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盘点：2018年1月Gastroenterology研究精选

2018-01-04 zhangfan MedSci原创

Gastroenterology
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2018年1月Gastroenterology研究精选



【1】封面文章--BRF1基因突变与家族型结直肠癌相关


近日研究人员对一个结肠癌高风险家族中的个体进行了全外显子序列分析以识别与遗传性CRC相关的变异。

该西班牙家族共3名结肠癌患者，分别于65，62以及40岁确诊，研究人员采集患者血样进行全外显子序列分析，同时对547例其他结肠癌患者样本进行基因研究。

3名患者存在38个基因以及42个罕见（种群等位基因频率低于1%）非同义基因变异体。研究发现编码RNA聚合酶III转录起始因子亚基的BRF1基因与肿瘤相关。在503个CRC患者中，发现了11个BRF 1罕见的种系变异，其比例显著高于对照组(34/4300)，其中7种变异可影响BRF1 mRNA剪接，蛋白质的稳定、表达以及功能。

【2】霍乱疫苗可降低结直肠癌患者死亡风险


早前研究人员发现，霍乱疫苗具有抗炎作用，可以作为免疫反应的调节器，能够减少结肠息肉在结直肠癌(CRC)小鼠模型中的发育。近日研究人员考察了确诊CRC人群中霍乱疫苗(杀死霍乱弧菌O1全细胞和重组霍乱毒素B亚单位)对患者死亡率的影响。

175名CRC患者参与研究，在癌症确诊后给予霍乱疫苗处方。与对照相比，接受霍乱疫苗的CRC患者癌症特异性死亡（HR 0.53）以及总死亡（HR 0.59）风险降低。霍乱疫苗接种死亡率的下降在很大程度上是能够观察到的，与患者年龄、诊断出的肿瘤阶段或性别无关。

【3】大锯齿状息肉对异时大锯齿状息肉和高危腺瘤风险的影响


目前锯齿状息肉（SPS）的临床指南所包含的病人预后纵向数据十分有限。近日研究人员利用新罕布什尔州结肠镜检查中心检测数据评估了锯齿状息肉的临床异时性病变风险。

共5433人参与本次研究，平均年龄61岁，男性占49.7%，平均进行了2次结肠镜检查，平均随访4.9年。研究采用多变量逻辑回归模型评价锯齿状息肉（SP，N = 1016），高危腺瘤（HRA，N = 817），低危腺瘤（N = 1418），无腺瘤（N = 3198）对随后结肠镜检查确证的HRA或超过1cm的大SPS（异时性病变）的影响。亚组分析中同时进行SPS大小和组织学评估。锯齿状息肉包括增生性息肉，无蒂锯齿状腺瘤/息肉（SSA / PS）和传统锯齿状腺瘤，统称为STSAS。

研究发现，高危腺瘤并发大锯齿状息肉(OR 5.61)、或并发STSAS(OR 16.04)以及单独的高危腺瘤(OR 3.86)均显著提高患者异时性病变风险。大锯齿状息肉(OR=14.34)或STSA(OR 9.70)显著提高异时锯齿状息肉风险。

【4】结直肠癌家族史人群肿瘤筛查策略研究


结直肠癌(CRC)家族史个体的肠道肿瘤风险随年龄的增大而降低。近日研究人员对结肠癌家族史人群肿瘤筛查的成本效益进行了研究。

结肠癌患者一级亲属(FDRs)参与研究，考察不同年龄段一级亲属的筛查策略。增量成本效益比低于$100000每质量调整寿命年认为是最具成本效益的方法。

对于1名结直肠癌家族史人群（占所有参与者的92%），40岁开始，每3年1次是最具成本效益的筛查方法。若无腺瘤发现，在45-55岁期间，筛查频率可为每5-7年一次。对于超过1名以上结直肠患者的亲属，筛查应提前并缩短间隔。

【5】转化生长因子-β信号通路对肝癌进展的影响研究


肝癌(HCC)的发展与转化生长因子-β(TGF-β)信号途径改变有关，但该途径中的相关因子发挥的作用研究尚不明确。

研究人员对总计488名HCC患者的基因数据进行转录组分析。在HepG2， SNU398以及SNU475细胞中表达突变型SPTBN1，测量 SMAD3磷酸化、核转位和转录活性。

38%的HCC样本存在至少1处与TGF-β信号通路相关体细胞突变，SPTBN1突变率为6%。HCC样本中存在大量的TGF-β信号激活以及失活转录组数据。TGF-β失活患者的生存期更短，TGF-β信号转导模式与DNA损伤修复和Sirtuin信号通路激活相关。SPTBN1敲除或D1089Y突变可增加DNA毒物敏感性降低生存率。

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    2018-04-09 jktdtl

    #Gastroenterol#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2064293, encodeId=d0c120642935b, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Apr 09 16:37:00 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711331, encodeId=74fe1e113310a, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Oct 14 07:37:00 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072031, encodeId=29cd20e203109, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Oct 08 21:37:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277066, encodeId=eb2b2e706600, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 10 06:47:33 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504364, encodeId=2e5d15043648c, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sat Jan 06 05:37:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275481, encodeId=a86e2e5481a4, content=非常好.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Thu Jan 04 21:07:23 CST 2018, time=2018-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275428, encodeId=67ab2e542824, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Thu Jan 04 16:12:02 CST 2018, time=2018-01-04, status=1, ipAttribution=)]
    2018-10-14 ms24272190615788285182

    #AST#

    0

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    2018-10-08 许安

    #GAS#

    0

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    2018-01-10 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2064293, encodeId=d0c120642935b, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Apr 09 16:37:00 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711331, encodeId=74fe1e113310a, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Oct 14 07:37:00 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072031, encodeId=29cd20e203109, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Oct 08 21:37:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277066, encodeId=eb2b2e706600, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 10 06:47:33 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504364, encodeId=2e5d15043648c, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sat Jan 06 05:37:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275481, encodeId=a86e2e5481a4, content=非常好.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Thu Jan 04 21:07:23 CST 2018, time=2018-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275428, encodeId=67ab2e542824, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Thu Jan 04 16:12:02 CST 2018, time=2018-01-04, status=1, ipAttribution=)]
    2018-01-06 chaojitidian

    #Gastroenterology#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2064293, encodeId=d0c120642935b, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Apr 09 16:37:00 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711331, encodeId=74fe1e113310a, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Oct 14 07:37:00 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072031, encodeId=29cd20e203109, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Oct 08 21:37:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277066, encodeId=eb2b2e706600, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 10 06:47:33 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504364, encodeId=2e5d15043648c, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sat Jan 06 05:37:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275481, encodeId=a86e2e5481a4, content=非常好.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Thu Jan 04 21:07:23 CST 2018, time=2018-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275428, encodeId=67ab2e542824, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Thu Jan 04 16:12:02 CST 2018, time=2018-01-04, status=1, ipAttribution=)]
    2018-01-04 cscdliu

    非常好.学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2064293, encodeId=d0c120642935b, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Apr 09 16:37:00 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711331, encodeId=74fe1e113310a, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Oct 14 07:37:00 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072031, encodeId=29cd20e203109, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Oct 08 21:37:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277066, encodeId=eb2b2e706600, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 10 06:47:33 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504364, encodeId=2e5d15043648c, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sat Jan 06 05:37:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275481, encodeId=a86e2e5481a4, content=非常好.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Thu Jan 04 21:07:23 CST 2018, time=2018-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275428, encodeId=67ab2e542824, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Thu Jan 04 16:12:02 CST 2018, time=2018-01-04, status=1, ipAttribution=)]
    2018-01-04 139****5926

    好好文章学习了

    0

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