Environ Health Perspect:空气污染可导致糖尿病发病风险

2015-01-30 MedSci MedSci原创

目前尚无流行病学证据和系统性评价来证明空气污染可能是是糖尿病的一个危险因素。 我们系统性回顾了空气污染与糖尿病之间有关的流行病学证据,并对2型糖尿病 (T2DM)的研究结果进行了综合性分析。 我们在电子文献数据库中搜索了与空气污染(颗粒浓度和交通污染)与糖尿病(1型,2型或者妊娠)之间有关的研究,时间截止到2014年4月29号。我们系统性评估了这些研究的偏倚带来的风险和其中潜在的混杂因

目前尚无流行病学证据和系统性评价来证明空气污染可能是是糖尿病的一个危险因素。

我们系统性回顾了空气污染与糖尿病之间有关的流行病学证据,并对2型糖尿病 (T2DM)的研究结果进行了综合性分析。

我们在电子文献数据库中搜索了与空气污染(颗粒浓度和交通污染)与糖尿病(1型,2型或者妊娠)之间有关的研究,时间截止到2014年4月29号。我们系统性评估了这些研究的偏倚带来的风险和其中潜在的混杂因素。在这项meta分析中,我们运用随机效应模型以及不同的敏感性分析总结出了与2型糖尿病有关的风险因素。

这项研究中我们收纳了来自在欧洲或北美的13项研究(8项T2DM,2项1型糖尿病,3项妊娠糖尿病)。在这13项研究中包括5个纵向研究,5个横断面研究,2个病例对照,1个生态学研究。偏移风险,空气污染评估和混杂因素贯穿整个研究。剂量-反应的影响没有被报道。在有关PM2.5(颗粒物直径< 2.5μm)的3项研究和有关NO2的4项研究中均表现出患2型糖尿病的风险每10μg / m3 增加8 - 10%[PM2.5: 1.10 (95% CI: 1.02, 1.18); NO2: 1.08 (95% CI: 1.00, 1.17)]. 这种联系在女性人群中更明显。在敏感性分析中也得到了相同的结果。

现有证据证明,空气污染是2型糖尿病发病风险的一个风险因素。高质量研究评估剂量-反应的影响也是必要的。在今后的研究中,研究数据也应该扩展到那些室内室外高污染的发展中国家。

原始出处

Eze IC1, Hemkens LG, Bucher HC, Hoffmann B, Schindler C, Künzli N, Schikowski T, Probst-Hensch NM.Association between Ambient Air Pollution and Diabetes Mellitus in Europe and North America: Systematic Review and Meta-Analysis.Environ Health Perspect. 2015 Jan 27

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    2015-02-23 anminleiryan
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    2015-02-28 feather89
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    2015-09-18 shizhenshan
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time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472459, encodeId=d04714e2459a1, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Sun Feb 01 02:52:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524187, encodeId=457f152418e00, content=<a href='/topic/show?id=053710045ad' target=_blank style='color:#2F92EE;'>#iron#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10045, encryptionId=053710045ad, topicName=iron)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1b11597510, createdName=july_979, createdTime=Sun Feb 01 02:52:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621521, encodeId=4ba7162152101, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Sun Feb 01 02:52:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14916, encodeId=c50114916c4, content=空气污染堪忧, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=139.227.156.**, createdTime=Sat Jan 31 09:10:00 CST 2015, time=2015-01-31, status=1, ipAttribution=)]
    2015-04-11 x35042875

    AKI对心衰临床治疗意义重大,但依然需要研究检验其适用性

    0

  5. 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time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472459, encodeId=d04714e2459a1, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Sun Feb 01 02:52:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524187, encodeId=457f152418e00, content=<a href='/topic/show?id=053710045ad' target=_blank style='color:#2F92EE;'>#iron#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10045, encryptionId=053710045ad, topicName=iron)], attachment=null, authenticateStatus=null, 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createdAvatar=null, createdBy=f0620, createdName=139.227.156.**, createdTime=Sat Jan 31 09:10:00 CST 2015, time=2015-01-31, status=1, ipAttribution=)]
    2015-03-27 xiaoai5777

    存上

    0

  6. 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time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472459, encodeId=d04714e2459a1, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Sun Feb 01 02:52:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524187, encodeId=457f152418e00, content=<a href='/topic/show?id=053710045ad' target=_blank style='color:#2F92EE;'>#iron#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10045, encryptionId=053710045ad, topicName=iron)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1b11597510, createdName=july_979, createdTime=Sun Feb 01 02:52:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621521, encodeId=4ba7162152101, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Sun Feb 01 02:52:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14916, encodeId=c50114916c4, content=空气污染堪忧, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=139.227.156.**, createdTime=Sat Jan 31 09:10:00 CST 2015, time=2015-01-31, status=1, ipAttribution=)]
    2015-02-17 chinayinhan

    已阅

    0

  7. 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time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472459, encodeId=d04714e2459a1, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Sun Feb 01 02:52:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524187, encodeId=457f152418e00, content=<a href='/topic/show?id=053710045ad' target=_blank style='color:#2F92EE;'>#iron#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10045, encryptionId=053710045ad, topicName=iron)], attachment=null, authenticateStatus=null, 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createdAvatar=null, createdBy=f0620, createdName=139.227.156.**, createdTime=Sat Jan 31 09:10:00 CST 2015, time=2015-01-31, status=1, ipAttribution=)]
  8. 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time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472459, encodeId=d04714e2459a1, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Sun Feb 01 02:52:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524187, encodeId=457f152418e00, content=<a href='/topic/show?id=053710045ad' target=_blank style='color:#2F92EE;'>#iron#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10045, encryptionId=053710045ad, topicName=iron)], attachment=null, authenticateStatus=null, 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createdAvatar=null, createdBy=f0620, createdName=139.227.156.**, createdTime=Sat Jan 31 09:10:00 CST 2015, time=2015-01-31, status=1, ipAttribution=)]
    2015-02-01 july_979
  9. 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    2015-01-31 139.227.156.**

    空气污染堪忧

    0

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