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Colloids Surf B Biointerfaces：新型纳米支架可有效促进人脂肪组织来源的间充质干细胞的骨传导

2018-10-09 MedSci MedSci原创

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已知埃洛石纳米管（HNT）是纳米医学应用中的一种新兴材料。然而，仍然需要在再生医学应用中全面研究HNTs。为了增强人脂肪组织来源的间充质干细胞（hADMSCs）的成骨潜能，本研究合成了一种磷酸钙2-D装饰纳米薄片（CaP）修饰的新型多功能纳米支架壳聚糖（CTs）功能化超磁埃洛石纳米管（M-HNTs）（称为M-HNTs-CTs-CaP）。 通过FE-SEM，FE-SEM-EDS，FE-HR-T

已知埃洛石纳米管（HNT）是纳米医学应用中的一种新兴材料。然而，仍然需要在再生医学应用中全面研究HNTs。为了增强人脂肪组织来源的间充质干细胞（hADMSCs）的成骨潜能，本研究合成了一种磷酸钙2-D装饰纳米薄片（CaP）修饰的新型多功能纳米支架壳聚糖（CTs）功能化超磁埃洛石纳米管（M-HNTs）（称为M-HNTs-CTs-CaP）。

通过FE-SEM，FE-SEM-EDS，FE-HR-TEM，XPS，FT-IR和VSM分析表征逐步修饰的纳米支架。通过茜素红S染色、磷酸盐定量和免疫细胞化学证实hADMSCs成骨潜力。结果显示，与HNT，M-HNT，M-HNTs-CT相比，纳米支架;CaP，M-HNTs-CaP和M-HNTs-CTs-CaP可显著增强并且上调细胞的成骨潜能。在所研究的纳米支架中，M-HNTs-CTs-CaP表现出最高的成骨作用，这是由于M-HNTs-CTs表面的CaP分布较多，以及由Fe3O4，壳聚糖和CaP的协同骨传导作用。此外，免疫细胞化学分析和形态学观察显示M-HNTs-CTs-CaP的表面成骨细胞分化良好。

综上所述，该研究结果表明，M-HNTs-CTs-CaP具有促进hADMSCs强成骨的潜力，并且可能作为骨组织工程高度适用的新一代纳米支架。

原始出处：

Lee YJ, Lee SC, et al., Surface functionalization of halloysite nanotubes with supermagnetic iron oxide, chitosan and 2-D calcium-phosphate nanoflakes for synergistic osteoconduction enhancement of human adipose tissue-derived mesenchymal stem cells. Colloids Surf B Biointerfaces. 2018 Sep 20;173:18-26. doi: 10.1016/j.colsurfb.2018.09.045. 

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    2019-09-16 夏天与十三菇凉

    #FAC#

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    2019-05-06 sunylz

    #Bio#

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    2018-11-14 waiwai3030

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    2019-01-08 shanyongle

    #ACE#

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    2019-05-10 h.y200607_23674418

    #间充质干细#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1956727, encodeId=47791956e27f5, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=12, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Mon Sep 16 03:29:00 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918316, encodeId=b92d1918316cd, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon May 06 19:29:00 CST 2019, time=2019-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783337, encodeId=b9ef1e83337e7, content=<a href='/topic/show?id=f16a499652' target=_blank style='color:#2F92EE;'>#Coll#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4996, encryptionId=f16a499652, topicName=Coll)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Wed Nov 14 23:29:00 CST 2018, time=2018-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655902, encodeId=9520165590275, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Tue Jan 08 06:29:00 CST 2019, time=2019-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815388, encodeId=8616181538860, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Fri May 10 03:29:00 CST 2019, time=2019-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345775, encodeId=f1801345e7560, content=<a href='/topic/show?id=f8c5843e3c5' target=_blank style='color:#2F92EE;'>#脂肪组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84373, encryptionId=f8c5843e3c5, topicName=脂肪组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66962500501, createdName=yige2004, createdTime=Thu Oct 11 04:29:00 CST 2018, time=2018-10-11, status=1, ipAttribution=)]
    2018-10-11 yige2004

    #脂肪组织#

    0