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JCEM：胆汁酸参与血糖控制

2013-07-15 desperado-c dxy

血糖胆汁酸
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最近的证据提示胆汁酸（BAs）通过TGR5激活和随后肠肽释放，以及法尼脂X受体激活和继发成纤维细胞生长因子释放（FGFs），参与血糖控制。为了探讨十二指肠内输注鹅去氧胆酸（CDCA）是否可以刺激FGF和肠肽分泌，从而对血糖稳态产生积极的影响。来自瑞士巴塞尔大学医院的Christoph Beglinger教授及其团队进行了一项研究，该研究发现BAs在血糖控制中发挥作用。该研究结果在线发表在2013年

最近的证据提示胆汁酸（BAs）通过TGR5激活和随后肠肽释放，以及法尼脂X受体激活和继发成纤维细胞生长因子释放（FGFs），参与血糖控制。为了探讨十二指肠内输注鹅去氧胆酸（CDCA）是否可以刺激FGF和肠肽分泌，从而对血糖稳态产生积极的影响。来自瑞士巴塞尔大学医院的Christoph Beglinger教授及其团队进行了一项研究，该研究发现BAs在血糖控制中发挥作用。该研究结果在线发表在2013年6月20日的《临床内分泌代谢杂志》（The journal of clinical endocrinology & metabolism）上。

该研究是一项随机、双盲、安慰剂对照、交叉实验，包括12例接受生理盐水、CDCA（5或15mmol/l）和脂肪酸（油酸钠）（单独或与5mmol/l CDCA一起）十二指肠内输注的健康受试者。60分钟后进行口服葡萄糖耐量试验（OGTT）。测量血浆胰高血糖素样肽-1（GLP-1）、酪酪肽、胆囊收缩素（CCK）、总Bas、FGF19、FGF21、C肽、胰岛素、血糖和胰高血糖素。

该研究结果表明，在第一个60分钟内，高浓度CDCA诱导GLP-1和CCK分泌小胆有意义的增加（P=0.016和P=0.011），然而，对血浆C肽、胰岛素和血糖没有影响。15mmol/lCDCA组OGTT后观察到C肽和胰岛素释放减少（P=0.013和P=0.011）。输注CDCA后，血浆BA和FGF19水平显著增加（P=0.001和P＜0.001）。

该研究发现，CDCA调节GLP-1和CCK分泌；作用很弱，而且没有影响血糖水平。OGTT后血浆BAs显著增加和胰岛素释放减少提示BAs在血糖控制中发挥作用，且独立于肠促胰岛素轴，并提示涉及法尼脂X受体激活通路。


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    2013-10-03 smallant2015

    #JCEM#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1777439, encodeId=7b4d1e7743912, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Oct 03 07:41:00 CST 2013, time=2013-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062820, encodeId=72872062820c4, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Fri Jan 24 05:41:00 CST 2014, time=2014-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272894, encodeId=29df12e289410, content=<a href='/topic/show?id=2f468983351' target=_blank style='color:#2F92EE;'>#血糖控制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89833, encryptionId=2f468983351, topicName=血糖控制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef84111, createdName=whlxd, createdTime=Wed Jul 17 05:41:00 CST 2013, time=2013-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579137, encodeId=d7af15e913732, content=<a href='/topic/show?id=372b834e673' target=_blank style='color:#2F92EE;'>#胆汁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83476, encryptionId=372b834e673, topicName=胆汁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a0616505872, createdName=108807375_62823132, createdTime=Wed Jul 17 05:41:00 CST 2013, time=2013-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=5924, encodeId=cf9d592421, content=嗯 不错 值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f1f84419, createdName=liufangivy, createdTime=Tue Jul 16 15:34:00 CST 2013, time=2013-07-16, status=1, ipAttribution=)]
    2014-01-24 achengzhao

    #JCE#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1777439, encodeId=7b4d1e7743912, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Oct 03 07:41:00 CST 2013, time=2013-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062820, encodeId=72872062820c4, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Fri Jan 24 05:41:00 CST 2014, time=2014-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272894, encodeId=29df12e289410, content=<a href='/topic/show?id=2f468983351' target=_blank style='color:#2F92EE;'>#血糖控制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89833, encryptionId=2f468983351, topicName=血糖控制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef84111, createdName=whlxd, createdTime=Wed Jul 17 05:41:00 CST 2013, time=2013-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579137, encodeId=d7af15e913732, content=<a href='/topic/show?id=372b834e673' target=_blank style='color:#2F92EE;'>#胆汁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83476, encryptionId=372b834e673, topicName=胆汁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a0616505872, createdName=108807375_62823132, createdTime=Wed Jul 17 05:41:00 CST 2013, time=2013-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=5924, encodeId=cf9d592421, content=嗯 不错 值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f1f84419, createdName=liufangivy, createdTime=Tue Jul 16 15:34:00 CST 2013, time=2013-07-16, status=1, ipAttribution=)]
    2013-07-17 whlxd

    #血糖控制#

    0

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    2013-07-17 108807375_62823132

    #胆汁#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1777439, encodeId=7b4d1e7743912, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Oct 03 07:41:00 CST 2013, time=2013-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062820, encodeId=72872062820c4, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Fri Jan 24 05:41:00 CST 2014, time=2014-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272894, encodeId=29df12e289410, content=<a href='/topic/show?id=2f468983351' target=_blank style='color:#2F92EE;'>#血糖控制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89833, encryptionId=2f468983351, topicName=血糖控制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef84111, createdName=whlxd, createdTime=Wed Jul 17 05:41:00 CST 2013, time=2013-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579137, encodeId=d7af15e913732, content=<a href='/topic/show?id=372b834e673' target=_blank style='color:#2F92EE;'>#胆汁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83476, encryptionId=372b834e673, topicName=胆汁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a0616505872, createdName=108807375_62823132, createdTime=Wed Jul 17 05:41:00 CST 2013, time=2013-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=5924, encodeId=cf9d592421, content=嗯 不错 值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f1f84419, createdName=liufangivy, createdTime=Tue Jul 16 15:34:00 CST 2013, time=2013-07-16, status=1, ipAttribution=)]
    2013-07-16 liufangivy

    嗯 不错 值得关注

    0

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