BMJ:113名新冠肺炎死亡病例临床特征研究

2020-03-28 网络 网络

研究发现,新冠肺炎病毒可引起肺部和全身炎症,导致高危患者出现多器官衰竭,死亡患者的常见的严重并发症包括,急性呼吸窘迫综合征、呼吸衰竭、脓毒症、急性心脏损伤和心力衰竭

近日研究人员描述了冠状病毒病2019(Covid-19)死亡患者的临床特征
 
研究在中国武汉同济医院开展,截至2020年2月28日,其中死亡患者113例,治愈出院161例,从电子病历中提取相关资料。
 
研究发现,死亡患者的年龄显著高于治愈出院患者(68 vs 51岁),男性患者的死亡风险较高,男性死亡患者83例,占73%,男性治愈患者88例,占55%。死亡患者中,最常见的共病为高血压和其他心血管疾病,其中死亡患者中高血压患者54例(48%),其他心血管疾病16例(14%);而治愈患者中高血压39例(24%),其他心血管疾病7例(4%)。死亡患者最常见的症状包括呼吸困难(70例,62%)、胸闷(55例,49%)和意识障碍(25例,22%),而治愈患者中上述症状分别只有50例(31%)、48例(30%)以及1例(1%)。平均症状出现到患者死亡时间为16天。56例死亡患者(50%)出现白细胞增多,而治愈患者中仅6例(4%),而死亡和治愈患者中,淋巴细胞减少症状分别为103例(91%)和76例(47%)。死亡病例中,丙氨酸氨基转移酶、天冬氨酸转氨酶、肌酐、肌酸激酶、乳酸脱氢酶、肌钙蛋白I、N端前脑钠肽和d-二聚体的浓度显著高于治愈患者。死亡患者的常见并发症包括急性呼吸窘迫综合征(113例,100%)、I型呼吸衰竭(18例,51%)、脓毒症(113例,100%)、急性心脏损伤(72例,77%)、心力衰竭(41例,49%)、碱中毒(14例,40%)、高钾血症(42例,37%)、急性肾损伤(28例,25%)和缺氧性脑病(23例,20%)。伴有心血管共病患者出现心血管并发症风险较高,但无论心血管疾病史,急性心脏损伤和心力衰竭在死亡患者中更为常见。
 
研究发现,新冠肺炎病毒可引起肺部和全身炎症,导致高危患者出现多器官衰竭,死亡患者的常见的严重并发症包括,急性呼吸窘迫综合征、呼吸衰竭、脓毒症、急性心脏损伤和心力衰竭。
 
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    2021-03-13 gaoxiaoe
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    2020-03-28 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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    2020-03-28 1226a71am04(暂无昵称)

    学习了

    0

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    2020-03-28 执迷不悔

    学习了

    0

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