Gut:ω-3多不饱和脂肪酸与肠道微生物菌群

2017-09-27 zhangfan MedSci原创

ω-3多不饱和脂肪酸可以引起几种短链脂肪酸产生菌丰度增加,肠道微生物系统与ω-3多不饱和脂肪酸之间的关系远比之前理解的复杂

研究证实ω-3多不饱和脂肪酸(PUFA)具有抗结肠癌的作用,而结肠癌发病与肠道菌群有关。小鼠模型研究证实饮食中ω-3多不饱和脂肪酸可改变小鼠肠道微生物组成,同时兼具抗肿瘤活性。近日研究人员考察了ω-3多不饱和脂肪酸补充对中老年健康志愿者粪便的微生物的影响。

研究招募了22名志愿者,进行为期8周的二十碳五烯酸/二十二碳六烯酸补充,每天4g。试验完成后经过12周间隔后在5个时间点采集粪便样品进行16S核糖体RNA的PCR微生物分析和Illumina Miseq测序,采用液相色谱-串联质谱法进行红细胞(RBC)-脂肪酸分析。

研究发现2种PUFA对红细胞脂肪酸含量的影响相近。ω-3多不饱和脂肪酸补充未显著影响大多数肠道菌群的多样性以及种群丰度,但显著提高了双歧杆菌、罗斯伯里氏菌和乳酸杆菌的丰度。肠道菌群的变化对红细胞与多不饱和脂肪酸的结合或ω-3多不饱和脂肪酸引起的腹泻无显著相关性。

ω-3多不饱和脂肪酸可以引起几种短链脂肪酸产生菌丰度增加,肠道微生物系统与ω-3多不饱和脂肪酸之间的关系远比之前理解的复杂。

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    2017-09-27 天涯183

    非常好的文章.学习了

    0

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Oncogene:新研究为结肠癌患者提供新的治疗策略

结肠直肠癌是全球第四大癌症致死的相关原因。

Gastroenterology:大锯齿状息肉对异时大锯齿状息肉和高危腺瘤风险的影响

研究认为,大锯齿状息肉增加患者异时锯齿状息肉风险,但不影响患者的异时高危腺瘤风险;高危腺瘤并发锯齿状息肉显著提高患者异时高危腺瘤风险。对于高危腺瘤患者应加强对疾病的监控,预防癌变恶化

Redox Biol:铁蔗糖和抗坏血酸药物联合使用或有助于结肠癌的治疗!

研究提示,抗坏血酸药物(如维生素C)在静脉注射安全剂量范围内能够通过一种依赖于H2O2生成的机制有选择地杀死癌细胞,其形成H2O2的过程被认为是由氧化还原活性金属离子如铁(Fe)催化介导的。

J NUTR BIOCHEM:对抗结肠癌和慢性结肠炎症,你可能需要吃“素”了

一项由多国科学家参与的研究发现,由大量“彩色”果蔬构成的饮食中可能含有能够对抗结肠癌和炎症性肠道疾病的化合物。这一结论来自在小猪身上的试验,研究者认为了解这些化合物的分子机制是发现某些癌症新疗法的第一步。这项研究在认识这一因果关系上迈出了一步。富含人体所需营养素(如蛋白质)的饮食,以及富含植物营养素(如维生素、类胡萝卜素和黄酮类化合物)的饮食,可以有效地改变猪体内结肠粘膜细胞白介素-6(IL-6)