Ann Pharmacother:心血管合并症影响COPD患者支气管扩张剂的处方使用吗?

2017-10-26 王淳 环球医学

2017年10月,发表在《Ann Pharmacother》的一项由加拿大和美国科学家进行的横断面研究,考察了心血管合并症是否影响慢性阻塞性肺病(COPD)患者支气管扩张剂的处方。

2017年10月,发表在《Ann Pharmacother》的一项由加拿大和美国科学家进行的横断面研究,考察了心血管合并症是否影响慢性阻塞性肺病(COPD)患者支气管扩张剂的处方。

背景:血管疾病(CVD)是COPD患病率最高的合并症。支气管扩张剂因潜在不良的心血管事件需要在COPD-CVD人群中谨慎使用,然而,该高风险患者群体中,支气管扩张剂的处方现状知之甚少。

目的:旨在确定合并CVD是否与COPD患者支气管扩张剂处方的减少相关。此外,研究人员探讨了这种关系如何随着性别、合并哮喘和联合β受体阻滞剂(BB)的使用而受到影响。

方法:研究人员使用2010全国非卧床病人医疗护理调查进行了一项横断面研究。研究人员对所有≥40岁的确诊为COPD的患者就诊进行了研究。对调查加权数据进行的逻辑回归用于预测支气管扩张剂的治疗,确定性别、哮喘、BB对支气管扩张剂处方的影响。

结果:11627061个非卧床COPD就诊中,研究人员发现,合并CVD的COPD患者(32.3%)比未合并的患者(57.6%)使用支气管扩张剂治疗率显着性低。该影响受到性别、哮喘和BB所影响。女性比男性、BB不使用者比使用者、合并哮喘比不合并哮喘,处方降低更多。无论在服用BB的哮喘还是非哮喘的男性中,CVD都不影响支气管扩张剂的处方。

结论:除了也服用BB的男性外,多数合并CVD的COPD患者都很少可能服用支气管扩张剂。因此,本研究突出了指南很少可能观察到的具体患者亚组。

原始出处:

Adesanoye DT and Willey CJ. Does Cardiovascular Comorbidity Influence the Prescribing of Bronchodilators in Chronic Obstructive Pulmonary Disease? Ann Pharmacother. 2017 Oct;51(10):855-861. doi: 10.1177/1060028017712531.

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    2018-04-13 871538379

    CVD患者需注意避免使用LABA

    0

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    2018-07-16 yb6560
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    2018-01-08 jj000001
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