Semin Arthritis Rheu:间质性肺病类型对类风湿性关节炎死亡率的影响

2019-12-23 xiangting MedSci原创

这项研究通过系统的文献综述和荟萃分析发现,与其他RA-ILD类型相比,UIP类型与RA-ILD的死亡风险较高相关。

间质性肺病(ILD)是类风湿性关节炎(RA)一个重要的关节外症状。RA患者普通型间质性肺炎(UIP)类型与死亡率之间的关系尚不清楚。这项研究目的是对RA-ILD类型与死亡风险的关联进行系统文献综述和荟萃分析。

20181212日以前发表的研究进行了系统的文献综述。从确定的研究中提取研究特征、ILD类型的未调整和调整死亡率相对风险(RR),并进行质量评估。使用逆方差加权和随机效应模型汇总死亡率的RRRA-UIP vs.其他RA-ILD)。

10项回顾性队列研究符合入选标准。共包括1256RA-ILD患者,其中484例死亡。荟萃分析显示,与其他类型相比,UIP RA-ILD患者死亡的合并RR1.6695%置信区间1.07-2.56)。在比较RA-ILDUIPNSIP类型的亚组分析中,RR2.3995CI0.86-6.68)。

尽管最近的研究强调肺生理学的重要性和将肺受累程度作为死亡率的重要预测指标,而不是RA-ILD类型,但这项研究通过系统的文献综述和荟萃分析发现,与其他RA-ILD类型相比,UIP类型与RA-ILD的死亡风险较高相关。由于满足条件的研究很少和混杂因素不一致,未来需要对各种RAILD和患者相关因素进行标准化评估来进一步研究RA-ILD的死亡风险。

原始出处:

Namrata Singh. Impact of the pattern of interstitial lung disease on mortality in rheumatoid arthritis: A systematic literature review and meta-analysis. Semin Arthritis Rheu. December 2019.

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    2020-05-08 amy0559
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    2019-12-25 lmm397
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    2019-12-25 zhaojie88
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