Circ Heart Fai:心衰增加了肾功能正常者的肾脏不良结局风险

2017-08-06 fengxiangxin MedSci原创

心力衰竭(HF)与心脏不良结局和死亡率相关。但尚没有研究证据表明HF与肾功能正常者的肾脏不良结局有联系。研究者事先假设心衰与长期肾脏结局较差相关。

心力衰竭(HF)与心脏不良结局和死亡率相关。但尚没有研究证据表明HF与肾功能正常者的肾脏不良结局有联系。研究者事先假设心衰与长期肾脏结局较差相关。

2004年10月1日至2006年9月30日期间,在3570865名预测肾小球滤过率(eGFR)≥60mL/ min/1.73 ㎡的美国退伍军人中,根据国际疾病分类第九版临床修订本心力衰竭(HF)诊断的内容,研究者确定了其中的156743名心衰患者。

调整了各种混杂因素之后,研究者采用Cox比例风险分析和Logistic回归分析研究了HF发生与慢性肾病(CKD)、CKD或死亡以及eGFR快速下降(大于 -5 mL/ min/1.73 ㎡/ y15)时间之间的关联。

HF患者的(平均±标准差)基线年龄和eGFR分别为 68±11年和78±14mL/ min/1.73 ㎡,在无HF的患者中,基线年龄和eGFR分别为59±14年和84±16mL/ min/1.73 ㎡。

在HF患者中,高血压糖尿病、周围血管病、慢性肺部疾病、中风和痴呆的患病率较高。在每病人年中,CKD的发生率在心衰患者中为69.0/1000,在无HF患者中为14.5/1000;eGFR的快速下降发生率在HF患者中为22%,在无HF患者中为8.5%。HF患者发生CKD、CKD或死亡以及eGFR快速下降的多参数调整风险分别为2.12、2.06和2.13。

因此,研究者得出结论:HF与CKD、CKD或死亡以及EGFR迅速下降的发生有关。因此早期诊断和治疗HF有助于降低长期的肾脏并发症风险。

原始出处:

George, L.K., S.K.G. Koshy, M.Z. Molnar, et al., Heart Failure Increases the Risk of Adverse Renal Outcomes in Patients With Normal Kidney Function. Circ Heart Fail, 2017. 10(8).

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    2018-02-27 yese
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    2017-08-08 zhaojie88
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    2017-08-08 slcumt
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    2017-08-06 天涯183

    非常好的文章,学习了,很受益

    0

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    2017-08-06 1ddf0692m34(暂无匿称)

    学习了,涨姿势

    0

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    2017-08-06 lovetcm

    这OR还是非常大的,而且如此大的样本的可信度也是比较高

    0

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    2017-08-06 hhh678

    henhao

    0

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    2017-08-06 fengxiangxin301

    优秀

    0

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