J Endod:负载抗生素壳聚糖水凝胶作为牙髓再生支架的抗微生物活性和生物相容性

2020-09-18 lishiting 网络

这篇研究的目的是为了评估数种负载抗生素水凝胶支架对粪肠球菌的作用以及刺激牙髓干细胞(DPSCs)增殖与分化的能力。

这篇研究的目的是为了评估数种负载抗生素水凝胶支架对粪肠球菌的作用以及刺激牙髓干细胞(DPSCs)增殖与分化的能力。

研究采用12.5 mg/mL纤维蛋白素原和0.4% (w/v)壳聚糖制备纤维蛋白(Fg)或壳聚糖纤维蛋白水凝胶(Ch)。将3倍抗生素、克林霉素改良的3联抗生素糊剂或双倍抗生素整合入凝胶中(1mg/mL)。采用菌落形成单位(CFU)和激光共聚焦显微镜(CLSM)检测其对粪肠球菌生物膜的抗微生物活性。将细胞负载入不同凝胶,在7和14天通过水溶性tetrazolium salt-1细胞活力检测和Live & Dead细胞检测评估细胞活力和形态变化。采用ALP和茜素红染色检测矿化情况。

结果显示,与阳性对照相比,单独负载抗生素Fg凝胶和Ch凝胶的CFUs显著减少(P<0.05)。当抗生素负载入Ch凝胶时,任何组中均未检测到CFUs (p<0.05)。CLSM影像显示,在负载抗生素的Ch组牙本质表面上存在密集的红色区域伴随几乎全部的死菌,与其他组相比存在明显减少的活菌(p<0.05)。3倍抗生素负载的Fg和Ch凝胶与其他凝胶组相比,矿化结节形成急剧下降(p<0.05)。Ch水凝胶使细胞形态呈圆形达7天以上。与其他抗生素负载的Ch组相比,单独Ch或伴随双倍抗生素糊剂的凝胶在14天具有更多伸展呈纺锤形态的细胞以及更高的碱性磷酸酶活性(p>0.05)。

结论:与其他支架相比,双倍抗生素负载的Ch凝胶能够增加抗菌性并维持更高的细胞活性、细胞伸展和矿化活性。

原始出处:

Hacer Aksel, Faranak Mahjour, et al. Antimicrobial Activity and Biocompatibility of Antibiotic-loaded Chitosan Hydrogels as a Potential Scaffold in Regenerative Endodontic Treatment. J Endod. 2020 Sep 14;S0099-2399(20)30689-0. doi: 10.1016/j.joen.2020.09.007.

 

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    2020-10-30 jxrzshh
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    2020-11-11 ms3000001774039970

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1825203, encodeId=cc60182520372, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Nov 03 21:12:06 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669881, encodeId=ff6d1669881c4, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Fri Oct 30 07:12:06 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898465, encodeId=41e689846558, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/386c9473e2f8416994ecd304498508c3/4e42c95ba2404ac4bad380a4d36007ed.jpg, createdBy=5f8c5409505, createdName=ms3000001774039970, createdTime=Wed Nov 11 15:08:49 CST 2020, time=2020-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308078, encodeId=91ec13080e85a, content=<a href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417535, encodeId=7a39141e53591, content=<a href='/topic/show?id=84ff6e663c4' target=_blank style='color:#2F92EE;'>#牙髓再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67663, encryptionId=84ff6e663c4, topicName=牙髓再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0cf73291723, createdName=zhixianchen, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461061, encodeId=f5da146106169, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582445, encodeId=e44915824455e, content=<a href='/topic/show?id=bda942398cd' target=_blank style='color:#2F92EE;'>#壳聚糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42398, encryptionId=bda942398cd, topicName=壳聚糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f716920725, createdName=dlwang_26703132, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586647, encodeId=877d158664ec7, content=<a href='/topic/show?id=155269406ec' target=_blank style='color:#2F92EE;'>#生物相容性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69406, encryptionId=155269406ec, topicName=生物相容性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6cb17357412, createdName=bnurmamat, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886461, encodeId=1f668864610c, content=学习学习了,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Fri Sep 18 20:13:52 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-20 tastas
  5. [GetPortalCommentsPageByObjectIdResponse(id=1825203, encodeId=cc60182520372, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Nov 03 21:12:06 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669881, encodeId=ff6d1669881c4, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Fri Oct 30 07:12:06 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898465, encodeId=41e689846558, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/386c9473e2f8416994ecd304498508c3/4e42c95ba2404ac4bad380a4d36007ed.jpg, createdBy=5f8c5409505, createdName=ms3000001774039970, createdTime=Wed Nov 11 15:08:49 CST 2020, time=2020-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308078, encodeId=91ec13080e85a, content=<a href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417535, encodeId=7a39141e53591, content=<a href='/topic/show?id=84ff6e663c4' target=_blank style='color:#2F92EE;'>#牙髓再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67663, encryptionId=84ff6e663c4, topicName=牙髓再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0cf73291723, createdName=zhixianchen, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461061, encodeId=f5da146106169, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582445, encodeId=e44915824455e, content=<a href='/topic/show?id=bda942398cd' target=_blank style='color:#2F92EE;'>#壳聚糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42398, encryptionId=bda942398cd, topicName=壳聚糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f716920725, createdName=dlwang_26703132, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586647, encodeId=877d158664ec7, content=<a href='/topic/show?id=155269406ec' target=_blank style='color:#2F92EE;'>#生物相容性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69406, encryptionId=155269406ec, topicName=生物相容性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6cb17357412, createdName=bnurmamat, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886461, encodeId=1f668864610c, content=学习学习了,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Fri Sep 18 20:13:52 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1825203, encodeId=cc60182520372, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Nov 03 21:12:06 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669881, encodeId=ff6d1669881c4, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Fri Oct 30 07:12:06 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898465, encodeId=41e689846558, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/386c9473e2f8416994ecd304498508c3/4e42c95ba2404ac4bad380a4d36007ed.jpg, createdBy=5f8c5409505, createdName=ms3000001774039970, createdTime=Wed Nov 11 15:08:49 CST 2020, time=2020-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308078, encodeId=91ec13080e85a, content=<a href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417535, encodeId=7a39141e53591, content=<a href='/topic/show?id=84ff6e663c4' target=_blank style='color:#2F92EE;'>#牙髓再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67663, encryptionId=84ff6e663c4, topicName=牙髓再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0cf73291723, createdName=zhixianchen, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461061, encodeId=f5da146106169, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582445, encodeId=e44915824455e, content=<a href='/topic/show?id=bda942398cd' target=_blank style='color:#2F92EE;'>#壳聚糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42398, encryptionId=bda942398cd, topicName=壳聚糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f716920725, createdName=dlwang_26703132, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586647, encodeId=877d158664ec7, content=<a href='/topic/show?id=155269406ec' target=_blank style='color:#2F92EE;'>#生物相容性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69406, encryptionId=155269406ec, topicName=生物相容性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6cb17357412, createdName=bnurmamat, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886461, encodeId=1f668864610c, content=学习学习了,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Fri Sep 18 20:13:52 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-20 lishizhe
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  8. [GetPortalCommentsPageByObjectIdResponse(id=1825203, encodeId=cc60182520372, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Nov 03 21:12:06 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669881, encodeId=ff6d1669881c4, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Fri Oct 30 07:12:06 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898465, encodeId=41e689846558, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/386c9473e2f8416994ecd304498508c3/4e42c95ba2404ac4bad380a4d36007ed.jpg, createdBy=5f8c5409505, createdName=ms3000001774039970, createdTime=Wed Nov 11 15:08:49 CST 2020, time=2020-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308078, encodeId=91ec13080e85a, content=<a href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417535, encodeId=7a39141e53591, content=<a href='/topic/show?id=84ff6e663c4' target=_blank style='color:#2F92EE;'>#牙髓再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67663, encryptionId=84ff6e663c4, topicName=牙髓再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0cf73291723, createdName=zhixianchen, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461061, encodeId=f5da146106169, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582445, encodeId=e44915824455e, content=<a href='/topic/show?id=bda942398cd' target=_blank style='color:#2F92EE;'>#壳聚糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42398, encryptionId=bda942398cd, topicName=壳聚糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f716920725, createdName=dlwang_26703132, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586647, encodeId=877d158664ec7, content=<a href='/topic/show?id=155269406ec' target=_blank style='color:#2F92EE;'>#生物相容性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69406, encryptionId=155269406ec, topicName=生物相容性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6cb17357412, createdName=bnurmamat, createdTime=Sun Sep 20 10:12:06 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886461, encodeId=1f668864610c, content=学习学习了,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Fri Sep 18 20:13:52 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
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    2020-09-18 易水河

    学习学习了,不错

    0

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