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JAMA：胰岛β细胞再生新方法

2014-04-15 佚名 丁香园

胰岛β细胞胰岛素
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加利福尼亚大学研究人员的一项研究显示，新研发的阶梯式过程能将小鼠皮肤细胞转化为分泌胰岛素的β细胞。Hampton博士对此进行了报道，文章发表在2014年4月2日的The Journal of American Medical Association上。【原文下载】当研究人员采用独特的分子和重组因子混合物处理成纤维细胞时，这些细胞转化为内胚层样细胞。进一步用其它化合物处理，细胞转化为胰腺祖细胞样细胞

加利福尼亚大学研究人员的一项研究显示，新研发的阶梯式过程能将小鼠皮肤细胞转化为分泌胰岛素的β细胞。Hampton博士对此进行了报道，文章发表在2014年4月2日的The Journal of American Medical Association上。【原文下载】

当研究人员采用独特的分子和重组因子混合物处理成纤维细胞时，这些细胞转化为内胚层样细胞。进一步用其它化合物处理，细胞转化为胰腺祖细胞样细胞（PPLCs），进而可被诱导为成熟的胰岛素分泌细胞。

将PPLCs移植到高血糖小鼠体内1周后，动物血糖水平逐渐降低。移植8周以后，PPLCs产生具有完全功能性的胰岛β细胞。

由于胰岛β细胞再生能力有限，难以大量生成。这一最新的过程使细胞生命周期延长。除了增加被1型糖尿病破坏的胰岛素分泌细胞，该研究成果使人们对导致疾病的β细胞先天性缺陷有了进一步的认识。

原始出处：

Tracy Hampton，New Method for Generating Insulin-Secreting Beta Cells.JAMA. 2014;311(13):1282. doi:10.1001/jama.2014.3429.【原文下载】

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    2015-02-24 kord1982

    #新方法#

    0

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    2014-06-09 baoya

    #胰岛#

    0

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    2014-09-19 一闲

    #胰岛β细胞#

    0

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    2014-04-17 ms24272190615788285182

    #β细胞#

    0

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