Gastroenterology Report:炎症性肠病患者患结直肠肿瘤的危险因素分析

2019-05-24 不详 MedSci原创

炎症性肠病患者长期带病生存后有患结直肠肿瘤的风险,本研究旨在评估中国炎症性肠病(IBD)患者结肠炎相关瘤形成(CAN)发生的危险因素。

背景
炎症性肠病患者长期带病生存后有患结直肠肿瘤的风险,本研究旨在评估中国炎症性肠病(IBD)患者结肠炎相关瘤形成(CAN)发生的危险因素。

方法
研究人员从八个三级转诊中心纳入了1999年至2016年间发生CAN的IBD患者。研究人员对性别和IBD类型按照三个对照与一个受试者的比率进行匹配,最终将CAN患者(n= 29)与非CAN对照组(n= 87)进行分析比较。

结果
在29例CAN患者中,8例(27.6%)患有直肠癌(CRC),20例(69.0%)最终诊断为低度不典型增生,1例(3.4%)患有高度不典型增生。多变量分析显示,IBD诊断时年龄较大且IBD持续时间较长是CAN发展的独立危险因素,优势比为1.09 [95%置信区间(CI):1.04-1.14,P< 0.001]和1.14(95%CI:1.03-1.27,P = 0.013)。患有CRC的IBD患者和发育不良患者之间的比较表明,前者在IBD诊断时年龄较大(P= 0.012)并且具有较长的IBD持续时间(P = 0.019)。

结论
IBD诊断时的年龄较大且IBD持续时间较长被发现与IBD患者的CAN发展有关。

原始出处:

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    2019-12-02 许安
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