Lancet:生吃海鱼导致异尖线虫病-案例报道

2016-05-06 Mechront 译 MedSci原创

患者男,49岁,因胃灼热渐加重3月就诊。既往史:2型糖尿病、高血压。患者经常吃生凤尾鱼伴醋沙司。平素健康状况良好。查体:未见明显异常。辅助检查:外周血嗜酸性细胞增多 1.7×103/μL(正常值为0.5×103/μL)。胃镜:胃食管反流病和Barrett's食管的表现特征(经病理检查确认);一个孤立的、增厚的胃褶(如下图,取组织活检);无肉眼可见的红斑、水肿、糜烂性胃炎、溃疡、肿瘤样结节或蠕虫。组

患者男,49岁,因胃灼热渐加重3月就诊。

既往史:2型糖尿病高血压

患者经常吃生凤尾鱼伴醋沙司。平素健康状况良好。

查体:未见明显异常。

辅助检查:外周血嗜酸性细胞增多 1.7×103/μL(正常值为0.5×103/μL)。

胃镜:胃食管反流病和Barrett's食管的表现特征(经病理检查确认);一个孤立的、增厚的胃褶(如下图,取组织活检);无肉眼可见的红斑、水肿、糜烂性胃炎、溃疡、肿瘤样结节或蠕虫。



组织活检:明显的嗜酸性粒细胞炎性浸润;胃粘膜下存在异尖线虫的幼虫(如下图)。



此外患者血清中异尖线虫特异性IgE升高。

诊断:异尖线虫病,嗜酸性胃炎。

治疗上使用奥美拉唑治疗胃食管反流病,建议患者避免摄入可能受污染的海鲜,降低异尖线虫所致过敏反应风险。

确诊10个月后,患者外周血嗜酸性粒细胞计数恢复正常,复查胃镜和胃组织活检未见明显异常。

异尖线虫病常常是因为患者生食了含活幼虫的海鱼而感染所致,最常见的临床表现包括了食管、胃、肠道、异位和过敏性疾病,像本例中因嗜酸粒细胞增多继发无症状的嗜酸性胃炎也是可以出现的。由于生吃海鱼这种饮食方式的流行,临床医生应该对该疾病保持高度警惕,尤其是患者有已知的生吃海鱼的饮食习惯时。

原始出处:

Miguel F Carrascosa,Juan Corral Mones,et al.A man with unsuspected marine eosinophilic gastritis.The Lancet.DOI: http://dx.doi.org/10.1016/S1473-3099(14)70892-8

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  1. [GetPortalCommentsPageByObjectIdResponse(id=106957, encodeId=a67610695ea7, content=深入学习,好文值得点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Aug 29 20:34:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104070, encodeId=bdeb1040e072, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Aug 26 06:46:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828470, encodeId=97be18284e06c, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Sep 26 23:04:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85209, encodeId=7ca18520945, content=以后还是少吃三文鱼为好, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Tue May 10 07:03:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84963, encodeId=379384963c5, content=三文鱼也是这样吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Mon May 09 11:13:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493415, encodeId=84f41493415b6, content=<a href='/topic/show?id=ebbbe7621c7' target=_blank style='color:#2F92EE;'>#线虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77621, encryptionId=ebbbe7621c7, topicName=线虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=133b9055992, createdName=zblhy, createdTime=Sun May 08 08:04:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84439, encodeId=a12684439ac, content=首次听说, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Fri May 06 18:25:00 CST 2016, time=2016-05-06, status=1, ipAttribution=)]
    2016-08-29 ylzr123

    深入学习,好文值得点赞!

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=106957, encodeId=a67610695ea7, content=深入学习,好文值得点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Aug 29 20:34:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104070, encodeId=bdeb1040e072, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Aug 26 06:46:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828470, encodeId=97be18284e06c, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Sep 26 23:04:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85209, encodeId=7ca18520945, content=以后还是少吃三文鱼为好, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Tue May 10 07:03:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84963, encodeId=379384963c5, content=三文鱼也是这样吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Mon May 09 11:13:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493415, encodeId=84f41493415b6, content=<a href='/topic/show?id=ebbbe7621c7' target=_blank style='color:#2F92EE;'>#线虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77621, encryptionId=ebbbe7621c7, topicName=线虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=133b9055992, createdName=zblhy, createdTime=Sun May 08 08:04:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84439, encodeId=a12684439ac, content=首次听说, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Fri May 06 18:25:00 CST 2016, time=2016-05-06, status=1, ipAttribution=)]
    2016-08-26 忠诚向上

    好好学习一下

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=106957, encodeId=a67610695ea7, content=深入学习,好文值得点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Aug 29 20:34:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104070, encodeId=bdeb1040e072, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Aug 26 06:46:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828470, encodeId=97be18284e06c, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Sep 26 23:04:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85209, encodeId=7ca18520945, content=以后还是少吃三文鱼为好, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Tue May 10 07:03:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84963, encodeId=379384963c5, content=三文鱼也是这样吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Mon May 09 11:13:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493415, encodeId=84f41493415b6, content=<a href='/topic/show?id=ebbbe7621c7' target=_blank style='color:#2F92EE;'>#线虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77621, encryptionId=ebbbe7621c7, topicName=线虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=133b9055992, createdName=zblhy, createdTime=Sun May 08 08:04:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84439, encodeId=a12684439ac, content=首次听说, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Fri May 06 18:25:00 CST 2016, time=2016-05-06, status=1, ipAttribution=)]
    2016-09-26 howi
  4. [GetPortalCommentsPageByObjectIdResponse(id=106957, encodeId=a67610695ea7, content=深入学习,好文值得点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Aug 29 20:34:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104070, encodeId=bdeb1040e072, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Aug 26 06:46:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828470, encodeId=97be18284e06c, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Sep 26 23:04:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85209, encodeId=7ca18520945, content=以后还是少吃三文鱼为好, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Tue May 10 07:03:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84963, encodeId=379384963c5, content=三文鱼也是这样吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Mon May 09 11:13:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493415, encodeId=84f41493415b6, content=<a href='/topic/show?id=ebbbe7621c7' target=_blank style='color:#2F92EE;'>#线虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77621, encryptionId=ebbbe7621c7, topicName=线虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=133b9055992, createdName=zblhy, createdTime=Sun May 08 08:04:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84439, encodeId=a12684439ac, content=首次听说, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Fri May 06 18:25:00 CST 2016, time=2016-05-06, status=1, ipAttribution=)]
    2016-05-10 吴教授

    以后还是少吃三文鱼为好

    0

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    2016-05-09 jaysppr

    三文鱼也是这样吧

    0

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    2016-05-08 zblhy
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    2016-05-06 lovejing

    首次听说

    0

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