BMC Anesthesiol:脑氧饱和度或可提示全膝置换术后的认知下降

2014-11-19 少年春衫薄 丁香园

全麻手术后,患者常有不同类型的认知缺损,如记忆下降、执行功能改变。非侵入性记录双侧局部脑氧饱和度(regional cerebral oxygen saturation,rSO2),可监测手术中氧气水平和脑血流动力,反映脑的功能状态。一些研究认为rSO2与腹部、心脏手术后的认知功能障碍显著相关,但最近一项meta分析显示证据并不支持。 近期BMC Anesthesiology刊登了一则事后分析研

全麻手术后,患者常有不同类型的认知缺损,如记忆下降、执行功能改变。非侵入性记录双侧局部脑氧饱和度(regional cerebral oxygen saturation,rSO2),可监测手术中氧气水平和脑血流动力,反映脑的功能状态。一些研究认为rSO2与腹部、心脏手术后的认知功能障碍显著相关,但最近一项meta分析显示证据并不支持。

近期BMC Anesthesiology刊登了一则事后分析研究,旨在探讨采用rSO2作为大型非心脏手术后不同类型的心理功能下降的预警价值。

该研究纳入了125名年逾65岁的患者,均有脊髓麻醉下全膝置换术史;对照组为55名未经手术治疗的患者。研究测量了受试者基线及术后3个月的rSO2,以绝对值<50%或下降>20%或低于基线>25%为截断点。此外还评价了视觉-运动协调性和执行功能(韦氏成人智力量表第三版中的数字符号-编码和视觉复制测验、连线测验)、记忆能力(听觉词语学习测验、韦氏记忆量表)。

结果显示,两组受试者之间的基线rSO2值无差异。手术组全部患者术中rSO2下降(P < 0.0001),60%患者未出现认知下降或心理症状,16.8%患者记忆下降,2.4%患者视运动协调和执行功能下降,26.4%患者有心理症状。

与无记忆下降症状的患者相比,记忆下降患者的左-右侧rSO2值不对称(左/右比率95.03±8.51)(P = 0.0012);右-左侧rSO2的差异亦显著(-2.87%±4.73%),右侧更低(P = 0.0034)。这种术中rSO2值不对称的趋势,可以作为术后记忆下降的预警信号。

原始出处

Salazar F1, Doñate M2, Boget T2, Bogdanovich A1, Basora M1, Torres F3, Gracia I1, Fàbregas N1.Relationship Between Intraoperative Regional Cerebral Oxygen Saturation Trends and Cognitive Decline After Total Knee Replacement.BMC Anesthesiol. 2014 Jul 21

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    2015-01-10 yxch48
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    2015-10-14 xiangyuzhou971
  5. [GetPortalCommentsPageByObjectIdResponse(id=2028584, encodeId=9dd72028584db, content=<a href='/topic/show?id=bc58912088f' target=_blank style='color:#2F92EE;'>#认知下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91208, encryptionId=bc58912088f, topicName=认知下降)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Sep 23 04:37:00 CST 2015, time=2015-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742314, encodeId=a3301e423140a, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Sat Jan 10 18:37:00 CST 2015, time=2015-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974582, encodeId=007f19e4582d1, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sun Jan 11 11:37:00 CST 2015, time=2015-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050421, encodeId=7469205042194, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Oct 14 19:37:00 CST 2015, time=2015-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576497, encodeId=846215e6497c1, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Fri Nov 21 02:37:00 CST 2014, time=2014-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588170, encodeId=901e15881e04a, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Fri Nov 21 02:37:00 CST 2014, time=2014-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595728, encodeId=26601595e280e, content=<a href='/topic/show?id=c5326402609' target=_blank style='color:#2F92EE;'>#氧饱和度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64026, encryptionId=c5326402609, topicName=氧饱和度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2d218300656, createdName=lqvr, createdTime=Fri Nov 21 02:37:00 CST 2014, time=2014-11-21, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2028584, encodeId=9dd72028584db, content=<a href='/topic/show?id=bc58912088f' target=_blank style='color:#2F92EE;'>#认知下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91208, encryptionId=bc58912088f, topicName=认知下降)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Sep 23 04:37:00 CST 2015, time=2015-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742314, encodeId=a3301e423140a, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Sat Jan 10 18:37:00 CST 2015, time=2015-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974582, encodeId=007f19e4582d1, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sun Jan 11 11:37:00 CST 2015, time=2015-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050421, encodeId=7469205042194, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Oct 14 19:37:00 CST 2015, time=2015-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576497, encodeId=846215e6497c1, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Fri Nov 21 02:37:00 CST 2014, time=2014-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588170, encodeId=901e15881e04a, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Fri Nov 21 02:37:00 CST 2014, time=2014-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595728, encodeId=26601595e280e, content=<a href='/topic/show?id=c5326402609' target=_blank style='color:#2F92EE;'>#氧饱和度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64026, encryptionId=c5326402609, topicName=氧饱和度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2d218300656, createdName=lqvr, createdTime=Fri Nov 21 02:37:00 CST 2014, time=2014-11-21, status=1, ipAttribution=)]
    2014-11-21 skhzy
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    2014-11-21 lqvr

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