Neurology:回国军人轻度颅脑损伤的流行病学及预后如何?

2017-03-18 xing.T MedSci原创

在最近部署的士兵非临床人群中,有相当比例的持续性mTBI的士兵部署后3个月出现症状。未来的研究需要进行更长时间的随访以确定症状的消失情况。

轻度创伤性脑损伤(mTBI;震荡)在从战场归国士兵中很常见,目前仍缺少确切的证据来反映其预后。近日,神经病学领域权威取杂志Neurology上针对这一问题发表了一篇研究文章。

研究人员对在2009年至2014年期间从阿富汗或伊拉克2个军事基地的非医疗原因撤回的25000名士兵进行mTBI筛查。研究人员邀请了一个随机样本参与了该研究,研究人员对这些筛查阳性的参与者进行多次采样,发现了557例mTBI患者和1010例对照者,其中366名患者和599名对照者完成了3个月的随访评价。筛选mTBI的标准衡量是根据俄亥俄州立大学创伤性脑损伤识别方法。研究人员采用神经行为症状调查表测量震荡后症状(PCS)。报告的症状位于严重或非常严重的水平被认为与临床相关。

在最后一次部署后报告PCS的患者随访3个月后,大约有一半(47%)的士兵患有持续的mTBI,相比于对照者为25%:调整后的比值比为2.4(1.8-3.2)。最常见的症状(病例组 vs. 对照组)是睡眠问题(30% vs. 14%)、健忘(21% vs. 9%)、烦躁不安(17% vs. 8%)和头痛(15% vs. 5%)。mTBI患者相比于对照者接受康复治疗和中等或健康状况不佳的可能性增加2倍。其他预测PCS的因素包括创伤后应激、战斗曝露和非头部疼痛。大多数的病例和对照者在最近一次部署早些天会报告创伤性脑损伤。

由此可见,在最近部署的士兵非临床人群中,有相当比例的持续性mTBI的士兵部署后3个月出现症状。未来的研究需要进行更长时间的随访以确定症状的消失情况。

原始出处:

Karen Schwab, et al. Epidemiology and prognosis of mild traumatic brain injury in returning soldiers A cohort study. Neurology.http://dx.doi.org/10.1212/WNL.0000000000003839

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    2017-11-21 yinhl1978
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    2017-03-20 zhouqu_8
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    2017-03-20 xugumin