Int Heart J:牙周炎可加重马方综合征患者的主动脉窦扩张程度

2016-07-10 MedSci MedSci原创

马凡氏综合征(Marfan syndrome,MFS)为一种遗传性全身结缔组织疾病,为fibrillin-1突变所导致。虽然MFS患者牙周炎和主动脉疾病的发生风险很高,但是目前为止还未有研究明确表明这些疾病是否存在因果关系。为了探究并明确这些疾病之间的关联,本研究评估了MFS患者的口腔状况和主动脉窦(SoV)。研究共纳入了就诊于东京大学医院的33名MFS患者。将其分为两组;MFS患者伴有高度扩张(

马方综合征(Marfan syndrome,MFS)为一种遗传性全身结缔组织疾病,为fibrillin-1突变所导致。虽然MFS患者牙周炎和主动脉疾病的发生风险很高,但是目前为止还未有研究明确表明这些疾病是否存在因果关系。为了探究并明确这些疾病之间的关联,本研究评估了MFS患者的口腔状况和主动脉窦(SoV)。

研究共纳入了就诊于东京大学医院的33名MFS患者。将其分为两组;MFS患者伴有高度扩张(直径≥39毫米)SoV组(高度扩张组,n =18)和MFS患者伴有轻度扩张(<39毫米)SoV组(轻度扩张组,n = 15)。对所有参与者进行血液检查、超声心动图、及全口临床评估,包括牙齿数目、牙周袋深度(PPD),探诊出血(BOP),和社区牙周指数(CPI)。

结果发现,与轻度扩张组患者相比,高度扩张组患者的BOP率更高。此外,高度扩张组患者的血清C-反应蛋白、基质金属蛋白酶-9、及转化生长因子-β的水平通常越高。

总而言之,该研究发现牙周炎可能会恶化MFS患者的SOV扩张程度。

原始出处:

Suzuki JI, Imai Y, Aoki M et al., Periodontitis May Deteriorate Sinus of Valsalva Dilatation in Marfan Syndrome Patients. Int Heart J. 2016 Jul 7.


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    2017-04-02 lsj637
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    2016-10-12 1e0ece0dm09(暂无匿称)

    谢谢分享学习

    0

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    2016-10-11 1e10c84am36(暂无匿称)

    好文章,受益

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Sep 12 19:08:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=123394, encodeId=7ec812339430, content=文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Sep 12 10:44:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356084, encodeId=65df13560849d, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, 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encodeId=4f0a1430640d6, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Jul 12 04:32:00 CST 2016, time=2016-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450477, encodeId=8f4814504e799, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Jul 12 04:32:00 CST 2016, time=2016-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562374, encodeId=497e15623e482, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Jul 12 04:32:00 CST 2016, time=2016-07-12, status=1, ipAttribution=)]
    2016-09-12 ylzr123

    赞了!深度好文,拜读,深入学习。

    0

  5. 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authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Jul 12 04:32:00 CST 2016, time=2016-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562374, encodeId=497e15623e482, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Jul 12 04:32:00 CST 2016, time=2016-07-12, status=1, ipAttribution=)]
    2016-09-12 1e10c84am36(暂无匿称)

    文章不错

    0

  6. 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authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Jul 12 04:32:00 CST 2016, time=2016-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562374, encodeId=497e15623e482, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Jul 12 04:32:00 CST 2016, time=2016-07-12, status=1, ipAttribution=)]
    2016-07-12 zhaojie88
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    2016-07-12 slcumt

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