Stroke:缺血性卒中女性患左心房纤维化的比例高于男性

2018-10-08 xing.T MedSci原创

由此可见,在控制诸如AF和年龄等混杂因素后,女性与左心房纤维化独立相关。需要进一步的研究来了解相比于男性这是否会导致女性AF相关的卒中风险增加。

女性房颤(AF)患者发生卒中的风险高于男性AF患者。心房纤维化是心房疾病的标志,其在AF出现之前增加了缺血性卒中的风险。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在明确女性在卒中患者中是否与左心房纤维化独立相关。

研究人员前瞻性地纳入了50岁以上的缺血性卒中患者,并进行晚期钆增强心脏磁共振成像以量化左心房纤维化的严重程度及其分布的心房壁模式。研究人员进行多变量线性回归分析以确定在调整潜在的混杂因素(AF和年龄)后,女性是否与左心房纤维化独立相关。

一百二十四名患者符合准入标准;最终纳入117名患者(通过心脏磁共振成像鉴定为心肌病而排除了7名患者)。全部患者都有可用的心脏磁共振成像数据。53名患者(45.3%)为女性。女性年龄较大,并且较少接受血管紧张素转换酶抑制剂治疗。91名患者存在任何程度的心房纤维化。女性患心房纤维化的比例高于男性-中位数(四分位数间)为18%(17) vs. 10%(20)。在针对人口统计学指标、药物治疗、房颤、合并症和心脏参数调整后的多变量线性回归模型中,研究人员发现女性与左心房纤维化独立相关。控制混杂因素后,女性患左心房纤维化的比例高于男性(95%CI为0.70-8.71%; P=0.02)。

由此可见,在控制诸如AF和年龄等混杂因素后,女性与左心房纤维化独立相关。需要进一步的研究来了解相比于男性这是否会导致女性AF相关的卒中风险增加。

原始出处:

Ana Catarina Fonseca,et al. Women Who Have Ischemic Strokes Have a Higher Burden of Left Atrial Fibrosis Than Men A Cardiac Magnetic Resonance Study.Stroke. 2018. https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.022105

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    2019-04-03 ylz8411
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    2018-10-10 sodoo
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    2018-10-08 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2018-10-08 医者仁心5538

    学习了

    0

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