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Neurology：妊娠早期丙戊酸盐暴露剂量与特定类型胎儿畸形相关

2013-08-08 高晓方 译 cmt

丙戊酸盐胎儿畸形脊柱裂尿道下裂
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澳大利亚一项研究表明，与其他胎儿畸形相比，减少妊娠早期丙戊酸盐暴露剂量可对脊柱裂和尿道下裂产生更为显著的防护效应。论文8月2日在线发表于《神经病学》（Neurology）。 此项研究对来自于澳大利亚妊娠期抗癫痫药登记系统的数据进行了分析。评估宫内丙戊酸盐暴露后代的特定类型胎儿畸形，并与妊娠早期孕母所用丙戊酸盐剂量进行相关性分析。 结果显示，与其他畸形相比，后代伴有脊柱裂和尿道下裂的孕母在妊娠早

澳大利亚一项研究表明，与其他胎儿畸形相比，减少妊娠早期丙戊酸盐暴露剂量可对脊柱裂和尿道下裂产生更为显著的防护效应。论文8月2日在线发表于《神经病学》（Neurology）。

此项研究对来自于澳大利亚妊娠期抗癫痫药登记系统的数据进行了分析。评估宫内丙戊酸盐暴露后代的特定类型胎儿畸形，并与妊娠早期孕母所用丙戊酸盐剂量进行相关性分析。

结果显示，与其他畸形相比，后代伴有脊柱裂和尿道下裂的孕母在妊娠早期所用丙戊酸盐平均剂量较高（P<0.05）。登记系统中孕母所用丙戊酸盐整体平均剂量在研究最后5年呈降低趋势，并伴有同时期脊柱裂和尿道下裂发生率显著降低，但其他畸形则无此变化。

Vajda FJ, O'Brien TJ, Graham JE, Lander CM, Eadie MJ.Dose dependence of fetal malformations associated with valproate.Neurology. 2013 Aug 2. [Epub ahead of print]

PMID:
23911758

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    2014-01-16 yinhl1978

    #Neurol#

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    2014-07-06 ms6829001416292975

    #特定类型#

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    2013-11-22 lsj628

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    2013-08-10 wushaoling

    #畸形#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1999329, encodeId=e681199932921, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Jan 16 05:22:00 CST 2014, time=2014-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798026, encodeId=12cf1e98026f1, content=<a href='/topic/show?id=26c56e923f7' target=_blank style='color:#2F92EE;'>#特定类型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67923, encryptionId=26c56e923f7, topicName=特定类型)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/F82CC4A89F97BD21D3DDB7AD5F2AD09D/100, createdBy=52952500022, createdName=ms6829001416292975, createdTime=Sun Jul 06 09:22:00 CST 2014, time=2014-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043675, encodeId=e8f020436e599, content=<a href='/topic/show?id=147b20908be' target=_blank style='color:#2F92EE;'>#丙戊酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20908, encryptionId=147b20908be, topicName=丙戊酸盐)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Fri Nov 22 13:22:00 CST 2013, time=2013-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362099, encodeId=f94313620991a, content=<a href='/topic/show?id=9857e03444b' target=_blank style='color:#2F92EE;'>#畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70344, encryptionId=9857e03444b, topicName=畸形)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Sat Aug 10 06:22:00 CST 2013, time=2013-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420925, encodeId=f40114209255b, content=<a href='/topic/show?id=dd994486468' target=_blank style='color:#2F92EE;'>#妊娠早期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44864, encryptionId=dd994486468, topicName=妊娠早期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=578b3632339, createdName=dongjia2011, createdTime=Sat Aug 10 06:22:00 CST 2013, time=2013-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507575, encodeId=9740150e5754d, content=<a href='/topic/show?id=adee2090e8b' target=_blank style='color:#2F92EE;'>#丙戊酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20907, encryptionId=adee2090e8b, topicName=丙戊酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46789929366, createdName=steven_u5, createdTime=Sat Aug 10 06:22:00 CST 2013, time=2013-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581575, encodeId=6a3d15815e5d2, content=<a href='/topic/show?id=134f8361e77' target=_blank style='color:#2F92EE;'>#胎儿畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83617, encryptionId=134f8361e77, topicName=胎儿畸形)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5d1416824653, createdName=ms1756883563247400, createdTime=Sat Aug 10 06:22:00 CST 2013, time=2013-08-10, status=1, ipAttribution=)]
    2013-08-10 dongjia2011

    #妊娠早期#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1999329, encodeId=e681199932921, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Jan 16 05:22:00 CST 2014, time=2014-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798026, encodeId=12cf1e98026f1, content=<a href='/topic/show?id=26c56e923f7' target=_blank style='color:#2F92EE;'>#特定类型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67923, encryptionId=26c56e923f7, topicName=特定类型)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/F82CC4A89F97BD21D3DDB7AD5F2AD09D/100, createdBy=52952500022, createdName=ms6829001416292975, createdTime=Sun Jul 06 09:22:00 CST 2014, time=2014-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043675, encodeId=e8f020436e599, content=<a href='/topic/show?id=147b20908be' target=_blank style='color:#2F92EE;'>#丙戊酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20908, encryptionId=147b20908be, topicName=丙戊酸盐)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Fri Nov 22 13:22:00 CST 2013, time=2013-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362099, encodeId=f94313620991a, content=<a href='/topic/show?id=9857e03444b' target=_blank style='color:#2F92EE;'>#畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70344, encryptionId=9857e03444b, topicName=畸形)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Sat Aug 10 06:22:00 CST 2013, time=2013-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420925, encodeId=f40114209255b, content=<a href='/topic/show?id=dd994486468' target=_blank style='color:#2F92EE;'>#妊娠早期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44864, encryptionId=dd994486468, topicName=妊娠早期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=578b3632339, createdName=dongjia2011, createdTime=Sat Aug 10 06:22:00 CST 2013, time=2013-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507575, encodeId=9740150e5754d, content=<a href='/topic/show?id=adee2090e8b' target=_blank style='color:#2F92EE;'>#丙戊酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20907, encryptionId=adee2090e8b, topicName=丙戊酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46789929366, createdName=steven_u5, createdTime=Sat Aug 10 06:22:00 CST 2013, time=2013-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581575, encodeId=6a3d15815e5d2, content=<a href='/topic/show?id=134f8361e77' target=_blank style='color:#2F92EE;'>#胎儿畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83617, encryptionId=134f8361e77, topicName=胎儿畸形)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5d1416824653, createdName=ms1756883563247400, createdTime=Sat Aug 10 06:22:00 CST 2013, time=2013-08-10, status=1, ipAttribution=)]
    2013-08-10 steven_u5

    #丙戊酸#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1999329, encodeId=e681199932921, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Jan 16 05:22:00 CST 2014, time=2014-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798026, encodeId=12cf1e98026f1, content=<a href='/topic/show?id=26c56e923f7' target=_blank style='color:#2F92EE;'>#特定类型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67923, encryptionId=26c56e923f7, topicName=特定类型)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/F82CC4A89F97BD21D3DDB7AD5F2AD09D/100, createdBy=52952500022, createdName=ms6829001416292975, createdTime=Sun Jul 06 09:22:00 CST 2014, time=2014-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043675, encodeId=e8f020436e599, content=<a href='/topic/show?id=147b20908be' target=_blank style='color:#2F92EE;'>#丙戊酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20908, encryptionId=147b20908be, topicName=丙戊酸盐)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Fri Nov 22 13:22:00 CST 2013, time=2013-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362099, encodeId=f94313620991a, content=<a href='/topic/show?id=9857e03444b' target=_blank style='color:#2F92EE;'>#畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70344, encryptionId=9857e03444b, topicName=畸形)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Sat Aug 10 06:22:00 CST 2013, time=2013-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420925, encodeId=f40114209255b, content=<a href='/topic/show?id=dd994486468' target=_blank style='color:#2F92EE;'>#妊娠早期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44864, encryptionId=dd994486468, topicName=妊娠早期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=578b3632339, createdName=dongjia2011, createdTime=Sat Aug 10 06:22:00 CST 2013, time=2013-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507575, encodeId=9740150e5754d, content=<a href='/topic/show?id=adee2090e8b' target=_blank style='color:#2F92EE;'>#丙戊酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20907, encryptionId=adee2090e8b, topicName=丙戊酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46789929366, createdName=steven_u5, createdTime=Sat Aug 10 06:22:00 CST 2013, time=2013-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581575, encodeId=6a3d15815e5d2, content=<a href='/topic/show?id=134f8361e77' target=_blank style='color:#2F92EE;'>#胎儿畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83617, encryptionId=134f8361e77, topicName=胎儿畸形)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5d1416824653, createdName=ms1756883563247400, createdTime=Sat Aug 10 06:22:00 CST 2013, time=2013-08-10, status=1, ipAttribution=)]
    2013-08-10 ms1756883563247400

    #胎儿畸形#

    0

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