J Glaucoma:阻塞性睡眠呼吸暂停与视网膜神经纤维层厚度有关(荟萃分析)

2016-04-05 Mechront 译 MedSci原创

近期发表在J Glaucoma的研究称,睡眠呼吸暂停综合症(OSAS)会增加视网膜神经纤维层厚度损失风险。我国学者珠海中山大学的研究人员对2011-2014年的6项研究(涉及1034只眼睛)进行了荟萃分析,纳入的研究评估了至少一项以下数据:平均视网膜神经纤维层(RNFL)厚度、四象限(上、鼻、下、颞)RNFL厚度、OSAS不同阶段的RNFL厚度。排除了可疑或确证青光眼、视神经炎、慢性葡萄膜炎、视网


近期发表在J Glaucoma的研究称,睡眠呼吸暂停综合症(OSAS)会增加视网膜神经纤维层厚度损失风险。

我国学者珠海中山大学的研究人员对2011-2014年的6项研究(涉及1034只眼睛)进行了荟萃分析,纳入的研究评估了至少一项以下数据:平均视网膜神经纤维层(RNFL)厚度、四象限(上、鼻、下、颞)RNFL厚度、OSAS不同阶段的RNFL厚度。

排除了可疑或确证青光眼、视神经炎、慢性葡萄膜炎、视网膜色素变性、眼外伤、前次眼手术史、多发性硬化症、帕金森氏症和中风的患者。

荟萃分析结果显示,轻度OSAS患者(无异质性)合并后RNFL厚度相差–2.05 µm;中度OSAS患者(无异质性)合并后RNFL厚度相差–2.49 µm;重度OSAS患者(显著异质性)合并后RNFL厚度相差–6.36 µm(P < .003)。

上象限(无异质性)RNFL厚度相差–1.83 µm;鼻象限(无异质性)RNFL厚度相差 –2.32 µm;下象限(无异质性)RNFL厚度相差 –3.31 µm;颞象限(无异质性)RNFL厚度相差–0.75 µm。

研究者写道:“我们有理由相信,OSAS可以通过降低氧气供应造成青光眼,增加眼压,加重视野缺陷和减少视网膜神经纤维层等。不过建立OSAS和RNFL厚度之间潜在的因果关系还需要进一步的大规模、长期的前瞻性研究。”

原始出处:


Zhao XJ, et al.Obstructive Sleep Apnea and Retinal Nerve Fiber Layer Thickness: A Meta-analysis. J Glaucoma. 2016;doi:10.1097/IJG.0000000000000349.

Obstructive sleep apnea associated with decreased retinal nerve fiber layer thickness.
Healio.April 4, 2016

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    2016-12-29 aliceclz
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  4. 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createdName=aliceclz, createdTime=Thu Dec 29 21:06:00 CST 2016, time=2016-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696675, encodeId=6b8716966e54e, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Sun Jan 15 14:06:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2018085, encodeId=b77e20180852a, content=<a href='/topic/show?id=8adc90e9115' target=_blank style='color:#2F92EE;'>#视网膜神经纤维层厚度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90791, 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channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90786, encryptionId=9cd690e860a, topicName=视网膜神经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Sat Apr 23 06:06:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681302, encodeId=0c5f16813020e, content=<a href='/topic/show?id=366b8e2299e' target=_blank style='color:#2F92EE;'>#荟萃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87229, encryptionId=366b8e2299e, topicName=荟萃)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c12d27855367, createdName=venlin, createdTime=Tue Jan 17 14:06:00 CST 2017, time=2017-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989005, encodeId=bbbb198900553, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Mar 21 12:06:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85091, encodeId=cb288509131, content=明天就带我爸去检查视网膜, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73c1706459, createdName=1de92651m76(暂无匿称), createdTime=Mon May 09 18:30:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76667, encodeId=a9ebe66672d, content=无限期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b08d1688793, createdName=1de5193fm68(暂无匿称), createdTime=Sun Apr 10 13:01:00 CST 2016, time=2016-04-10, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1836880, encodeId=47ca1836880c4, content=<a href='/topic/show?id=1f188e230c5' target=_blank style='color:#2F92EE;'>#荟萃分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87230, encryptionId=1f188e230c5, topicName=荟萃分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Thu Jan 12 02:06:00 CST 2017, time=2017-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914180, encodeId=5c9d19141804a, content=<a href='/topic/show?id=5ee629957f' target=_blank style='color:#2F92EE;'>#AUC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2995, encryptionId=5ee629957f, topicName=AUC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, 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channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90786, encryptionId=9cd690e860a, topicName=视网膜神经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Sat Apr 23 06:06:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681302, encodeId=0c5f16813020e, content=<a href='/topic/show?id=366b8e2299e' target=_blank style='color:#2F92EE;'>#荟萃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87229, encryptionId=366b8e2299e, topicName=荟萃)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c12d27855367, createdName=venlin, createdTime=Tue Jan 17 14:06:00 CST 2017, time=2017-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989005, encodeId=bbbb198900553, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Mar 21 12:06:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85091, encodeId=cb288509131, content=明天就带我爸去检查视网膜, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73c1706459, createdName=1de92651m76(暂无匿称), createdTime=Mon May 09 18:30:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76667, encodeId=a9ebe66672d, content=无限期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b08d1688793, createdName=1de5193fm68(暂无匿称), createdTime=Sun Apr 10 13:01:00 CST 2016, time=2016-04-10, status=1, ipAttribution=)]
    2016-05-18 amyloid
  6. [GetPortalCommentsPageByObjectIdResponse(id=1836880, encodeId=47ca1836880c4, content=<a href='/topic/show?id=1f188e230c5' target=_blank style='color:#2F92EE;'>#荟萃分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87230, encryptionId=1f188e230c5, topicName=荟萃分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Thu Jan 12 02:06:00 CST 2017, time=2017-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914180, encodeId=5c9d19141804a, content=<a href='/topic/show?id=5ee629957f' target=_blank style='color:#2F92EE;'>#AUC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2995, encryptionId=5ee629957f, topicName=AUC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, createdName=aliceclz, createdTime=Thu Dec 29 21:06:00 CST 2016, time=2016-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696675, encodeId=6b8716966e54e, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Sun Jan 15 14:06:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2018085, encodeId=b77e20180852a, content=<a href='/topic/show?id=8adc90e9115' target=_blank style='color:#2F92EE;'>#视网膜神经纤维层厚度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90791, encryptionId=8adc90e9115, topicName=视网膜神经纤维层厚度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25c8396, createdName=ssnine, createdTime=Sat Oct 22 06:06:00 CST 2016, time=2016-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804479, encodeId=3b0418044e9ca, content=<a href='/topic/show?id=0df6e7240df' target=_blank style='color:#2F92EE;'>#纤维层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77240, encryptionId=0df6e7240df, topicName=纤维层)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Wed May 18 05:06:00 CST 2016, time=2016-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801549, encodeId=442a1801549a0, content=<a href='/topic/show?id=9cd690e860a' target=_blank style='color:#2F92EE;'>#视网膜神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90786, encryptionId=9cd690e860a, topicName=视网膜神经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Sat Apr 23 06:06:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681302, encodeId=0c5f16813020e, content=<a href='/topic/show?id=366b8e2299e' target=_blank style='color:#2F92EE;'>#荟萃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87229, encryptionId=366b8e2299e, topicName=荟萃)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c12d27855367, createdName=venlin, createdTime=Tue Jan 17 14:06:00 CST 2017, time=2017-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989005, encodeId=bbbb198900553, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Mar 21 12:06:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85091, encodeId=cb288509131, content=明天就带我爸去检查视网膜, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73c1706459, createdName=1de92651m76(暂无匿称), createdTime=Mon May 09 18:30:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76667, encodeId=a9ebe66672d, content=无限期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b08d1688793, createdName=1de5193fm68(暂无匿称), createdTime=Sun Apr 10 13:01:00 CST 2016, time=2016-04-10, status=1, ipAttribution=)]
  7. 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channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90786, encryptionId=9cd690e860a, topicName=视网膜神经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Sat Apr 23 06:06:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681302, encodeId=0c5f16813020e, content=<a href='/topic/show?id=366b8e2299e' target=_blank style='color:#2F92EE;'>#荟萃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87229, encryptionId=366b8e2299e, topicName=荟萃)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c12d27855367, createdName=venlin, createdTime=Tue Jan 17 14:06:00 CST 2017, time=2017-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989005, encodeId=bbbb198900553, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Mar 21 12:06:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85091, encodeId=cb288509131, content=明天就带我爸去检查视网膜, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73c1706459, createdName=1de92651m76(暂无匿称), createdTime=Mon May 09 18:30:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76667, encodeId=a9ebe66672d, content=无限期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b08d1688793, createdName=1de5193fm68(暂无匿称), createdTime=Sun Apr 10 13:01:00 CST 2016, time=2016-04-10, status=1, ipAttribution=)]
    2017-01-17 venlin
  8. 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objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b08d1688793, createdName=1de5193fm68(暂无匿称), createdTime=Sun Apr 10 13:01:00 CST 2016, time=2016-04-10, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1836880, encodeId=47ca1836880c4, content=<a href='/topic/show?id=1f188e230c5' target=_blank style='color:#2F92EE;'>#荟萃分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87230, encryptionId=1f188e230c5, topicName=荟萃分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Thu Jan 12 02:06:00 CST 2017, time=2017-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914180, encodeId=5c9d19141804a, content=<a href='/topic/show?id=5ee629957f' target=_blank style='color:#2F92EE;'>#AUC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2995, encryptionId=5ee629957f, topicName=AUC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, 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href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Mar 21 12:06:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85091, encodeId=cb288509131, content=明天就带我爸去检查视网膜, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73c1706459, createdName=1de92651m76(暂无匿称), createdTime=Mon May 09 18:30:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76667, encodeId=a9ebe66672d, content=无限期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b08d1688793, createdName=1de5193fm68(暂无匿称), createdTime=Sun Apr 10 13:01:00 CST 2016, time=2016-04-10, status=1, ipAttribution=)]
    2016-05-09 1de92651m76(暂无匿称)

    明天就带我爸去检查视网膜

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1836880, encodeId=47ca1836880c4, content=<a href='/topic/show?id=1f188e230c5' target=_blank style='color:#2F92EE;'>#荟萃分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87230, encryptionId=1f188e230c5, topicName=荟萃分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Thu Jan 12 02:06:00 CST 2017, time=2017-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914180, encodeId=5c9d19141804a, content=<a href='/topic/show?id=5ee629957f' target=_blank style='color:#2F92EE;'>#AUC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2995, encryptionId=5ee629957f, topicName=AUC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, 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objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b08d1688793, createdName=1de5193fm68(暂无匿称), createdTime=Sun Apr 10 13:01:00 CST 2016, time=2016-04-10, status=1, ipAttribution=)]
    2016-04-10 1de5193fm68(暂无匿称)

    无限期待

    0