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口腔菌群生态平衡变化背后的机制

2017-07-22 MedSci MedSci原创

菌群生态平衡牙周炎
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了解导致口腔菌群生态平衡变化背后的原因是未来牙周炎管理和治疗的必要条件。在口腔生态系统中，调节细菌生长的竞争手段是未知的，本研究旨在探讨组间功能性成分的关联，以及个别物质对口腔微生物的影响。采用表型微阵列高通量技术对15种口腔细菌的细胞表型进行分析。使用多变量统计分析检测呼吸活动诱因和，并评估类似的代谢活动。结果，碳和氮与健康相关细菌的呼吸有关，可以解释生物膜生长时的竞争相互作用。碳、氮、和肽似乎

了解导致口腔菌群生态平衡变化背后的原因是未来牙周炎管理和治疗的必要条件。在口腔生态系统中，调节细菌生长的竞争手段是未知的，本研究旨在探讨组间功能性成分的关联，以及个别物质对口腔微生物的影响。

采用表型微阵列高通量技术对15种口腔细菌的细胞表型进行分析。使用多变量统计分析检测呼吸活动诱因和，并评估类似的代谢活动。

结果，碳和氮与健康相关细菌的呼吸有关，可以解释生物膜生长时的竞争相互作用。碳、氮、和肽似乎可降低所有细菌的呼吸活性，但不显著。在24和48小时，所有化合物均未显著提高病理生物的活性。此外，病理生物的的代谢物需求是不同的，这表明他们的呼吸活动的集体调制具有难度。流式细胞仪检测表明，Biolog板中检测的代谢活性可能不是细菌细胞数的直接结果。此外，细胞膜的损伤可能不会影响整个呼吸活动。

总之，该方法证实了先前报道的细菌组间的竞争和协同相互作用，它们可以作为健康状况的标记或作为调节口腔环境的目标。

原始出处：

Emma Hernandez-Sanabria, Vera Slomka, et al., In vitro Increased Respiratory Activity of Selected Oral Bacteria May Explain Competitive and Collaborative Interactions in the Oral Microbiome. Front Cell Infect Microbiol. 2017; 7: 235. Published online 2017 Jun 7. doi: 10.3389/fcimb.2017.00235.

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    2017-07-23 lyh994

    这是系列研究中的一个部分吗？

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=225371, encodeId=7fe02253e10c, content=这是系列研究中的一个部分吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sun Jul 23 10:02:34 CST 2017, time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225145, encodeId=44a3225145c8, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Jul 22 19:16:57 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225140, encodeId=3b8c22514070, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Sat Jul 22 19:09:23 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225130, encodeId=aca22251308f, content=学习了解了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Sat Jul 22 18:40:47 CST 2017, time=2017-07-22, status=1, ipAttribution=)]
    2017-07-22 131****1460

    学习了受益匪浅。

    0

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    2017-07-22 王秀

    学习了，涨知识了！

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=225371, encodeId=7fe02253e10c, content=这是系列研究中的一个部分吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sun Jul 23 10:02:34 CST 2017, time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225145, encodeId=44a3225145c8, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Jul 22 19:16:57 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225140, encodeId=3b8c22514070, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Sat Jul 22 19:09:23 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225130, encodeId=aca22251308f, content=学习了解了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Sat Jul 22 18:40:47 CST 2017, time=2017-07-22, status=1, ipAttribution=)]
    2017-07-22 林3301

    学习了解了，谢谢分享

    0