Chron Respir Dis:步行试验可预测慢阻肺患者血氧饱和度下降

2014-12-11 阮秀荣 医学论坛网

发生夜间氧饱和度下降(NOD)的慢性阻塞性肺病(COPD)患者可应用夜间氧疗(NOT)进行治疗,以避免可能的发病和死亡。 本研究的目的是在COPD患者中对6分钟步行试验(6MWT)和应用NOT期间的血氧饱和度下降之间的关系进行评估。 排除合并其他病症和呼吸衰竭的患者,本研究共纳入55例病情稳定的COPD患者,在这些患者中进行6MWT和夜间血氧饱和度测量。 分析显示,27例患者

发生夜间氧饱和度下降(NOD)的慢性阻塞性肺病(COPD)患者可应用夜间氧疗(NOT)进行治疗,以避免可能的发病和死亡。

本研究的目的是在COPD患者中对6分钟步行试验(6MWT)和应用NOT期间的血氧饱和度下降之间的关系进行评估。

排除合并其他病症和呼吸衰竭的患者,本研究共纳入55例病情稳定的COPD患者,在这些患者中进行6MWT和夜间血氧饱和度测量。

分析显示,27例患者患有中度COPD,28例患者患有重度COPD。在6MWT试验期间,3例中度COPD患者(11%)和12例重度COPD患者(42.9%)发生了血氧饱和度下降(P=0.003)。5例重度COPD患者(17.9%)发生了NOD,而在中度COPD患者中却无一例发生NOD。6MWT试验期间发生血氧饱和度下降的3例重度COPD患者(25%)也发生了NOD。NOD在重度COPD患者和二氧化碳水平较高的患者中较为常见(P值分别为0.02和0.001)。6MWT试验期间虽有3例中度COPD患者(11%)发生了饱和度降低,但这些患者却没有发生NOD。

虽然本次研究的样本量较小,其研究结果还缺乏说服力,但我们发现,NOD较常发生在6MWT期间出现血氧饱和度下降的COPD患者中,尤其是重度COPD患者。

【注:本研究于12月5日在线发表于《慢性呼吸病》(Chronic Respiratory Disease)杂志】

原始出处:

Iliaz S1, Cagatay T2, Bingol Z2, Okumus G2, Iliaz R3, Kuran G4, Kiyan E2, Cagatay P5.Does the 6-minute walk test predict nocturnal oxygen desaturation in patients with moderate to severe COPD?Chron Respir Dis. 2014 Dec 5. pii: 1479972314562406. [Epub ahead of print]


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    2015-05-18 yuanming15
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    2014-12-13 lqvr

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