Sci Transl Med:视网膜色素上皮细胞移植有望治疗干性年龄相关性黄斑变性

2018-04-09 药明康德 学术经纬

干性年龄相关性黄斑变性(dry age related macular degeneration, dry AMD)是由于视网膜色素上皮 (retinal pigmented epithelium, RPE) 细胞退化并死亡导致中央视力下降的慢性眼病。它是导致中老年人视力下降的重大原因,而且随着社会老龄化趋势的上升,它的发病率也不断升高。

干性年龄相关性黄斑变性(dry age related macular degeneration, dry AMD)是由于视网膜色素上皮 (retinal pigmented epithelium, RPE) 细胞退化并死亡导致中央视力下降的慢性眼病。它是导致中老年人视力下降的重大原因,而且随着社会老龄化趋势的上升,它的发病率也不断升高。南加州大学(University of Southern California)和加州其它大学、医院和研究单位的研究人员联合开发出一种基于干细胞技术的RPE移植体。这种移植体让由人类胚胎干细胞分化而成的RPE细胞在人工合成的骨架上形成一层单细胞膜。然后将RPE单细胞膜和骨架移植到干性AMD患者视网膜中RPE细胞缺失的位置。临床试验表明这种移植体能够安全地整合到视网膜中,并且不但可以防止患者视力进一步退化,还可以给某些患者的视力带来显着改善。这一技术有望恢复晚期干性AMD患者的视力,并且可以用于防止早期AMD患者出现视力下降。

原始出处:

Amir H. Kashani,et al.A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration.Sci Transl Med.04 Apr 2018:Vol. 10, Issue 435, eaao4097

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    2018-09-02 sunylz
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replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Thu Mar 21 06:49:00 CST 2019, time=2019-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810983, encodeId=26fe181098315, content=<a href='/topic/show?id=560e86e092b' target=_blank style='color:#2F92EE;'>#色素上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86709, encryptionId=560e86e092b, topicName=色素上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Sat Mar 23 20:49:00 CST 2019, time=2019-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810952, encodeId=cb5c181095201, content=<a href='/topic/show?id=bf4486e08be' target=_blank style='color:#2F92EE;'>#色素上皮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86708, encryptionId=bf4486e08be, topicName=色素上皮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Thu Jun 28 23:49:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837488, encodeId=4cd1183e488dc, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Tue Feb 12 11:49:00 CST 2019, time=2019-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658859, encodeId=cac51658859e6, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Sun Oct 21 21:49:00 CST 2018, time=2018-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270039, encodeId=646712e0039a1, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Wed Apr 11 05:49:00 CST 2018, time=2018-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376749, encodeId=58d413e67496a, content=<a href='/topic/show?id=5a7f4901672' target=_blank style='color:#2F92EE;'>#年龄相关性黄斑变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49016, encryptionId=5a7f4901672, topicName=年龄相关性黄斑变性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f3a0392, createdName=lingqf, createdTime=Wed Apr 11 05:49:00 CST 2018, time=2018-04-11, status=1, ipAttribution=)]
    2019-03-21 bsmagic9140
  5. 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target=_blank style='color:#2F92EE;'>#色素上皮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86708, encryptionId=bf4486e08be, topicName=色素上皮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Thu Jun 28 23:49:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837488, encodeId=4cd1183e488dc, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Tue Feb 12 11:49:00 CST 2019, time=2019-02-12, status=1, ipAttribution=), 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  6. 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target=_blank style='color:#2F92EE;'>#色素上皮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86708, encryptionId=bf4486e08be, topicName=色素上皮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Thu Jun 28 23:49:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837488, encodeId=4cd1183e488dc, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Tue Feb 12 11:49:00 CST 2019, time=2019-02-12, status=1, ipAttribution=), 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  7. 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  8. 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  9. 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    2018-04-11 zutt
  10. 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