Bone Joint J:基于MSIS标准的FDG PET在假体关节感染中的诊断作用

2020-05-31 MedSci原创 MedSci原创

全髋关节置换术(THA)中的人工关节感染(PJI)和无菌松动可出现疼痛和骨质疏松。肌肉骨骼感染协会(Musculoskeletal Infection Society,MSIS)提供了PJI的诊断标准

全髋关节置换术(THA)中的人工关节感染(PJI)和无菌松动可出现疼痛和骨质疏松。肌肉骨骼感染协会(Musculoskeletal Infection Society,MSIS)提供了PJI的诊断标准。本研究旨在根据目前MSIS对假体关节感染的定义,分析F18-氟脱氧葡萄糖(FDG)正电子发射断层扫描(PET)CT扫描在THA术前诊断脓性松解的实用性。

 

前瞻性研究共纳入了130例疼痛性单侧骨水泥化的THA患者,平均随访5.17年(sd 1.12)。平均患者年龄为67.5岁(SD 4.85)。术前评估与炎症标志物、抽吸和F18 FDG PET扫描。根据MSIS标准对PJI进行了诊断性的实用性检查,并进行了诊断性的检查,仅培养标本就有3例阳性。

 

结果显示,平均红细胞沉降率、C反应蛋白、白细胞计数分别为47.83 mm/h、25.21 mg/l、11.05×109/l。与MSIS标准相比,FDG PET的敏感性、特异性、准确性、阴性预测值、假阳性率分别为94.87%、38.46%、56.38%、94.59%、60.21%。FDG PET与单纯培养相比,FDG PET的假阳性率为77.4%。

 

该研究结果表明,FDG PET在疑似PJI的术前评估中具有明确的作用。这也是首次根据MSIS标准评估其效用,并与单纯微生物学结果进行比较的研究。然而,FDG PET具有较高的假阳性率。因此,我们认为F18 FDG PET在确认无感染方面是有用的,但如果阳性,可能不能确诊PJI。

 

原始出处:

 

M KiranT D Donnelly, et al., Diagnostic Utility of Fluorodeoxyglucose Positron Emission Tomography in Prosthetic Joint Infection Based on MSIS Criteria. Bone Joint J. 2019 Aug;101-B(8):910-914. doi: 10.1302/0301-620X.101B8.BJJ-2018-0929.R2.

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    2020-11-27 apoenzyme
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    2021-04-08 feather89
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    2020-06-02 小几洁

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