胆汁酸-话题@MedSci

#胆汁酸#

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objectUrl=/article/show_article.do?id=c74a80931144, replyNumber=0, likeNumber=85, createdTime=2024-01-19, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=0, avatar=, status=0, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=null, followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2118794, encodeId=5bc82118e94b5, content=<a href='/topic/show?id=24448348527' target=_blank style='color:#2F92EE;'>#胆汁酸#</a>可预测<a href='/topic/show?id=0bad820e112' target=_blank style='color:#2F92EE;'>#肺动脉高压#</a>患者的<a href='/topic/show?id=16ef10559ef8' target=_blank style='color:#2F92EE;'>#先天性门静脉分流#</a>情况, objectTitle=胆汁酸可预测肺动脉高压患者的先天性门静脉分流情况, objectType=article, longId=759604, objectId=535de5960460, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20221109/1668025168479_4754896.webp, objectUrl=/article/show_article.do?id=535de5960460, replyNumber=0, likeNumber=153, createdTime=2023-03-11, rootId=0, userName=showtest, userId=8f0715, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=535de5960460, moduleTitle=胆汁酸可预测肺动脉高压患者的先天性门静脉分流情况, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=535de5960460)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2100408, encodeId=64fc210040852, content=<a href='/topic/show?id=24448348527' target=_blank style='color:#2F92EE;'>#胆汁酸#</a>多种循环胆汁酸 (BA)，特别是结合 BA，与结肠直肠癌 (CRC) 的较高风险相关。而结肠直肠癌仍然是美国癌症死亡的第二大原因。初级 BA 由肝脏中的胆固醇合成，储存在胆囊中，然后释放到小肠中以帮助脂肪的消化和吸收。大约 5% 的初级 BA 逃逸肠肝循环，进入结肠，在那里它们可以被肠道细菌转化为次级 BA，例如脱氧胆酸。实验证据表明，继发性 BA 对结肠具有致癌性，而脱氧胆酸会导致 DNA 损伤并促进结肠肿瘤的生长。, objectTitle=胆汁酸, objectType=topic, longId=83485, objectId=null, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=null, replyNumber=0, likeNumber=100, createdTime=2022-11-14, rootId=0, userName=yangchou, userId=88b489038, projectId=1, avatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, status=1, hasArticle=0, attachment=null, ipAttribution=, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=886621, encodeId=1b988866213d, content=这个课题本来是解释：<a href='/topic/show?id=24448348527' target=_blank style='color:#2F92EE;'>#胆汁酸#</a>诱导<a href='/topic/show?id=3ed881343fa' target=_blank style='color:#2F92EE;'>#肝纤维化#</a>的机制的，这是临床上常见的现象，但是机制并不清楚。过去认为可能是<a href='/topic/show?id=8c2120038ff' target=_blank style='color:#2F92EE;'>#上皮间质化#</a>（EMT）导致的，当然炎症信号通路肯定起关键作用，因此，<a href='/topic/show?id=7ba812e35f3' target=_blank style='color:#2F92EE;'>#NF-κB#</a>途径是必然参与其中的，其它信号如TGF-beta, SMAD3等都会参与其中的。同时，肝纤维化和<a href='/topic/show?id=370d8126914' target=_blank style='color:#2F92EE;'>#肝癌#</a>时，<a href='/topic/show?id=4a0281923d' target=_blank style='color:#2F92EE;'>#GP73#</a>水平上升，它是<a href='/topic/show?id=36a8102336cb' target=_blank style='color:#2F92EE;'>#高尔基体#</a>上的重要蛋白，因此，将它们关联起来，确实是一个比较巧妙的构思！青年基金能想到这样，相当不错。, objectTitle=胆汁酸通过激活NF-κB途径及破坏高尔基体结构上调肝纤维化/肝硬化患者血清GP73水平的机制研究, objectType=nsfc, longId=905737, objectId=0318905e375e, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/sci/nsfc_show.do?id=0318905e375e, replyNumber=0, likeNumber=345, createdTime=2020-09-19, rootId=0, userName=lovetcm, userId=7a3710, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=0318905e375e, moduleTitle=胆汁酸通过激活NF-κB途径及破坏高尔基体结构上调肝纤维化/肝硬化患者血清GP73水平的机制研究, moduleType=nsfc, hrefUrl=https://www.medsci.cn/sci/nsfc_show.do?id=0318905e375e)], followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=882239, encodeId=ad3888223906, content=<a href='/topic/show?id=24448348527' target=_blank style='color:#2F92EE;'>#胆汁酸#</a>广泛参与包括<a href='/topic/show?id=735a81364b7' target=_blank style='color:#2F92EE;'>#肝细胞癌#</a>、胃癌、食道癌和胰腺癌等人恶性肿瘤的发病机理, objectTitle=Cell Death Dis：FXR通过拮抗Wnt/β-catenin信号发挥抑癌作用, objectType=article, longId=200134, objectId=d19b2001341a, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/202091/1598970456672_2110107.PNG, objectUrl=/article/show_article.do?id=d19b2001341a, replyNumber=0, likeNumber=345, createdTime=2020-09-02, rootId=0, userName=lovetcm, userId=7a3710, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=d19b2001341a, moduleTitle=Cell Death Dis：FXR通过拮抗Wnt/β-catenin信号发挥抑癌作用, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=d19b2001341a)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=811409, encodeId=b48d811409c9, content=那多吃点胆固醇类食物，是不是也可以治疗便秘呢？<a href='/topic/show?id=13032e051f7' target=_blank style='color:#2F92EE;'>#便秘#</a><a href='/topic/show?id=24448348527' target=_blank style='color:#2F92EE;'>#胆汁酸#</a>, objectTitle=AP&T:埃洛比昔巴特在慢性便秘中的作用与粪便脱氧胆酸有关, objectType=article, longId=199689, objectId=3738199689bc, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/2020819/1597819750693_2071404.jpg, objectUrl=/article/show_article.do?id=3738199689bc, replyNumber=0, likeNumber=273, createdTime=2020-08-20, rootId=0, userName=Jessica, userId=3a345397082, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=3738199689bc, moduleTitle=AP&T:埃洛比昔巴特在慢性便秘中的作用与粪便脱氧胆酸有关, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=3738199689bc)], followStatus=false, userIsMember=false, type=1, lengthMark=0)] 梅斯话题小助手

胆汁酸

2020-05-29

梅斯管理员 (审核中...)

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#胆固醇# #胆汁酸# #脂肪代谢# #有益微生物#

7小时前发表于上海

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#肝细胞癌# #肝硬化# #胆汁酸#

Hepatol Commun：血清总胆汁酸水平与肝硬化患者发生HCC的风险增加相关

2024-12-13发表于陕西省

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#炎症性肠病# #中医药# #靶向药物# #胆汁酸# #肠道微生物群# #胆汁酸受体#

J Ethnopharmacol：胆汁酸作为炎症性肠病的信号分子：对治疗策略的影响

2024-10-22发表于上海

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#能量代谢# #抗生素# #胆汁酸# #肠道微生物群# #粪便微生物群移植# #附子#

Front Pharmacol：附子能量代谢促进作用与肠道菌群和胆汁酸受体TGR5-UCP1信号通路有关

2024-09-27发表于上海

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#胆汁酸# #溃疡性结肠炎# #四逆散# #氧甾醇# #肝X受体(LXRs)#

J Ethnopharmacol：四逆散通过调节胆固醇代谢减轻溃疡性结肠炎小鼠肠道和肝脏损伤

2024-08-31发表于上海

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#中医药# #胆汁酸# #短链脂肪酸# #脂质组学# #泽泻白术汤#

J Ethnopharmacol：泽泻白术汤通过肠-脂肪组织改善非酒精性脂肪肝

2024-08-28发表于上海

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#肥胖# #肠道菌群# #胆汁酸# #M2巨噬细胞# #生脉散#

Phytomedicine：生脉散通过肠道微生物源性胆汁酸促进M2巨噬细胞极化和产热，缓解小鼠高脂饮食所致肥胖

2024-08-22发表于上海

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#胆汁酸# #细胞应激反应#

eGastroenterology：胆汁酸在肝脏病理生理过程中调控细胞应激反应的机制

2024-06-15发表于上海

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#胆汁酸# #肠道微生物组# #胆囊#

2024-03-26发表于上海

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#微生物组# #甘氨酸# #胆汁酸# #牛磺酸#

2024-03-04发表于上海

侠胆医心 (审核中...)