感染

订阅

MedSci主页 / 所有栏目 / 感染

J Nat Prod：对柯萨奇B3病毒CVB3和人鼻病毒HRV1B有抑制作用的木脂素类化合物

2019-01-30 碳硼酸 病毒学界

木脂素柯萨奇病毒人鼻病毒
关注

近日，韩国首尔大学学者从一种连翘属植物金钟花Forsythia viridissima的根中分离得到了15个木脂素类化合物，并报道了它们对柯萨奇B3病毒CVB3和人鼻病毒HRV1B的抑制作用。

导 读

连翘(木犀科)是东亚的一种观赏植物，其干果(韩语：Yeon-kyo)因其具有的抗炎、解热、利尿和抗菌作用而被用作传统草药。前期研究结果表明，连翘的次级代谢产物极其丰富，其中二苄基丁内酯型木脂素（比如有名的马台树脂醇和牛蒡子苷）是其主要成分。近日，韩国首尔大学学者从一种连翘属植物金钟花Forsythia viridissima的根中分离得到了15个木脂素类化合物，并报道了它们对柯萨奇B3病毒CVB3和人鼻病毒HRV1B的抑制作用。相关研究发表于Journal of Natural Products，题为“Lignan Dimers from Forsythia viridissima Roots and Their Antiviral Effects”。

结果速览

从金钟花(Forsythia Viridissima)根中分离到6个新的二聚木脂素(1-6)和1个新的木脂素苷(16)，以及9个已知的木脂素(7-15)。采用光谱分析和化学方法确定这些化合物的结构和它们的绝对结构。在这些化合物中，dimatairesinol(1)和viridissimaols A？E(2-6)是二苄基丁内酯类似物的二聚体。此外，对化合物抗柯萨奇病毒B3(CVB3)和人鼻病毒1B(HRV1B)的抗病毒活性进行了评价。试验结果表明，化合物12和15显示出抗CVB3活性，IC50分别为15.4和36.4μM；而2、3、8和9对HRV1B有抑制作用，IC50分别为45.7、47.5、13.0和43.2μM。

新化合物1-6和16的结构如下图所示：

已知化合物7-15结构如下图所示：

化合物4（1.1mg）和5（1.1mg）由于分得的量较少，没有测试其活性。以芦平曲韦作阳性对照，测试了化合物1-3和6-16的抗病毒活性。化合物12和15具有抗CVB3活性，IC50分别为15.4和36.4μM；化合物2、3、8和9具有抗HRV1B活性，IC50分别为45.7、47.5、13.0和43.2μM。

化合物12和15在50μM时对Vero细胞无细胞毒作用，能逆转严重感染CVB3的Vero细胞的病变形态。此外，化合物2，3，8和9减少了HRV1B感染的HeLa细胞中可见细胞病变的形成，且没有细胞毒性。

因此，二聚木脂素和其他木脂素类化合物可能有助于治疗某些病毒感染。

原始出处：Huh J, Song JH, Kim SR, et al. Lignan Dimers from Forsythia viridissima Roots and Their Antiviral Effects. J Nat Prod. 2019 Jan 24.

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1635452, encodeId=1cce163545244, content=<a href='/topic/show?id=b099549160a' target=_blank style='color:#2F92EE;'>#抑制作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54916, encryptionId=b099549160a, topicName=抑制作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6cd322475383, createdName=124987a0m73(暂无昵称), createdTime=Sun Dec 29 18:49:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906406, encodeId=d18e1906406f4, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sun May 26 08:49:00 CST 2019, time=2019-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1883561, encodeId=979718835616b, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Apr 20 07:49:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359993, encodeId=af563599938a, content=不错的作品，为我们探讨研究提供了方针，必须给点个赞了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Feb 05 14:09:36 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602111, encodeId=6c491602111f9, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Feb 01 04:49:00 CST 2019, time=2019-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626595, encodeId=95a9162659517, content=<a href='/topic/show?id=6a3b10348172' target=_blank style='color:#2F92EE;'>#鼻病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103481, encryptionId=6a3b10348172, topicName=鼻病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e59021047417, createdName=tonychen28, createdTime=Fri Feb 01 04:49:00 CST 2019, time=2019-02-01, status=1, ipAttribution=)]
    2019-12-29 124987a0m73(暂无昵称)

    #抑制作用#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1635452, encodeId=1cce163545244, content=<a href='/topic/show?id=b099549160a' target=_blank style='color:#2F92EE;'>#抑制作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54916, encryptionId=b099549160a, topicName=抑制作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6cd322475383, createdName=124987a0m73(暂无昵称), createdTime=Sun Dec 29 18:49:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906406, encodeId=d18e1906406f4, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sun May 26 08:49:00 CST 2019, time=2019-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1883561, encodeId=979718835616b, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Apr 20 07:49:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359993, encodeId=af563599938a, content=不错的作品，为我们探讨研究提供了方针，必须给点个赞了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Feb 05 14:09:36 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602111, encodeId=6c491602111f9, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Feb 01 04:49:00 CST 2019, time=2019-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626595, encodeId=95a9162659517, content=<a href='/topic/show?id=6a3b10348172' target=_blank style='color:#2F92EE;'>#鼻病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103481, encryptionId=6a3b10348172, topicName=鼻病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e59021047417, createdName=tonychen28, createdTime=Fri Feb 01 04:49:00 CST 2019, time=2019-02-01, status=1, ipAttribution=)]
    2019-05-26 wangyang7958

    #化合物#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1635452, encodeId=1cce163545244, content=<a href='/topic/show?id=b099549160a' target=_blank style='color:#2F92EE;'>#抑制作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54916, encryptionId=b099549160a, topicName=抑制作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6cd322475383, createdName=124987a0m73(暂无昵称), createdTime=Sun Dec 29 18:49:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906406, encodeId=d18e1906406f4, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sun May 26 08:49:00 CST 2019, time=2019-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1883561, encodeId=979718835616b, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Apr 20 07:49:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359993, encodeId=af563599938a, content=不错的作品，为我们探讨研究提供了方针，必须给点个赞了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Feb 05 14:09:36 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602111, encodeId=6c491602111f9, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Feb 01 04:49:00 CST 2019, time=2019-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626595, encodeId=95a9162659517, content=<a href='/topic/show?id=6a3b10348172' target=_blank style='color:#2F92EE;'>#鼻病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103481, encryptionId=6a3b10348172, topicName=鼻病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e59021047417, createdName=tonychen28, createdTime=Fri Feb 01 04:49:00 CST 2019, time=2019-02-01, status=1, ipAttribution=)]
    2019-04-20 liye789132251

    #Nat#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1635452, encodeId=1cce163545244, content=<a href='/topic/show?id=b099549160a' target=_blank style='color:#2F92EE;'>#抑制作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54916, encryptionId=b099549160a, topicName=抑制作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6cd322475383, createdName=124987a0m73(暂无昵称), createdTime=Sun Dec 29 18:49:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906406, encodeId=d18e1906406f4, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sun May 26 08:49:00 CST 2019, time=2019-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1883561, encodeId=979718835616b, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Apr 20 07:49:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359993, encodeId=af563599938a, content=不错的作品，为我们探讨研究提供了方针，必须给点个赞了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Feb 05 14:09:36 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602111, encodeId=6c491602111f9, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Feb 01 04:49:00 CST 2019, time=2019-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626595, encodeId=95a9162659517, content=<a href='/topic/show?id=6a3b10348172' target=_blank style='color:#2F92EE;'>#鼻病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103481, encryptionId=6a3b10348172, topicName=鼻病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e59021047417, createdName=tonychen28, createdTime=Fri Feb 01 04:49:00 CST 2019, time=2019-02-01, status=1, ipAttribution=)]
    2019-02-05 lietome24

    不错的作品，为我们探讨研究提供了方针，必须给点个赞了！

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1635452, encodeId=1cce163545244, content=<a href='/topic/show?id=b099549160a' target=_blank style='color:#2F92EE;'>#抑制作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54916, encryptionId=b099549160a, topicName=抑制作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6cd322475383, createdName=124987a0m73(暂无昵称), createdTime=Sun Dec 29 18:49:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906406, encodeId=d18e1906406f4, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sun May 26 08:49:00 CST 2019, time=2019-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1883561, encodeId=979718835616b, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Apr 20 07:49:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359993, encodeId=af563599938a, content=不错的作品，为我们探讨研究提供了方针，必须给点个赞了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Feb 05 14:09:36 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602111, encodeId=6c491602111f9, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Feb 01 04:49:00 CST 2019, time=2019-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626595, encodeId=95a9162659517, content=<a href='/topic/show?id=6a3b10348172' target=_blank style='color:#2F92EE;'>#鼻病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103481, encryptionId=6a3b10348172, topicName=鼻病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e59021047417, createdName=tonychen28, createdTime=Fri Feb 01 04:49:00 CST 2019, time=2019-02-01, status=1, ipAttribution=)]
    2019-02-01 sunylz

    #PRO#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1635452, encodeId=1cce163545244, content=<a href='/topic/show?id=b099549160a' target=_blank style='color:#2F92EE;'>#抑制作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54916, encryptionId=b099549160a, topicName=抑制作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6cd322475383, createdName=124987a0m73(暂无昵称), createdTime=Sun Dec 29 18:49:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906406, encodeId=d18e1906406f4, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sun May 26 08:49:00 CST 2019, time=2019-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1883561, encodeId=979718835616b, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Apr 20 07:49:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359993, encodeId=af563599938a, content=不错的作品，为我们探讨研究提供了方针，必须给点个赞了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Feb 05 14:09:36 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602111, encodeId=6c491602111f9, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Feb 01 04:49:00 CST 2019, time=2019-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626595, encodeId=95a9162659517, content=<a href='/topic/show?id=6a3b10348172' target=_blank style='color:#2F92EE;'>#鼻病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103481, encryptionId=6a3b10348172, topicName=鼻病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e59021047417, createdName=tonychen28, createdTime=Fri Feb 01 04:49:00 CST 2019, time=2019-02-01, status=1, ipAttribution=)]
    2019-02-01 tonychen28

    #鼻病毒#

    0