CSMO 2014 :恶性实体肿瘤继发血小板增多症研究现状

2014-07-09 安徽省立医院附院肿瘤科 胡长路 医学论坛网

在7月4日的第八届中国肿瘤内科大会会上,安徽省立医院附院肿瘤科的胡长路教授介绍了恶性实体瘤继发血小板增多症的研究现状。血小板增多发生于多种恶性肿瘤中,血小板的增多程度与肿瘤分期、淋巴结浸润与否存在一定的相关性。血小板增多会导致血液高凝状态,与血栓发生具有一定关系,并在肿瘤的疾病进展、转移方面都起着重要的作用,恶性实体肿瘤中血小板增多被认为是一个独立的预后因素。应用抑制血小板药物可能为肿瘤治疗的新观

在7月4日的第八届中国肿瘤内科大会会上,安徽省立医院附院肿瘤科的胡长路教授介绍了恶性实体瘤继发血小板增多症的研究现状。血小板增多发生于多种恶性肿瘤中,血小板的增多程度与肿瘤分期、淋巴结浸润与否存在一定的相关性。血小板增多会导致血液高凝状态,与血栓发生具有一定关系,并在肿瘤的疾病进展、转移方面都起着重要的作用,恶性实体肿瘤中血小板增多被认为是一个独立的预后因素。应用抑制血小板药物可能为肿瘤治疗的新观念。

血小板是血液中的重要成分之一,由骨髓造血组织中的巨核细胞产生,成熟的巨核细胞膜表面形成许多凹陷,伸入胞质之中,相邻的凹陷细胞膜血小板在凹陷深部相互融合,使巨核细胞部分胞质与母体分开。最后这些被细胞膜包围的与巨核细胞胞质分离开的成分脱离巨核细胞,经过骨髓造血组织中的血窦进入血液循环成为血小板,正常的血液中血小板数量较为恒定。血小板增多,是指循环血液里的血小板数异常增多,可发生于多种生理刺激;也可发生于感染、炎性疾病、药物作用之后和恶性肿瘤及一些慢性髓性疾病等情况。自1872年Riess首次报道了恶性肿瘤患者中存在血小板增多以来,恶性肿瘤与血小板增多的关系一直受到人们的重视。近年来,研究恶性肿瘤与血小板增多关系的文章时有报道。

血小板增多发生于多种恶性肿瘤中,血小板的增多程度与肿瘤分期、淋巴结浸润与否存在一定的相关性。在恶性肿瘤中血小板增多的机制目前尚未被完全阐明,但其对恶性肿瘤患者产生多种影响,如引起凝血异常、增加肿瘤血行转移的机会、对肿瘤患者的生存有着不利的影响。由于血小板计数是一种价廉,快速,方便的实验室检测手段,可以作为额外的恶性肿瘤标记物来预测肿瘤的预后。因此,抑制血小板药物有可能成为一类有发展潜力的抑制肿瘤转移的药物。

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    2015-03-30 liuhuangbo
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    2015-06-14 feifers
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