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Nat Commun：阻断一种癌细胞通路或可诱发促癌新型通路的产生

2016-05-19 生物谷 梅斯医学

癌细胞通路直肠癌癌细胞逃脱
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ERK1和ERK2作为广泛表达的信号分子可以驱动三分之一结直肠癌患者机体癌症的生长，近日，来自加利福尼亚大学的研究人员在研究ERK1和ERK2的潜在靶点时发现，当ERK1和ERK2途径被抑制后，一种备用的通路就会立马出现来促进肿瘤细胞继续增殖。

图片来源：www.sciencedaily.com

ERK1和ERK2作为广泛表达的信号分子可以驱动三分之一结直肠癌患者机体癌症的生长，近日，来自加利福尼亚大学的研究人员在研究ERK1和ERK2的潜在靶点时发现，当ERK1和ERK2途径被抑制后，一种备用的通路就会立马出现来促进肿瘤细胞继续增殖，相关研究刊登于国际杂志Nature Communications上。

文章中，研究人员对小鼠模型和人类结直肠癌细胞系进行研究，利用一种组合型药物制剂来对ERK1/2及ERK5途径进行靶向作用来阻断结直肠癌的发展；ERK途径在胚胎发育及组织修复过程中扮演着重要角色，因为其可以指导细胞繁殖并且开始分裂，但一旦超过某个限度就会激活癌细胞产生并且增殖。

研究者Eyal Raz说道，靶向作用ERK1/2的疗法很有可能会失败，因为这种机制会通过另外一种通路来促进癌细胞增殖；此前研究中我们发现，ERK5对于结直肠癌而言似乎并不重要，而ERK5途径是肿瘤细胞的一种逃脱途径，因此ERK1/2及ERK5抑制剂的组合或可有效治疗结直肠癌患者。

目前在美国有120万结直肠癌患者，据估计2016年将会有134，490名新发结直肠癌患者；研究者认为，如果阻断一种癌症通路，癌细胞通常就会发生突变并且寻找其它通路来继续繁殖恶化；通常情况下，突变数周或数月就会发生，但在其它时候，肿瘤并不需要产生突变就可以寻找到一种逃脱靶向疗法作用的途径，当我们一旦发现癌细胞的候补途径并且及时阻断该途径发生，就会有效抑制癌细胞逃脱了。

本文研究中，在开始进行癌症患者临床试验前，研究人员还调查了其它抑制剂结合ERK5抑制剂在抑制临床前小鼠模型机体中的人类结直肠癌细胞的效力。当然研究人员还期待通过后期更加深入的研究来取得更多的成果。

原始出处：

Petrus R,et al.ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation.Nature Communications.doi:10.1038/ncomms11551.

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    2016-08-17 changhe722

    #促癌#

    0

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    2016-12-03 liuli5079

    #COMMUN#

    0

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    2017-01-20 liye789132251

    #Nat#

    0

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    2016-09-30 1e10c84am36(暂无匿称)

    拜读，好文

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1677563, encodeId=0d5f16e756356, content=<a href='/topic/show?id=fa5c2e100cd' target=_blank style='color:#2F92EE;'>#促癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27100, encryptionId=fa5c2e100cd, topicName=促癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ab727554053, createdName=changhe722, createdTime=Wed Aug 17 01:34:00 CST 2016, time=2016-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2086863, encodeId=196e20868639c, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sat Dec 03 03:34:00 CST 2016, time=2016-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1881051, encodeId=dcca1881051af, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Jan 20 15:34:00 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138144, encodeId=15ec138144ed, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:19:13 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710030, encodeId=fb061e10030a9, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97676, encryptionId=7ac59e67604, topicName=阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5ca31824852, createdName=41514497@qq.com, createdTime=Thu Jun 23 21:34:00 CST 2016, time=2016-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88235, encodeId=c42d8823507, content=不好研究啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=61191606034, createdName=mym86538653, createdTime=Thu Jun 02 07:59:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88234, encodeId=a3e68823477, content=都会有这种问题么, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=61191606034, createdName=mym86538653, createdTime=Thu Jun 02 07:58:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252095, encodeId=7ad1125209512, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri May 20 23:34:00 CST 2016, time=2016-05-20, status=1, ipAttribution=)]
    2016-06-23 41514497@qq.com

    #阻断#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1677563, encodeId=0d5f16e756356, content=<a href='/topic/show?id=fa5c2e100cd' target=_blank style='color:#2F92EE;'>#促癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27100, encryptionId=fa5c2e100cd, topicName=促癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ab727554053, createdName=changhe722, createdTime=Wed Aug 17 01:34:00 CST 2016, time=2016-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2086863, encodeId=196e20868639c, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sat Dec 03 03:34:00 CST 2016, time=2016-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1881051, encodeId=dcca1881051af, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Jan 20 15:34:00 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138144, encodeId=15ec138144ed, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:19:13 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710030, encodeId=fb061e10030a9, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97676, encryptionId=7ac59e67604, topicName=阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5ca31824852, createdName=41514497@qq.com, createdTime=Thu Jun 23 21:34:00 CST 2016, time=2016-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88235, encodeId=c42d8823507, content=不好研究啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=61191606034, createdName=mym86538653, createdTime=Thu Jun 02 07:59:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88234, encodeId=a3e68823477, content=都会有这种问题么, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=61191606034, createdName=mym86538653, createdTime=Thu Jun 02 07:58:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252095, encodeId=7ad1125209512, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri May 20 23:34:00 CST 2016, time=2016-05-20, status=1, ipAttribution=)]
    2016-06-02 mym86538653

    不好研究啦

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1677563, encodeId=0d5f16e756356, content=<a href='/topic/show?id=fa5c2e100cd' target=_blank style='color:#2F92EE;'>#促癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27100, encryptionId=fa5c2e100cd, topicName=促癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ab727554053, createdName=changhe722, createdTime=Wed Aug 17 01:34:00 CST 2016, time=2016-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2086863, encodeId=196e20868639c, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sat Dec 03 03:34:00 CST 2016, time=2016-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1881051, encodeId=dcca1881051af, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Jan 20 15:34:00 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138144, encodeId=15ec138144ed, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:19:13 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710030, encodeId=fb061e10030a9, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97676, encryptionId=7ac59e67604, topicName=阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5ca31824852, createdName=41514497@qq.com, createdTime=Thu Jun 23 21:34:00 CST 2016, time=2016-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88235, encodeId=c42d8823507, content=不好研究啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=61191606034, createdName=mym86538653, createdTime=Thu Jun 02 07:59:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88234, encodeId=a3e68823477, content=都会有这种问题么, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=61191606034, createdName=mym86538653, createdTime=Thu Jun 02 07:58:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252095, encodeId=7ad1125209512, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri May 20 23:34:00 CST 2016, time=2016-05-20, status=1, ipAttribution=)]
    2016-06-02 mym86538653

    都会有这种问题么

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1677563, encodeId=0d5f16e756356, content=<a href='/topic/show?id=fa5c2e100cd' target=_blank style='color:#2F92EE;'>#促癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27100, encryptionId=fa5c2e100cd, topicName=促癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ab727554053, createdName=changhe722, createdTime=Wed Aug 17 01:34:00 CST 2016, time=2016-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2086863, encodeId=196e20868639c, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sat Dec 03 03:34:00 CST 2016, time=2016-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1881051, encodeId=dcca1881051af, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Jan 20 15:34:00 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138144, encodeId=15ec138144ed, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:19:13 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710030, encodeId=fb061e10030a9, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97676, encryptionId=7ac59e67604, topicName=阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5ca31824852, createdName=41514497@qq.com, createdTime=Thu Jun 23 21:34:00 CST 2016, time=2016-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88235, encodeId=c42d8823507, content=不好研究啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=61191606034, createdName=mym86538653, createdTime=Thu Jun 02 07:59:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88234, encodeId=a3e68823477, content=都会有这种问题么, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=61191606034, createdName=mym86538653, createdTime=Thu Jun 02 07:58:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252095, encodeId=7ad1125209512, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri May 20 23:34:00 CST 2016, time=2016-05-20, status=1, ipAttribution=)]
    2016-05-20 yxch36

    #癌细胞#

    0