Sci Rep:原位肾细胞癌异种移植模型实验成像比较分析

2017-10-30 AlexYang MedSci原创

最近,有研究人员在原位肾细胞癌(RCC)异种种植模型中比较性的评估了高分辨率3D超声波扫描成像(hrUS)、体内显微CT(μCT)和9.4TMRI技术对肿瘤生长的监控情况,并且目前还没有一种确定的和非侵入性的成像工具来实现上述目的。研究人员将1×106 Caki-2 RCC细胞移植到16只免疫缺陷小鼠的肾包膜上,并利用hrUS、μCT和MRI检查对局部的和全身的肿瘤生长进行监控。细胞移植到了所有的

最近,有研究人员在原位肾细胞癌(RCC)异种种植模型中比较性的评估了高分辨率3D超声波扫描成像(hrUS)、体内显微CT(μCT)和9.4TMRI技术对肿瘤生长的监控情况,并且目前还没有一种确定的和非侵入性的成像工具来实现上述目的。

研究人员将1×106 Caki-2 RCC细胞移植到16只免疫缺陷小鼠的肾包膜上,并利用hrUS、μCT和MRI检查对局部的和全身的肿瘤生长进行监控。细胞移植到了所有的小鼠中并且导致了实体瘤的指数增长。另外,研究人员利用所有的成像技术来检测原位肿瘤并且精确的计算了这些肿瘤的体积。虽然在μCT中,肿瘤表现出同质的且射线可透过的,hrUS和MRI表现出了肿瘤内部结构和周围软组织更高的可视化效果。hrUS的检测时间最短,其次是μCT和MIR。通过hrUS、μCT和MRI技术计算的肿瘤体积相互之间以及与尸检测量之间具有很好的相关性。10种动物发展成为的肺转移癌可以用μCT和MIR很好的检测。

最后,研究人员指出,每种技术都有其独特的优势和劣势,因此对一个特定的实验,个性化的选择也许是最好的。

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    2017-10-31 三生有幸9135

    学习一下谢谢分享

    0

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    2017-10-30 doctorJiangchao

    谢谢分享.

    0

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    2017-10-30 doctorJiangchao

    继续关注.

    0

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    2017-10-30 doctorJiangchao

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