数(BMI)。该研究还校正了患者的骨折病史,及补充剂的摄入,如钙和维生素D

该研究第一次显示MHT可以改善骨的质量和结构。

此外,结果还表明,MHT带来的骨健康益处可持续至女性停止治疗后至少2年。

与过去曾接受过MHT和从没有接受过MHT治疗的患者相比,基线时期接受MHT治疗的患者其骨小梁的评分较高。

现在接受MHT治疗的患者其骨密度值明显较高。与从未接受MHT治疗的患者相比,曾接受MHT治疗的患者骨密度和骨微结构均较好。

绝经期激素治疗的持续时间不影响骨骼健康。

原始出处:

Georgios Papadakis et al., The benefit of menopausal hormone therapy on bone density and microarchitecture persists after its withdrawal. Journal of Clinical Endocrinology & Metabolism.17 November 2016.


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    2017-08-08 一闲
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likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Nov 30 09:05:27 CST 2016, time=2016-11-30, status=1, ipAttribution=)]
    2016-12-01 zxxiang
  8. 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likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Nov 30 09:05:27 CST 2016, time=2016-11-30, status=1, ipAttribution=)]
    2016-12-01 xiaotaiyang1

    激素疗法

    0

  9. 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likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Nov 30 09:05:27 CST 2016, time=2016-11-30, status=1, ipAttribution=)]
    2016-11-30 1e184d7bm65(暂无匿称)

    非常棒!

    0

  10. 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likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Nov 30 09:05:27 CST 2016, time=2016-11-30, status=1, ipAttribution=)]
    2016-11-30 ylzr123

    骨质疏松症是一种渐进性疾病,骨骼变得更弱,更易折断。激素治疗可以改善骨质疏松症女性的骨健康。绝经期激素治疗的持续时间不影响骨骼健康。

    0

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