Nat Genet：科学家发现老年痴呆症相关基因变异

据《自然—遗传学》Nature Genetics上的一项研究显示，科学家们找到了阿尔茨海默氏症（俗称老年痴呆症）的多个遗传变异。【原文下载】

Philippe Amouyel等人开展了一项大范围关联分析，对17008名老年痴呆症患者进行全基因组关联研究，并选取37154名健康个体作为对照组，之后再对另外8572名患者进行了第二阶段研究，选取11312名健康个体作为对照组。除了之前已发现的APOE基因组的关联外，他们发现了19个对晚发型老年痴呆症具有重要影响的基因组区域，其中11个属于易感性基因座。

Amouyel的这项发现印证了之前老年痴呆症病理学涉及到的几个途径，包括免疫反应、炎症、细胞迁移和类脂运输通路。

此外，研究人员还提出了一些可能对患病风险有影响的其他基因和通路。

原文出处

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