JAMA Dermatol:牛皮癣可能与糖尿病和肥胖发生相关

2016-04-30 MedSci MedSci原创

一项新的研究表明,慢性皮肤癣病可能与超重和2型糖尿病发病相关。丹麦的研究人员发现,与正常者相比,患有2型糖尿病者有牛皮癣的概率超过50%。研究还发现,牛皮癣发生率与体重上升有关。例如,身高体重指数(BMI)超过35的肥胖者患牛皮癣的概率比一般体重正常者高2倍。虽然这些条件是如何联系起来的尚不明确,但是研究人员相信,这与遗传、吸烟、酒精、炎症等因素有关。哥本哈根大学研究者Ann Sophie Lon


一项新的研究表明,慢性皮肤癣病可能与超重和2型糖尿病发病相关。

丹麦的研究人员发现,与正常者相比,患有2型糖尿病者有牛皮癣的概率超过50%。

研究还发现,牛皮癣发生率与体重上升有关。例如,身高体重指数(BMI)超过35的肥胖者患牛皮癣的概率比一般体重正常者高2倍。

虽然这些条件是如何联系起来的尚不明确,但是研究人员相信,这与遗传、吸烟、酒精、炎症等因素有关。

哥本哈根大学研究者Ann Sophie Lonnberg博士说道,“牛皮癣是一种复杂的疾病,该疾病的遗传背景尚未完全清晰。该研究不能证明牛皮癣能够导致2型糖尿病或肥胖,反之亦然,只能够表明牛皮癣与它们之间可能存在某种联系。牛皮癣与糖尿病或肥胖之间不仅通过生活方式相连接,可能也受相同基因的调控。积极治疗牛皮癣、糖尿病和肥胖是重要的,因为它们是心血管疾病的危险因素,威胁着人们健康。”

在这项研究中,Lonnberg和她的同事们共收集到近34000对双胞胎者,年龄另介于20到71岁间。他们中超过4%患有牛皮癣,略微超过1%者患有2型糖尿病,超过6%者肥胖。

在这460名2型糖尿病患者中,有约8%者患有牛皮癣。在没有患2型糖尿病者中,这一比例为4%。

牛皮癣患者体重比皮肤正常者有增高的趋势。肥胖在牛皮癣患者中发生率也比正常者高——11%的牛皮癣患者肥胖。

该研究结果发表在4月27日的JAMA皮肤科期刊网络版上。

牛皮癣不仅仅是单纯的皮肤病,其他研究表明,患有牛皮癣者更有可能发展为2型糖尿病。专家称,这可能是由于牛皮癣与糖尿病之间存在共享基因,此外,牛皮癣患者体内慢性炎症的发生也可能导致糖尿病。

研究者建议年龄在40岁以上的牛皮癣患者,应接受糖尿病筛查

原始出处:

Lønnberg AS, Skov L, Skytthe A, Kyvik KO, Pedersen OB, Thomsen SF. Association of Psoriasis With the Risk for Type 2 Diabetes Mellitus and Obesity. JAMA Dermatol. 2016 Apr 27. doi: 10.1001/jamadermatol.2015.6262

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2054972, encodeId=77dc20549e22a, content=<a href='/topic/show?id=4db9e66908b' target=_blank style='color:#2F92EE;'>#糖尿病和肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76690, encryptionId=4db9e66908b, topicName=糖尿病和肥胖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, createdName=12498cbcm00(暂无昵称), createdTime=Mon Jul 04 05:28:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85639, encodeId=3d378563931, content=学习了。在临床上确实有很多糖尿病人伴发牛皮癣的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160711/IMG578376C5E44359293.jpg, createdBy=f5131723986, createdName=WEIXIN876ebda9, createdTime=Fri May 13 09:42:00 CST 2016, time=2016-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85213, encodeId=3dfd852136c, content=原来这样呀学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=542c1722086, createdName=无卡啦, createdTime=Tue May 10 07:32:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83534, encodeId=bc648353476, content=赞同这个关点。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d231626576, createdName=jjzouyan, createdTime=Mon May 02 21:03:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321056, encodeId=4fc21321056e1, content=<a href='/topic/show?id=2a136e77095' target=_blank style='color:#2F92EE;'>#牛皮癣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67770, encryptionId=2a136e77095, topicName=牛皮癣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c2e485, createdName=yangfl06, createdTime=Mon May 02 11:28:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83479, encodeId=4693834e993, content=在真实世界研究中,能够发现大量以前认为不相关的疾病之间存在某种关联,这种关联可能背后有相似的,分子机制, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaELaQBNibpuZ0aRbWKgR0puf0vibBuZ7gIkKCXEqibYyJXVhsnibpCuhlqHGWRyvHMdFwm4UXjcpPUFLkw/0, createdBy=2f0f1714785, createdName=wxsession8b50a880, createdTime=Sun May 01 18:36:00 CST 2016, time=2016-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83455, encodeId=6f0f834552a, content=学习了,值得, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun May 01 16:23:00 CST 2016, time=2016-05-01, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2054972, encodeId=77dc20549e22a, content=<a href='/topic/show?id=4db9e66908b' target=_blank style='color:#2F92EE;'>#糖尿病和肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76690, encryptionId=4db9e66908b, topicName=糖尿病和肥胖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, createdName=12498cbcm00(暂无昵称), createdTime=Mon Jul 04 05:28:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85639, encodeId=3d378563931, content=学习了。在临床上确实有很多糖尿病人伴发牛皮癣的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160711/IMG578376C5E44359293.jpg, createdBy=f5131723986, createdName=WEIXIN876ebda9, createdTime=Fri May 13 09:42:00 CST 2016, time=2016-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85213, encodeId=3dfd852136c, content=原来这样呀学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=542c1722086, createdName=无卡啦, createdTime=Tue May 10 07:32:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83534, encodeId=bc648353476, content=赞同这个关点。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d231626576, createdName=jjzouyan, createdTime=Mon May 02 21:03:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321056, encodeId=4fc21321056e1, content=<a href='/topic/show?id=2a136e77095' target=_blank style='color:#2F92EE;'>#牛皮癣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67770, encryptionId=2a136e77095, topicName=牛皮癣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c2e485, createdName=yangfl06, createdTime=Mon May 02 11:28:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83479, encodeId=4693834e993, content=在真实世界研究中,能够发现大量以前认为不相关的疾病之间存在某种关联,这种关联可能背后有相似的,分子机制, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaELaQBNibpuZ0aRbWKgR0puf0vibBuZ7gIkKCXEqibYyJXVhsnibpCuhlqHGWRyvHMdFwm4UXjcpPUFLkw/0, createdBy=2f0f1714785, createdName=wxsession8b50a880, createdTime=Sun May 01 18:36:00 CST 2016, time=2016-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83455, encodeId=6f0f834552a, content=学习了,值得, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun May 01 16:23:00 CST 2016, time=2016-05-01, status=1, ipAttribution=)]
    2016-05-13 WEIXIN876ebda9

    学习了。在临床上确实有很多糖尿病人伴发牛皮癣的。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2054972, encodeId=77dc20549e22a, content=<a href='/topic/show?id=4db9e66908b' target=_blank style='color:#2F92EE;'>#糖尿病和肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76690, encryptionId=4db9e66908b, topicName=糖尿病和肥胖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, createdName=12498cbcm00(暂无昵称), createdTime=Mon Jul 04 05:28:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85639, encodeId=3d378563931, content=学习了。在临床上确实有很多糖尿病人伴发牛皮癣的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160711/IMG578376C5E44359293.jpg, createdBy=f5131723986, createdName=WEIXIN876ebda9, createdTime=Fri May 13 09:42:00 CST 2016, time=2016-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85213, encodeId=3dfd852136c, content=原来这样呀学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=542c1722086, createdName=无卡啦, createdTime=Tue May 10 07:32:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83534, encodeId=bc648353476, content=赞同这个关点。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d231626576, createdName=jjzouyan, createdTime=Mon May 02 21:03:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321056, encodeId=4fc21321056e1, content=<a href='/topic/show?id=2a136e77095' target=_blank style='color:#2F92EE;'>#牛皮癣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67770, encryptionId=2a136e77095, topicName=牛皮癣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c2e485, createdName=yangfl06, createdTime=Mon May 02 11:28:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83479, encodeId=4693834e993, content=在真实世界研究中,能够发现大量以前认为不相关的疾病之间存在某种关联,这种关联可能背后有相似的,分子机制, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaELaQBNibpuZ0aRbWKgR0puf0vibBuZ7gIkKCXEqibYyJXVhsnibpCuhlqHGWRyvHMdFwm4UXjcpPUFLkw/0, createdBy=2f0f1714785, createdName=wxsession8b50a880, createdTime=Sun May 01 18:36:00 CST 2016, time=2016-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83455, encodeId=6f0f834552a, content=学习了,值得, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun May 01 16:23:00 CST 2016, time=2016-05-01, status=1, ipAttribution=)]
    2016-05-10 无卡啦

    原来这样呀学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2054972, encodeId=77dc20549e22a, content=<a href='/topic/show?id=4db9e66908b' target=_blank style='color:#2F92EE;'>#糖尿病和肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76690, encryptionId=4db9e66908b, topicName=糖尿病和肥胖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, createdName=12498cbcm00(暂无昵称), createdTime=Mon Jul 04 05:28:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85639, encodeId=3d378563931, content=学习了。在临床上确实有很多糖尿病人伴发牛皮癣的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160711/IMG578376C5E44359293.jpg, createdBy=f5131723986, createdName=WEIXIN876ebda9, createdTime=Fri May 13 09:42:00 CST 2016, time=2016-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85213, encodeId=3dfd852136c, content=原来这样呀学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=542c1722086, createdName=无卡啦, createdTime=Tue May 10 07:32:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83534, encodeId=bc648353476, content=赞同这个关点。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d231626576, createdName=jjzouyan, createdTime=Mon May 02 21:03:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321056, encodeId=4fc21321056e1, content=<a href='/topic/show?id=2a136e77095' target=_blank style='color:#2F92EE;'>#牛皮癣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67770, encryptionId=2a136e77095, topicName=牛皮癣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c2e485, createdName=yangfl06, createdTime=Mon May 02 11:28:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83479, encodeId=4693834e993, content=在真实世界研究中,能够发现大量以前认为不相关的疾病之间存在某种关联,这种关联可能背后有相似的,分子机制, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaELaQBNibpuZ0aRbWKgR0puf0vibBuZ7gIkKCXEqibYyJXVhsnibpCuhlqHGWRyvHMdFwm4UXjcpPUFLkw/0, createdBy=2f0f1714785, createdName=wxsession8b50a880, createdTime=Sun May 01 18:36:00 CST 2016, time=2016-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83455, encodeId=6f0f834552a, content=学习了,值得, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun May 01 16:23:00 CST 2016, time=2016-05-01, status=1, ipAttribution=)]
    2016-05-02 jjzouyan

    赞同这个关点。

    0

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    2016-05-01 wxsession8b50a880

    在真实世界研究中,能够发现大量以前认为不相关的疾病之间存在某种关联,这种关联可能背后有相似的,分子机制

    0

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    2016-05-01 dhzzm

    学习了,值得

    0

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