Diabetes Care:1型糖尿病患者发生卒中后的预后及其预测指标!

2017-08-16 xing.T MedSci原创

由此可见,1型糖尿病伴卒中的患者心血管预后不良,并且全因死亡风险较高。尤其是出血性卒中亚型和糖尿病肾病进展的患者中出现了更坏的结局。

尽管1型糖尿病患者卒中后预后不佳,但对这些患者卒中后存活的预测研究甚少。近日,糖尿病领域权威杂志Diabetes Care上发表了一项观察性研究的研究结果。

在这项观察性研究中,4083例1型糖尿病患者共计有144例患者发生卒中,这些参与者来自于1997年-2010年的芬兰糖尿病肾病研究,并在卒中之后平均随访3.4±3.1年。信息记录了由于心血管或与糖尿病有关的原因引起的心血管事件和死亡,统称为血管复合终点。研究人员从医疗记录、死亡证明和国家保健登记中心收集信息。该研究的终点事件为卒中发生的预测因子。

在随访期间,104例(72%)患者发生了血管复合终点。其中33例(32%)患者出现复发性卒中,33例(32%)患者为心血管事件,76例(53%)患者死于心血管或糖尿病相关疾病,1年总生存率为76%,5年生存率为58%。血管复合终点的预测因子包括出血性卒中亚型(风险比为2.03(95%CI为1.29-3.19))、以及慢性肾脏病2期(2.48,1.17-5.24)、3期(3.04,1.54-6.04)、4期(3.95,1.72-9.04)和5期(6.71,3.14-14.34)。全因死亡率随着肾功能恶化而有所增加。

由此可见,1型糖尿病伴卒中的患者心血管预后不良,并且全因死亡风险较高。尤其是出血性卒中亚型和糖尿病肾病进展的患者中出现了更坏的结局。

原始出处:

Stefanie Hägg-Holmberg,et al. Prognosis and Its Predictors After Incident Stroke in Patients With Type 1 Diabetes.Diabetes Care 2017 Aug. https://doi.org/10.2337/dc17-0681

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    2017-08-17 往日如昨

    学习了谢谢分享

    0

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    2017-08-16 changjiu

    学习了,谢谢

    0

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这项研究首次显示血浆MGO水平与1型糖尿病患者的心血管事件相关。MGO至少可以部分解释1型糖尿病患者心血管疾病的风险增加的原因。

JCEM:小剂量胰高血糖素治疗1型糖尿病患者非严重低血糖症的疗效和安全性如何?

低剂量胰高血糖素可以成功地治疗轻度至中度低血糖,并可能是口服碳水化合物的一种有用的替代治疗,尽量避免了不必要的热量摄入。