J Infect Dis:感染丙型肝炎病毒可危及心脏健康

2015-08-13 sunshine 译 MedSci原创

众所周知,感染丙型肝炎病毒后可危害肝脏健康,但来自约翰霍普金斯的一项新的研究表明,感染丙型肝炎病毒还可危害心脏的健康,该研究成果发表于《传染病杂志》。研究发现源于一项大型的男同性恋研究,该研究中部分人感染了HIV,并追踪观察此人群HIV感染的风险及疾病的进展。该研究所选研究对象既有HIV感染者也有丙型肝炎病毒感染者,通常此两种感染并存。尽管人们已知HIV感染可增加心脏病的患病风险,但是本研究表明丙


众所周知,感染丙型肝炎病毒后可危害肝脏健康,但来自约翰霍普金斯的一项新的研究表明,感染丙型肝炎病毒还可危害心脏的健康,该研究成果发表于《传染病杂志》。

研究发现源于一项大型的男同性恋研究,该研究中部分人感染了HIV,并追踪观察此人群HIV感染的风险及疾病的进展。该研究所选研究对象既有HIV感染者也有丙型肝炎病毒感染者,通常此两种感染并存。

尽管人们已知HIV感染可增加心脏病的患病风险,但是本研究表明丙型肝炎病毒感染也可增加心脏病的患病风险且为其发生的一个独立危险因素。

研究人员发现,丙型肝炎病毒长期慢性感染者其动脉中出现异常斑块沉积的可能更大。虽然并不清楚丙型肝炎病毒感染导致斑块沉积的具体机制,但是研究人员表示,该研究所提供的证据足够充分,因此感染此病毒的人群应谨慎监测自身的心脏病相关症状。

研究人员评估了994名年龄在40-70岁的男性,所有研究对象均未患有明显的心脏疾病。随访观察发现其中613名感染了HIV,17名感染了丙型肝炎病毒,70名同时感染了这两种病毒。对所有研究对象行心脏CT扫描,并评估其心脏血管内脂肪和钙的沉积。感染了丙型肝炎病毒(不论是否感染HIV)的患者较未感染此病毒的患者出现动脉钙化斑块的概率高了30%。感染HIV或丙型肝炎病毒的患者出现非钙化斑块的概率高了42%。此外,血液中丙型肝炎病毒水平较高者,其出现动脉阻塞的危险较未感染此病毒者高50%。血液中丙型肝炎病毒浓度较高意味着感染不受药物或免疫系统的控制。而感染控制的不好则可能会导致全身炎症,从而损伤血管,导致心脏病的发生。

控制丙型肝炎病毒的感染可组织其对肝脏的长期损伤,但是该研究人员提出:是否可研发出一种新的药物可帮助90%的患者在短短几个月内便清除病毒,同时还可以阻止动脉中斑块的形成以降低心脏病的发病风险。

原始出处:

McKibben RA, Haberlen SA, Post WS, Brown TT, Budoff M, Witt MD, Kingsley LA, Palella FJ Jr, Thio CL, Seaberg EC.Chronic Hepatitis C Virus Infection Is Associated with Subclinical Coronary Atherosclerosis in the Multicenter AIDS Cohort Study (MACS): a Cross-Sectional Study.J Infect Dis. 2015 Jul 27. pii: jiv396. 


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    2015-11-07 xjbtdbs150wgf

    2014年已经有了快速短期内治愈丙肝的药物了啊

    0

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    2015-08-15 lecoo

    学习了。。

    0

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    2015-08-15 byzh1990

    需要重视

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=42787, encodeId=6ab442e8783, content=2014年已经有了快速短期内治愈丙肝的药物了啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151101/IMG5635562CC617F7689.jpg, createdBy=bf351605554, createdName=xjbtdbs150wgf, createdTime=Sat Nov 07 23:57:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012003, encodeId=74302012003ed, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Feb 09 08:00:00 CST 2016, time=2016-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274558, encodeId=3c8d12e455847, content=<a href='/topic/show?id=30872089e03' target=_blank style='color:#2F92EE;'>#丙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20897, encryptionId=30872089e03, topicName=丙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Sat Aug 15 14:00:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429529, encodeId=341d1429529bf, content=<a href='/topic/show?id=534e2090181' target=_blank style='color:#2F92EE;'>#丙型肝炎病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20901, encryptionId=534e2090181, topicName=丙型肝炎病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a26a4213133, createdName=anan, createdTime=Sat Aug 15 14:00:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515042, encodeId=820915150427e, content=<a href='/topic/show?id=3806514304b' target=_blank style='color:#2F92EE;'>#心脏健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51430, encryptionId=3806514304b, topicName=心脏健康)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0c810711035, createdName=1179102698_36768929, createdTime=Sat Aug 15 14:00:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35625, encodeId=7b623562586, content=学习了。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sat Aug 15 12:42:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35604, encodeId=fd6c356044b, content=需要重视, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a25c1635554, createdName=byzh1990, createdTime=Sat Aug 15 01:15:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35586, encodeId=5a6d355867f, content=丙肝是被人类搞定的一种肝炎了, beContent=null, objectType=article, channel=null, level=null, likeNumber=176, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Aug 14 21:14:00 CST 2015, time=2015-08-14, status=1, ipAttribution=)]
    2015-08-14 medcardio

    丙肝是被人类搞定的一种肝炎了

    0

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