Neuropsychopharmacology:大麻衍生物有助于治疗精神病

2017-06-05 tulip1999 来宝网

一项最新研究通过检测大麻化合物对大鼠的影响,为开发精神分裂症新疗法铺平了道路。这项研究表明,大麻衍生物可能会改善精神分裂症特异性认知功能障碍,且没有目前其他药物具有的任何副作用。

一项最新研究通过检测大麻化合物对大鼠的影响,为开发精神分裂症新疗法铺平了道路。这项研究表明,大麻衍生物可能会改善精神分裂症特异性认知功能障碍,且没有目前其他药物具有的任何副作用.

大约有1.1%美国人口(约350万成人)罹患精神分裂症。

虽然目前的抗精神病药物能够有效地治疗其阳性症状——如幻觉和妄想——但对于其认知功能和阴性症状则不太有效。

此外,抗精神病药物还可引起广泛的副作用,包括肌肉痉挛、烦躁不安、震颤以及嗜睡或头晕。一些不常用的处方药会导致体重增加、代谢发生改变、糖尿病风险增加以及胆固醇水平升高。

这就是为什么该项新研究着眼于潜在的大麻化合物——被称为大麻二醇(CBD)——能否用于治疗精神分裂症的更多疑难症状。

发表在《 Neuropsychopharmacology》杂志上的这项最新研究是由来自澳大利亚新南威尔士澳大利亚健康与医学研究所(IHMRI)的一个研究小组完成的。

来自澳大利亚卧龙岗大学的Katrina Green博士领导的研究人员在进行了27项研究的综述研究之后,首次发现了大麻二醇(CBD)的治疗价值。

“证据显示,大麻二醇(CBD)具有神经保护作用,可降低认知功能损害,大麻二醇(CBD)的作用与δ-9-四氢大麻酚(THC)的使用有关,后者是大麻中主要的抗精神病成分,”Green博士说道。

研究人员发出警告,不要将大麻及其衍生物产品用于治疗精神分裂症,因为δ-9-四氢大麻酚(THC)可能会使精神分裂症症状恶化。

原始出处:

Osborne AL, Solowij N, et al. Improved Social Interaction, Recognition and Working Memory with Cannabidiol Treatment in a Prenatal Infection (poly I:C) Rat Model. Neuropsychopharmacology. 2017 Jun;42(7):1447-1457. doi: 10.1038/npp.2017.40.

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encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Wed Jun 07 13:15:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207414, encodeId=f5b820e414eb, content=继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCcmyvDOwDu2ZpuYyovmsD12IBHmUCwr5bZqNic2p50ogCxUAIj4YqJ3PsGwoXOhJPQAvicmu6RqOww/0, createdBy=a0bf1958339, createdName=七九九八, createdTime=Tue Jun 06 21:32:09 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-10-17 jj000001
  5. 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    2017-11-24 yb6560
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  7. 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encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Wed Jun 07 13:15:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207414, encodeId=f5b820e414eb, content=继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCcmyvDOwDu2ZpuYyovmsD12IBHmUCwr5bZqNic2p50ogCxUAIj4YqJ3PsGwoXOhJPQAvicmu6RqOww/0, createdBy=a0bf1958339, createdName=七九九八, createdTime=Tue Jun 06 21:32:09 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-10 kane35

    单方药物有时会捉襟见肘,呼唤中医。

    0

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encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Wed Jun 07 13:15:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207414, encodeId=f5b820e414eb, content=继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCcmyvDOwDu2ZpuYyovmsD12IBHmUCwr5bZqNic2p50ogCxUAIj4YqJ3PsGwoXOhJPQAvicmu6RqOww/0, createdBy=a0bf1958339, createdName=七九九八, createdTime=Tue Jun 06 21:32:09 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-07 kcb069
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encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Wed Jun 07 13:15:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207414, encodeId=f5b820e414eb, content=继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCcmyvDOwDu2ZpuYyovmsD12IBHmUCwr5bZqNic2p50ogCxUAIj4YqJ3PsGwoXOhJPQAvicmu6RqOww/0, createdBy=a0bf1958339, createdName=七九九八, createdTime=Tue Jun 06 21:32:09 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-06 七九九八

    继续努力

    0