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JAHA：颈动脉中层厚度评分、阳性冠状动脉钙化评分与冠心病之间的关系

2017-01-22 xing.T MedSci原创

颈动脉中层厚度冠心病
关注

颈动脉IMT评分是基于规范的数据，逐步加入到弗雷明汉危险因素和冠状动脉钙化评分来预测不同种族的人群首次发生的冠心病。

颈总动脉和颈内动脉中层厚度（IMT）与冠状动脉心脏疾病相关，并且随着年龄的增长而增厚。当将年龄、性别、人种/民族的IMT百分位数加入到弗雷明汉危险因素和冠状动脉钙化评分可以提高冠心病的预测时。近日，心血管疾病领域权威杂志JAHA上发表了一篇研究文章，研究人员旨在评估动脉粥样硬化的多民族研究(MESA研究)（一个由白人、中国人、黑人和西班牙裔人组成的多民族队列）。

研究人员获取了年龄在45-84岁参与者的IMT数据。研究人员计算了MESA研究每一名参与者颈总动脉和颈内动脉IMT、性别和人种/民族特定的规范值以及组合成IMT评分。研究人员采用多变量Cox‐比例风险模型和Logistic回归模型来评估冠心病的预后，并将IMT评分加入到（1）性别、人种/民族和弗雷明汉危险因素的基础模型，（2）冠状动脉钙化的基础模型。研究人员估计了Harrell’s C统计量和曲线下面积。

研究人员对429例首次发生冠心病的患者进行了中位随访时间为10.2年（四分位距为9.7-10.7年）的随访。这些患者的平均年龄为62.1岁，参与者52.6%为女性。IMT评分使基础的曲线下面积从0.7210增加到了0.7396（P=0.0008），并且将阳性冠状动脉钙化积分加入到该模型中，则从0.7627增加到0.7714（P=0.02）。

由此可见，颈动脉IMT评分是基于规范的数据，逐步加入到弗雷明汉危险因素和冠状动脉钙化评分来预测不同种族的人群首次发生的冠心病。

原始出处：

Joseph F. Polak,et al. Carotid Intima‐Media Thickness Score, Positive Coronary Artery Calcium Score, and Incident Coronary Heart Disease: The Multi‐Ethnic Study of Atherosclerosis. JAHA.2017. http://jaha.ahajournals.org/content/6/1/e004612


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    2017-10-17 mhzhuang@stu.e

    #颈动脉#

    0

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    2017-07-25 夏天与十三菇凉

    #冠状动脉钙#

    0

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    2017-09-07 1249897bm45(暂无昵称)

    #动脉钙化#

    0

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    2017-01-24 zhaohui6731

    #AHA#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1843439, encodeId=b95d18434396c, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Tue Oct 17 08:09:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973503, encodeId=de0619e350354, content=<a href='/topic/show?id=3e72309122a' target=_blank style='color:#2F92EE;'>#冠状动脉钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30912, encryptionId=3e72309122a, topicName=冠状动脉钙)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Tue Jul 25 16:09:00 CST 2017, time=2017-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663262, encodeId=abf21663262f7, content=<a href='/topic/show?id=4bae3334873' target=_blank style='color:#2F92EE;'>#动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33348, encryptionId=4bae3334873, topicName=动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d1d25597695, createdName=1249897bm45(暂无昵称), createdTime=Thu Sep 07 12:09:00 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267376, encodeId=f35d126e376da, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Jan 24 04:09:00 CST 2017, time=2017-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269185, encodeId=78be1269185b2, content=<a href='/topic/show?id=686830913f7' target=_blank style='color:#2F92EE;'>#冠状动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30913, encryptionId=686830913f7, topicName=冠状动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Tue Jan 24 04:09:00 CST 2017, time=2017-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511269, encodeId=2bdf1511269ab, content=<a href='/topic/show?id=d4ae3091531' target=_blank style='color:#2F92EE;'>#冠状动脉钙化评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30915, encryptionId=d4ae3091531, topicName=冠状动脉钙化评分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=117e10313650, createdName=ms622625817193301, createdTime=Tue Jan 24 04:09:00 CST 2017, time=2017-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172032, encodeId=c3751e203297, content=学习了，很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Jan 22 21:45:19 CST 2017, time=2017-01-22, status=1, ipAttribution=)]
    2017-01-24 shizhenshan

    #冠状动脉钙化#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1843439, encodeId=b95d18434396c, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Tue Oct 17 08:09:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973503, encodeId=de0619e350354, content=<a href='/topic/show?id=3e72309122a' target=_blank style='color:#2F92EE;'>#冠状动脉钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30912, encryptionId=3e72309122a, topicName=冠状动脉钙)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Tue Jul 25 16:09:00 CST 2017, time=2017-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663262, encodeId=abf21663262f7, content=<a href='/topic/show?id=4bae3334873' target=_blank style='color:#2F92EE;'>#动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33348, encryptionId=4bae3334873, topicName=动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d1d25597695, createdName=1249897bm45(暂无昵称), createdTime=Thu Sep 07 12:09:00 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267376, encodeId=f35d126e376da, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Jan 24 04:09:00 CST 2017, time=2017-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269185, encodeId=78be1269185b2, content=<a href='/topic/show?id=686830913f7' target=_blank style='color:#2F92EE;'>#冠状动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30913, encryptionId=686830913f7, topicName=冠状动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Tue Jan 24 04:09:00 CST 2017, time=2017-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511269, encodeId=2bdf1511269ab, content=<a href='/topic/show?id=d4ae3091531' target=_blank style='color:#2F92EE;'>#冠状动脉钙化评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30915, encryptionId=d4ae3091531, topicName=冠状动脉钙化评分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=117e10313650, createdName=ms622625817193301, createdTime=Tue Jan 24 04:09:00 CST 2017, time=2017-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172032, encodeId=c3751e203297, content=学习了，很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Jan 22 21:45:19 CST 2017, time=2017-01-22, status=1, ipAttribution=)]
    2017-01-24 ms622625817193301

    #冠状动脉钙化评分#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1843439, encodeId=b95d18434396c, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Tue Oct 17 08:09:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973503, encodeId=de0619e350354, content=<a href='/topic/show?id=3e72309122a' target=_blank style='color:#2F92EE;'>#冠状动脉钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30912, encryptionId=3e72309122a, topicName=冠状动脉钙)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Tue Jul 25 16:09:00 CST 2017, time=2017-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663262, encodeId=abf21663262f7, content=<a href='/topic/show?id=4bae3334873' target=_blank style='color:#2F92EE;'>#动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33348, encryptionId=4bae3334873, topicName=动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d1d25597695, createdName=1249897bm45(暂无昵称), createdTime=Thu Sep 07 12:09:00 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267376, encodeId=f35d126e376da, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Jan 24 04:09:00 CST 2017, time=2017-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269185, encodeId=78be1269185b2, content=<a href='/topic/show?id=686830913f7' target=_blank style='color:#2F92EE;'>#冠状动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30913, encryptionId=686830913f7, topicName=冠状动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Tue Jan 24 04:09:00 CST 2017, time=2017-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511269, encodeId=2bdf1511269ab, content=<a href='/topic/show?id=d4ae3091531' target=_blank style='color:#2F92EE;'>#冠状动脉钙化评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30915, encryptionId=d4ae3091531, topicName=冠状动脉钙化评分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=117e10313650, createdName=ms622625817193301, createdTime=Tue Jan 24 04:09:00 CST 2017, time=2017-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172032, encodeId=c3751e203297, content=学习了，很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Jan 22 21:45:19 CST 2017, time=2017-01-22, status=1, ipAttribution=)]
    2017-01-22 tanxingdoctor

    学习了，很不错

    0