Cardiovasc Diabetol:糖尿病与房颤类型有何关联?一项来自BMC的系统评价和荟萃分析

2021-12-27 MedSci原创 MedSci原创

糖尿病与非阵发性房颤密切相关,而不是阵发性房颤。

心房颤动 (AF) 是一种常见的心律失常,分为阵发性和非阵发性。非阵发性房颤与并发症风险增加有关。糖尿病可增加AF的发生,但其在AF维持中的作用尚不清楚。为此研究者进行了系统评价和荟萃分析,以总结关于糖尿病与AF类型的关联。

研究组一共在5个数据库中搜索了糖尿病与人类房颤(与其他类型相比)可能性的观察性研究。采用纽卡斯尔-渥太华量表评估研究质量。将AF类型分为阵发性和非阵发性,并采用随机效应模型进行荟萃分析。

在确定的 1997 篇文章中,20 篇被纳入系统评价。人口样本大小从 64 到 9816 名参与者不等,平均年龄从 40 到 75 岁不等,女性比例从 24.8% 到 100%。研究质量从差 (60%) 到一般 (5%) 再到好 (35%)。在系统评价中,8 项针对 AF 患者的研究调查了糖尿病与非阵发性 AF(vs 阵发性)的横断面关联,其中 6 项显示正相关,2 项显示无关联。14 项研究调查了糖尿病与“更持续”的 AF 类型(相对于“持续时间更短”)的纵向关联,其中 2 项显示正相关,12 项显示无关联。

糖尿病与非阵发性房颤(与阵发性房颤)的横断面相关性。如果研究评估糖尿病与房颤患者发生非阵发性房颤(与阵发性房颤)的横断面关联,则纳入meta分析

在横断面研究的荟萃分析中,伴有房颤和糖尿病的患者发生非阵发性房颤的可能性是无糖尿病患者的1.31倍纵向研究的meta分析表明,对于阵发性房颤患者,糖尿病与进展为非阵发性房颤的可能性增加1.32倍相关[5项研究;综合OR (95% CI), 1.32 (1.07-1.62);I2 = 0%)。

糖尿病与非阵发性 AF(与阵发性 AF)的纵向关联。如果研究评估了糖尿病与阵发性 AF 患者发生非阵发性 AF(与阵发性 AF)的可能性纵向关联,则这些研究被纳入荟萃分析

总的研究结果表明,糖尿病与非阵发性房颤密切相关,而不是阵发性房颤。然而,仍然需要进一步的高质量研究来进一步证实这些发现。

 参考文献:Alijla, F., Buttia, C., Reichlin, T. et al. Association of diabetes with atrial fibrillation types: a systematic review and meta-analysis. Cardiovasc Diabetol 20, 230 (2021). https://doi.org/10.1186/s12933-021-01423-2

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    2022-02-24 venlin
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    2021-12-20 huagfeg

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