虚拟肿瘤帮助实现肿瘤治疗个体化

2015-12-08 QQduhq 译 MedSci原创

计算机模拟或“虚拟肿瘤”是爱荷华大学牙科学院的研究人员和Cellworks Group公司合作研发的新型创意。他们在在第57届美国血液学会年会暨博览会上正式提出。

计算机模拟或“虚拟肿瘤”是爱荷华大学牙科学院的研究人员和Cellworks Group公司合作研发的新型创意。他们在第57届美国血液学会年会暨博览会上正式提出。 


牙科教授Kim Alan Brogden认为,在虚拟肿瘤的帮助下,他们可测试某种药物治疗被肿瘤细胞抑制的免疫系统功能。因此,未来他们可能可以明确分类哪些药物适用于哪种类型肿瘤的患者,实现个体化治疗。

许多癌症通过重置“免疫检查点”或抑制免疫应答可以躲避患者免疫系统的攻击。 

免疫系统治疗药物通常用于修复免疫检查点以起到癌症治疗的效果。它们的主要成分为抗体,释放入机体后攻击癌细胞。 

然而,Brogden教授认为,不到20.5%的肿瘤患者应用这些药物有明显效果。研究人员认为,他们可以通过从患者的肿瘤细胞中提取出特异性基因信息以增加药物的有效性。

他们首先从患者肿瘤细胞中提取出特异性遗传信息,将其添加入特定药物中,并预测药物修复机体某些免疫检查点的效果。 

然后他们从机体中提取正常的肿瘤细胞并在实验室培养(具有相同的基因组成),以探究药物是否会产生相同的效果。 

如果实验效果与预期相符,则研究人员或可对病人采取个性化的肿瘤治疗方案。反之则需要进一步调整机体肿瘤细胞使之易于被肿瘤药物消灭。

Brogden教授的目标是研发探索出一个特定的治疗流程,以便有助于早期癌症诊断后帮助患者采取有效的、个性化的癌症治疗方法。不仅如此,研究人员还需分析这种个性化的癌症治疗方案所需的治疗时间、经济消费及对病人预后及生存率等多方面的影响。

原始出处:
University of Iowa news release, accessed 6 December 2015 via EurekAlert.

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    2015-12-27 hixiaoluo

    好文章,值得收藏

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    2015-12-10 jetleo

    牙科教授很牛

    0

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