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ACS Appl Mater Interfaces：P34HB/GO支架可较好的促进骨再生

2018-01-30 MedSci MedSci原创

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骨组织工程是作为实现组织再生的有利技术出现。应用于骨组织再生的支架必须表现出良好的生物力学性能，而仅有聚合物其表现不佳。迫切需要开发具有高成骨能力的新型生物材料。 在这项研究中，研究人员成功制备并表征了电纺聚（3-羟基丁酸酯 - 共-4-羟基丁酸酯）/氧化石墨烯（P34HB/GO）纳米纤维支架。研究GO含量对支架形态、生物力学性质和细胞行为的影响。 结果显示，GO可减少纤维直径并增强

骨组织工程是作为实现组织再生的有利技术出现。应用于骨组织再生的支架必须表现出良好的生物力学性能，而仅有聚合物其表现不佳。迫切需要开发具有高成骨能力的新型生物材料。

在这项研究中，研究人员成功制备并表征了电纺聚（3-羟基丁酸酯 - 共-4-羟基丁酸酯）/氧化石墨烯（P34HB/GO）纳米纤维支架。研究GO含量对支架形态、生物力学性质和细胞行为的影响。

结果显示，GO可减少纤维直径并增强孔隙率、亲水性、力学性能、细胞性能和支架的成骨分化。P34HB/GO在大鼠颅骨缺损的体内骨再生中效果优于P34HB。研究人员认为，本研究是第一个评估电纺P34HB/GO支架体内骨骼修复能力的研究。

综上所述，该研究结果表明，P34HB/GO支架具有制备工艺简单、多孔结构良好、生物力学性能优良、成骨能力快等优点，在骨组织工程应用中具有实际应用的潜力。

原始出处：

Zhou T, Li G, et al., Electrospun Poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/Graphene Oxide Scaffold: Enhanced Properties and Promoted in Vivo Bone Repair in Rats. ACS Appl Mater Interfaces. 2017 Dec 13;9(49):42589-42600. doi: 10.1021/acsami.7b14267.

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    2018-11-13 夏天与十三菇凉

    #FAC#

    0

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    2018-03-08 shanyongle

    #ACE#

    0

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    2018-02-01 yaanren

    #ACS#

    0

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    2018-02-01 lsj630

    #骨再生#

    0

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    2018-01-30 有备才能无患

    骨组织工程是作为实现组织再生的有利技术出现.应用于骨组织再生的支架必须表现出良好的生物力学性能.而仅有聚合物其表现不佳.迫切需要开发具有高成骨能力的新型生物材料

    0

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    2018-01-30 清风拂面

    谢谢分享学习

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